Prostate Cell News

Prostate Cell News is an online resource summarizing the latest prostate cell research.

The Effect of Baseline O2 Conditions on the Response of Prostate Cancer Cells to Hypoxia

April 24, 2024

[American Journal Of Physiology-Cell Physiology] To determine how the baseline O2 level affected the subsequent response to hypoxia, scientists cultured PC-3 prostate cancer cells in either 18% or 5% O2 for two weeks prior to exposing them to hypoxia for 12-48 hours.

Zeb1-Controlled Metabolic Plasticity Enables Remodelling of Chromatin Accessibility in the Development of Neuroendocrine Prostate Cancer

April 24, 2024

[Cell Death & Differentiation] Multiomics analyses showed that prostate cancer cells underwent an intermediate state marked by Zeb1 expression with epithelial-mesenchymal transition, stemness, and neuroendocrine features during the development of neuroendocrine prostate cancer.

The Role of Extracellular Vesicles in the Treatment of Prostate Cancer

April 22, 2024

[Small] The authors discuss the recent advancements in the application of extracellular vesicle (EV) therapies and highlight EV-based functional materials as novel interventions for prostate cancer.

PARP-ish: Gaps in Molecular Understanding and Clinical Trials Targeting PARP Exacerbate Racial Disparities in Prostate Cancer

April 19, 2024

[Cancer Research] Investigators explore PARP nuclear functions, inhibition, and clinical relevance through the lens of racial differences.

ELK3 Destabilization by Speckle-Type Poz Protein Suppresses Prostate Cancer Progression and Docetaxel Resistance

April 18, 2024

[Cell Death & Disease] Researchers found that speckle-type POZ protein (SPOP)n and ELK3 were an interacting partner. The interaction between SPOP and ELK3 resulted in increased ELK3 ubiquitination and destruction, assisted by checkpoint kinase-mediated ELK3 phosphorylation.

Phospholipase PLA2G7 Is Complementary to GPX4 in Mitigating Punicic Acid Induced Ferroptosis in Prostate Cancer Cells

April 18, 2024

[iScience] The authors investigated the mechanisms underlying the toxicity of punicic acid, an isomer of conjugated linolenic acids bearing three conjugated double bonds highly prone to peroxidation, on prostate cancer cells.

FOXA1 Regulates Ribosomal RNA Transcription in Prostate Cancer

April 18, 2024

[The Prostate] Nucleolar proteomics data and large-scale immunofluorescence were re-analyzed to jointly identify the proteins localized at nucleolus. RNA-Seq data of five prostate cancer (PCa) cohorts were combined and integrated with multi-dimensional data to define the upregulated nucleolar transcription factors in PCa tissues.

A New Hope for Men with Metastatic Prostate Cancer

April 18, 2024

[McGill University Health Centre] The Research Institute of McGill University Health Centre has enrolled the first patients to take part in an early-stage, multi-centre clinical trial of Actinium-225, a radioactive isotope used as a treatment for metastatic prostate cancer.

Uq Researcher Dr Kevin Koo Awarded Prostate Cancer Foundation of Australia Research Grant

April 18, 2024

[The University of Queensland] Dr Kevin Koo, from The University of Queensland’s (UQ) Centre for Clinical Research, has been awarded one of five new research grants worth a combined value of $1.2 million from the Prostate Cancer Foundation of Australia.

Tumor Promoting Effect of Spheroids in an Orthotopic Prostate Cancer Mouse Model

April 17, 2024

[Scientific Reports] Investigators established a technique for intraprostatic implantation of prostate cancer (PCa) spheroids and to identify the impact of three-dimensional organization of PCa cells on tumor progression and metastasis in a representative in vivo model.

Unlocking Ferroptosis in Prostate Cancer — the Road to Novel Therapies and Imaging Markers

April 16, 2024

[Nature Reviews Urology] The authors describe novel molecular underpinnings and metabolic drivers of ferroptosis, analyze the functions and mechanisms of ferroptosis in tumors, and highlight prostate cancer-specific susceptibilities to ferroptosis.

Blocking Lipid Synthesis Induces DNA Damage in Prostate Cancer and Increases Cell Death Caused by PARP Inhibition

April 15, 2024

[Science Signaling] Researchers found that combining a fatty acid synthase (FASN)i with the poly-ADP ribose polymerase (PARP) inhibitor olaparib, which induced cell death by blocking DNA damage repair, resulted in a more pronounced reduction in cell growth than that caused by either drug alone.

Published since 2010, Prostate Cell News compiles top scientific journal articles covering the characterization, behavior, and culturing of prostate cells. Additionally, our editorial team curates the latest press releases, technical advances, jobs, and events relevant to the prostate cell research community. Prostate Cell News saves scientists valuable time while keeping them informed in their field, facilitating the rapid exchange of cutting edge research updates and science news.