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Prostate Cell News
Prostate Cell News is an online resource summarizing the latest prostate cell research.
Unlocking Ferroptosis in Prostate Cancer — the Road to Novel Therapies and Imaging Markers
[Nature Reviews Urology] The authors describe novel molecular underpinnings and metabolic drivers of ferroptosis, analyze the functions and mechanisms of ferroptosis in tumors, and highlight prostate cancer-specific susceptibilities to ferroptosis.
Blocking Lipid Synthesis Induces DNA Damage in Prostate Cancer and Increases Cell Death Caused by PARP Inhibition
[Science Signaling] Researchers found that combining a fatty acid synthase (FASN)i with the poly-ADP ribose polymerase (PARP) inhibitor olaparib, which induced cell death by blocking DNA damage repair, resulted in a more pronounced reduction in cell growth than that caused by either drug alone.
An Orthotopic Prostate Cancer Model for New Treatment Development Using Syngeneic or Patient-Derived Tumors
[The Prostate] Scientists described a novel micro-surgical technique for orthotopically implanting intact tumors pieces from cell line derived or patient derived tumors in the mouse prostate gland and monitoring tumor growth using magnetic resonance imaging.
An Integrated ceRNA Network Identifies miR-375 as an Upregulated miRNA Playing a Tumor Suppressive Role in Aggressive Prostate Cancer
[Oncogene] Researchers utilized stringent in silico methods to construct a large ceRNA network across different prostate cancer stages, and provided experimental demonstration for the competing regulation among protumorigenic SEC23A, PHTF2, and their corresponding ceRNA pairs.
Stem Cell Dynamics and Cellular Heterogeneity across Lineage Subtypes of Castrate Resistant Prostate Cancer
[Stem Cells] To gain biological insight and to identify potential treatment targets within heterogeneous tumor cell populations, researchers assessed the lineage hierarchy and molecular characteristics of various CRPC tumor subpopulations.
The Impact of Telomere Length on Prostate Cancer Aggressiveness, Genomic Instability, and Health Disparities
[Scientific Reports] Patient- and technically-matched tumour-blood whole genome sequencing data for 179 ancestrally defined treatment naïve prostate cancer patients which scientists assessed for telomere length in blood and tumor associations.
Enhancing the Anticancer Effect of Androgen Deprivation Therapy by Monocarboxylate Transporter 1 Inhibitor in Prostate Cancer Cells
[The Prostate] PCa cells (LNCaP and C4-2 cell line), which has high prostate-specific membrane antigen (PSMA) and androgen receptor (AR) expression among PCa cell lines, were used in this study.
Prostate Cancer and Liquid Biopsies: Clinical Applications and Challenges
[International Journal of Urology] Investigators provide a comprehensive overview of current clinical opportunities in managing prostate cancer through blood-based liquid biopsy, highlighting the progress made, and acknowledging the challenges that remain.
Targeting the Tumor Microenvironment, a New Therapeutic Approach for Prostate Cancer
[Prostate Cancer and Prostatic Diseases] The authors delineate the mechanisms by which tumor-associated macrophages, cancer-associated fibroblasts, and myeloid-derived suppressor cells interact with prostate cancer cells in the tumor microenvironment.
Convergent Therapeutics Announces FDA Clearance of IND Application for CONV01-α, a Best-in-Class Radioantibody Targeting Prostate-Specific Membrane Antigen
[Convergent Therapeutics Inc. (PR Newswire)] Convergent Therapeutics Inc. announced that the US FDA has cleared the investigational new drug (IND) application for CONV01-α, its lead candidate for the treatment of patients with advanced prostate cancer.
Clinically-Observed FOXA1 Mutations Upregulate SEMA3C through Transcriptional Derepression in Prostate Cancer
[Scientific Reports] Researchers characterized FOXA1 alterations with respect to its regulation of semaphorin 3C (SEMA3C). They revealed that FOXA1 alterations led to elevated levels of SEMA3C both in prostate cancer specimens and in vitro.
NCAPD3 Exerts Tumor-Promoting Effects in Prostatic Cancer via Dual Impact on miR-30a-5p by STAT3-MALAT1 and MYC
[Cell Death Discovery] Scientists confirmed that lncRNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) was induced by non-SMC condensin II complex subunit D3 (NCAPD3)-STAT3, and the expression of miR-30a-5p was controlled by NCAPD3 in prostate cancer cells by miRNA-seq.
Published since 2010, Prostate Cell News compiles top scientific journal articles covering the characterization, behavior, and culturing of prostate cells. Additionally, our editorial team curates the latest press releases, technical advances, jobs, and events relevant to the prostate cell research community. Prostate Cell News saves scientists valuable time while keeping them informed in their field, facilitating the rapid exchange of cutting edge research updates and science news.
