Prostate Cell News

Prostate Cell News is an online resource summarizing the latest prostate cell research.

Cyclin-Dependent Kinase 12 Deficiency Reprogrammes Cellular Metabolism to Alleviate Ferroptosis Potential and Promote the Progression of Castration-Resistant Prostate Cancer

May 15, 2024

[Clinical and Translational Medicine] Based on bioinformatics analysis, investigators evaluated the relationship between CDK12 deficiency and prostate cancer patient's prognosis and treatment resistance.

CYB561 Supports the Neuroendocrine Phenotype in Castration-Resistant Prostate Cancer

May 14, 2024

[PLOS One] Scientists hypothesized that neuroendocrine differentiated cells secreted neuropeptides that supported androgen-independent tumor growth and induced aggressiveness of adjacent proliferating tumor cells through a paracrine mechanism.

Dickkopf-1 (DKK1) Drives Growth and Metastases in Castration-Resistant Prostate Cancer

May 13, 2024

[Cancer Gene Therapy] The authors investigated the role of the Wnt signaling modulator Dickkopf-1 (DKK1) in the growth and metastatic progression of metastatic CRPC.

Cutibacterium acnes Invades Prostate Epithelial Cells to Induce BRCAness as a Possible Pathogen of Prostate Cancer

May 10, 2024

[The Prostate] To identify microbiota or pathogens associated with prostate cancer, researchers investigated the transcriptomes of 20 human prostate cancer tissues.

Novel Role of LLGL2 Silencing in Autophagy: Reversing Epithelial-Mesenchymal Transition in Prostate Cancer

May 10, 2024

[Biological Research] PC3 cells were transfected with siLLGL2 or plasmid LLGL2 and autophagy was examined. Invasion, migration, and wound healing were assessed in PC3 cells under autophagy regulation.

UBE2N Promotes Cell Viability and Glycolysis by Promoting Axin1 Ubiquitination in Prostate Cancer Cells

May 9, 2024

[Biology Direct] Ubiquitin-conjugating enzyme E2 N (UBE2N) expression was detected in Cancer Genome Atlas Prostate Adenocarcinoma data, prostate cancer tissue microarrays, and prostate cancer cell lines, respectively.

Sphingolipids in Prostate Cancer Prognosis: Integrating Single-Cell and Bulk Sequencing

May 9, 2024

[Aging] Single-cell sequencing data for prostate cancer were sourced from the pradcellatlas website, while bulk transcriptome data were obtained from the TCGA database.

Aberrant Activation of TGF-β/ROCK1 Enhances Stemness during Prostatic Stromal Hyperplasia

May 7, 2024

[Cell Communication and Signaling] Investigators demonstrated that the aberrant activation of transforming growth factor β (TGF-β)/Rho kinase 1 (ROCK1) increased the stemness of benign prostatic hyperplasia (BPH) tissue by recruiting mesenchymal stem cells, indicating the important role of embryonic reawakening in BPH.

Discovery and Pharmacological Characterization of 1,2, 3,4-Tetrahydroquinoline Derivatives as RORγ Inverse Agonists against Prostate Cancer

May 6, 2024

[Acta Pharmacologica Sinica] The authors reported the identification, optimization, and evaluation of 1,2,3,4-tetrahydroquinoline derivatives as novel RORγ inverse agonists, starting from high throughput screening using a thermal stability shift assay.

Differential Analysis of Histopathological and Genetic Markers of Cancer Aggressiveness, and Survival Difference in EBV-Positive and EBV-Negative Prostate Carcinoma

May 6, 2024

[Scientific Reports] Scientists used previously characterized Epstein-Barr virus (EBV)-PCR-positive and EBV-negative prostate carcinoma (PCa) tissues to perform an IHC-based assessment of key histopathological and molecular markers of PCa aggressiveness

Androgen Receptor Splice Variants Drive Castration-Resistant Prostate Cancer Metastasis by Activating Distinct Transcriptional Programs

May 3, 2024

[Journal Of Clinical Investigation] Investigators found that, under castrated conditions, androgen receptor (AR)-V7 strongly induced osteoblastic bone lesions, a response not observed with full-length AR overexpression.

Prostate Cancer Screening Methods Trialed in ‘Pivotal Moment’

May 3, 2024

[The Guardian] Methods of screening men for prostate cancer will be trialed in an attempt to save thousands of lives in the UK each year, in what has been hailed as a “pivotal moment” by experts.

Published since 2010, Prostate Cell News compiles top scientific journal articles covering the characterization, behavior, and culturing of prostate cells. Additionally, our editorial team curates the latest press releases, technical advances, jobs, and events relevant to the prostate cell research community. Prostate Cell News saves scientists valuable time while keeping them informed in their field, facilitating the rapid exchange of cutting edge research updates and science news.