Study Shows Deadly Prostate Cancer Cells Have Stem Cell Qualities
Scientists showed that the cells responsible for generating deadly prostate cancer share some genetic qualities with the tissue-specific stem cells that naturally reside in the healthy prostate. [Press release from University of California, Los Angeles discussing online prepublication in Proceedings of the National Academy of Sciences] Press Release
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Targeting Cancer Stem Cell in Castration Resistant Prostate Cancer
The authors demonstrated that immortalized normal human prostate epithelial cells, which appeared non-tumorigenic in vivo, become tumorigenic and acquire stem cell phenotype after knocking down a tumor suppressor gene. [Clin Cancer Res] Abstract
Glucocorticoid Receptor Antagonism Reverts Docetaxel-Resistance in Human Prostate Cancer
The authors studied the role of the glucocorticoid receptor (GR) in docetaxel-resistant prostate cancer in order to improve current prostate cancer therapies. GR expression was analyzed in a tissue microarray of primary prostate cancer specimens from chemo-naïve and docetaxel-treated patients, and in cultured prostate cancer cell lines with acquired docetaxel-resistance. [Endocr Relat Cancer] Abstract
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