Prostate Cell News

Prostate Cell News is an online resource summarizing the latest prostate cell research.

A Compound That Inhibits Glycolysis in Prostate Cancer Controls Growth of Advanced Prostate Cancer

[Molecular Cancer Therapeutics] Scientists reported the preclinical activity, safety, and pharmacokinetics of a novel small molecule preclinical candidate, BKIDC-1553, with antiglycolytic activity. A human PDX model implanted in mice and a human organoid was studied for sensitivity to our BKIDC preclinical candidate.

Acetylated KHSRP Impairs DNA-Damage-Response-Related mRNA Decay and Facilitates Prostate Cancer Tumorigenesis

[Molecular Oncology] The authors found that androgen could significantly induce acetylation of far upstream element-binding protein 2 (KHSRP), which intrinsically drove tumor growth in xenografted mice.

State-of-the-Art in Transposable Element Modulation Affected by Drugs in Malignant Prostatic Cancer Cells

[Journal of Cellular Biochemistry] The authors focus on prostate carcinoma cell lines and offer a comprehensive review intended to scrutinize the associations and interactions between transposable elements and genes.

The Prostate Cancer Foundation Announces 2023 Challenge Awards Totaling More Than $21 Million For Prostate Cancer Research

[The Prostate Cancer FoundationThe Prostate Cancer Foundation] The Prostate Cancer Foundation (PCF) today announced the 2023 Class of PCF Team Challenge Award recipients and a total of more than $21 million in funding for innovative prostate cancer research.

$1.25 Million Prostate Cancer Research Grant

[University of Alberta] Prostate cancer research team including Drs. Roseline Godbout, Adam Kinnaird, and Ron Moore have been awarded a $1.25 million, four-year Alberta Cancer Foundation “Game Changer Grant” to investigate the link between fat metabolism and prostate cancer progression.

Dual Deficiency of Melatonin and Dihydrotestosterone Promotes Stromal Cell Damage and Mediates Prostatitis via the cGAS-STING Pathway in Sleep-Deprived Mice

[Cell Communication and Signaling] Sleep deprivation (SD) was utilized to establish a mouse model of insufficient sleep in a special device. Prostatitis was observed at different time points post-SD.

CPT1A Mediates the Succinylation of SP5 Which Activates Transcription of PDPK1 to Promote the Viability and Glycolysis of Prostate Cancer Cells

[Cancer Biology & Therapy] The authors investigated the role of carnitine palmitoyltransferase 1A (CPT1A), which was a succinyltransferase in the progression of prostate cancer. CCK-8 was used to detect the cell viability.

TP63–TRIM29 Axis Regulates Enhancer Methylation and Chromosomal Instability in Prostate Cancer

[Epigenetics & Chromatin] Investigators integrated DNA methylation, RNA-seq, and copy number alterations datasets from The Cancer Genome Atlas, focusing on prostate adenocarcinoma, and employed weighted gene co-expression network analysis.

DHODH Inhibition Represents a Therapeutic Strategy and Improves Abiraterone Treatment in Castration-Resistant Prostate Cancer

[Oncogene] The authors showed that dihydroorotate dehydrogenase (DHODH), an enzyme crucial in the pyrimidine biosynthesis pathway, was a promising therapeutic target for CRPC. The transcript levels of DHODH were significantly elevated in prostate tumors.

Caffeic Acid Phenethyl Ester Suppresses the Expression of Androgen Receptor Variant 7 via Inhibition of CDK1 and AKT

[Oncogene] Scientists discovered that caffeic acid phenethyl ester could repress the expression and downstream signaling of AR-V7 in prostate cancer cells.

Dexamethasone Inhibits Androgen Receptor-Negative Prostate Cancer Cell Proliferation via the GR-FOXO3a-GAS5 Axis

[Heliyon] Glucocorticoid receptor (GR) expression and its prognosis role were analyzed based on the TCGA dataset. Bioinformatic analysis was performed to identify the candidate of GR downstream, which includes FOXO3a.

YTHDF2 Protein Stabilization by the Deubiquitinase OTUB1 Promotes Prostate Cancer Cell Proliferation via PRSS8 mRNA Degradation

[Journal of Biological Chemistry] With in vivo and in vitro ubiquitination assays, OUT domain-containing ubiquitin aldehyde-binding protein 1 (OTUB1) was shown to block ubiquitin transfer to YTH domain-containing family protein 2 (YTHDF2) independent of its deubiquitinase activity.

Published since 2010, Prostate Cell News compiles top scientific journal articles covering the characterization, behavior, and culturing of prostate cells. Additionally, our editorial team curates the latest press releases, technical advances, jobs, and events relevant to the prostate cell research community. Prostate Cell News saves scientists valuable time while keeping them informed in their field, facilitating the rapid exchange of cutting edge research updates and science news.

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