YAP1 and AR Interactions Contribute to the Switch from Androgen-Dependent to Castration-Resistant Growth in Prostate Cancer
Scientists identified yes-associated protein 1 (YAP1), as a physiological binding partner and positive regulator of androgen receptor (AR) in prostate cancer. YAP1 and AR co-localize and interact with each other predominantly within cell nuclei by an androgen-dependent mechanism in a hormone naive and an androgen-independent mechanism in castration-resistant prostate cancer cells. [Nat Commun] Abstract
Cyanidin Induces Apoptosis and Differentiation in Prostate Cancer Cells
Researchers delineated the anti-proliferative activity and the cytodifferentiation properties mediated by cyanidin-3-O-β-glucopyranoside (C3G) treatment in the DU145 and LnCap human prostatic cancer cell lines. C3G produced anti-proliferative effects through activation of caspase-3 and induction of p21 protein expression. [Int J Oncol] Abstract
Cardiolipin Composition Correlates with Prostate Cancer Cell Proliferation
Investigators analyzed the interrelationship between cardiolipin (CL) composition and the proliferation of prostate cells by exposing PC-3 tumor cells to different fatty acids and by analyzing the CL composition in prostate tissue from prostate cancer patients after prostatectomy. [Mol Cell Biochem] Abstract
The Many Ways to Make a Luminal Cell and a Prostate Cancer Cell
Given that there are multiple cells that can regenerate prostatic tissue and give rise to prostate cancer, the focus should shift to defining the signaling mechanisms that drive differentiation and progenitor self-renewal. The authors review the literature, present the evidence and raise important unanswered questions that will help guide the field forward to dissecting critical mechanisms regulating stem cell differentiation and tumor-initiation. [Endocr Relat Cancer]
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Exploring the Use of Aspirin and a Diabetes Drug for Prostate Cancer Prevention and Control
Rutgers Cancer Institute of New Jersey population science researcher XiangLin Tan, MD, PhD, has been awarded an $852,705 Career Development Award from the National Cancer Institute to explore the use of aspirin and a diabetes drug for prostate cancer prevention and control, especially in obese men. [Rutgers Cancer Institute of New Jersey] Press Release
NCI-Designated Cancer Centers Expand, Four Awarded Comprehensive Designation
With the addition of the Tisch Cancer Institute at the Icahn School of Medicine at Mount Sinai in New York City, National Cancer Institute’s (NCI)’s cancer centers program now has 69 cancer centers in 35 states. The upgraded designations for the four centers that were already part of the NCI program—from standard cancer centers to comprehensive cancer centers—brings the total number of comprehensive cancer centers to 45. [National Cancer Institute]
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