The Many Ways to Make a Luminal Cell and a Prostate Cancer Cell|
Given that there are multiple cells that can regenerate prostatic tissue and give rise to prostate cancer, the focus should shift to defining the signaling mechanisms that drive differentiation and progenitor self-renewal. The authors review the literature, present the evidence and raise important unanswered questions that will help guide the field forward to dissecting critical mechanisms regulating stem cell differentiation and tumor-initiation. [Endocr Relat Cancer]
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