Molecular Breakthrough Could Halt the Spread of Prostate Cancer
Researchers show that a specific compound can inhibit the activity of a molecule which is key to how tumors form new blood vessels. The vessels are essential for the cancer cells to survive and multiply. The findings show that targeting a molecule called SRPK1 could stop progression of prostate cancer. [Press release from the University of Bristol discussing online prepublication in Oncogene] Press Release|Abstract
SYK Is a Candidate Kinase Target for the Treatment of Advanced Prostate Cancer
Scientists report the identification of the spleen kinase SYK as a mediator of metastatic dissemination in zebrafish and mouse xenograft models of human prostate cancer. While SYK has not been implicated previously in this disease, they found that its expression is upregulated in human prostate cancers and associated with malignant progression. [Cancer Res] Abstract
Evidence of Histidine and Aspartic Acid Phosphorylation in Human Prostate Cancer Cells
Scientists developed a method to identify previously undetected histidine and aspartic acid phosphorylations in a human prostate cancer progression model. A phosphoproteome of a cell line model is presented, with correlation of modified protein expression between the three states of cancer: non-tumorigenic, tumorigenic, and metastatic cells. [Naunyn Schmiedebergs Arch Pharmacol] Abstract
Can Urinary PCA3 Supplement PSA in the Early Detection of Prostate Cancer?
To improve early-detection biopsy decisions, scientists conducted a prospective validation trial to assess the diagnostic performance of the prostate cancer antigen 3 (PCA3) urinary assay for the detection of prostate cancer among men screened with prostate-specific antigen (PSA). [J Clin Oncol] Abstract
Genomic Rearrangements in Prostate Cancer
The authors review recent literature regarding the importance of genomic rearrangements in the pathogenesis of prostate cancer and the potential impact on patient care. [Curr Opin Urol] Abstract
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