Volume 7.06 | Feb 19

Prostate Cell News 7.06 February 19, 2016
Prostate Cell News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Secretory Leukocyte Protease Inhibitor Is a Survival and Proliferation Factor for Castration-Resistant Prostate Cancer
Scientists provide the first evidence that secretory leukocyte peptidase inhibitor is upregulated in a subset of castration-resistant prostate cancer cell lines and castration-resistant prostate cancer patient tumors. [Oncogene] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
LABORATORY RESEARCH

Interaction of EGFR to Delta-Catenin Leads to Delta-Catenin Phosphorylation and Enhances EGFR Signaling
Scientists investigated the possible correlation between epidermal growth factor receptor (EGFR) and δ-catenin in prostate cancer cells. They found that EGFR interacted with δ-catenin and the interaction decreased in the presence of EGF. [Sci Rep] Full Article

Increased Expression of Fibroblast Growth Factor 13 (FGF13) in Prostate Cancer Is Associated with Shortened Time to Biochemical Recurrence after Radical Prostatectomy
Researchers examined the FGF13 expression pattern in human prostate cancer specimens and evaluated its potential as a biomarker for patient outcome after radical prostatectomy. [Int J Cancer] Abstract

UHRF1 Overexpression Is Involved in Cell Proliferation and Biochemical Recurrence in Prostate Cancer after Radical Prostatectomy
UHRF1 was overexpressed in almost all of the prostate cancer (PCa) cell lines. In PCa cells, UHRF1 knockdown inhibited cell proliferation and migration, and induced apoptosis. [J Exp Clin Cancer Res] Full Article

Diet-Induced Alteration of Fatty Acid Synthase in Prostate Cancer Progression
The authors investigated the role of fatty acid synthase on prostate cancer (PCa) progression in LNCaP xenograft mice fed with high-fat diet or low-fat diet, in PCa cells, and in clinical PCa. [Oncogenesis] Full Article

Relative Cytotoxic Potencies and Cell Death Mechanisms of α1-Adrenoceptor Antagonists in Prostate Cancer Cell Lines
PC-3 and LNCap human prostate cancer cells were exposed to α1-adrenoceptor antagonists and cell survival assessed after 24-72 hr. The levels of apoptosis, autophagy and stress related proteins were also determined. [Prostate] Abstract

Epidermal Growth Factor Induces P38 MAPK-Dependent G0/G1-to-S Transition in Prostate Cancer Cells upon Androgen Deprivation Conditions
Investigators showed that, in LNCaP cells, androgen deprivation induces arrest in the G0/G1 cell cycle phase, and that epidermal growth factor partially rescues this arrest without affecting cell death. [Growth Factors] Abstract

Tumor Growth Kinetics before and after First-Line Chemotherapy in Metastatic Castration-Resistant Prostate Cancer: A Prostate-Specific Antigen-Based Retrospective Analysis
The authors assessed whether some prostate-specific antigen-related variables of tumor cell kinetics predict the overall survival in early and late metastatic castration-resistant prostate cancer, and to explore changes in the tumor growth fraction after chemotherapy. [Am J Clin Oncol] Abstract

Interactive Effects of 9-cis-Retinoic Acid and Androgen on Proliferation, Differentiation, and Apoptosis of LNCaP Prostate Cancer Cells
LNCaP and PC-3 cells were cultured and treated with a range of 9-cis-retinoic acid (9cRA) concentrations for 3-6 days in the absence or presence of 5α-dehydrotestosterone. 9cRA inhibited cell proliferation in a dose-dependent manner, plateauing at 10 mol/l. [Eur J Cancer Prev] Abstract

CLINICAL RESEARCH

Abiraterone Acetate for Metastatic Castration-Resistant Prostate Cancer after Docetaxel Failure: A Randomized, Double-Blind, Placebo-Controlled Phase III Bridging Study
Scientists evaluated the efficacy and safety of abiraterone acetate-prednisone versus placebo-prednisone in Asian metastatic castration-resistant prostate cancer patients who have failed docetaxel-based chemotherapy. [Int J Urol] Abstract

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REVIEWS
Clonality of Localized and Metastatic Prostate Cancer
The influence of the long life-history of prostate cancer on the temporal and spatial variability of the tumor genome is now being elucidated. Multiregion sequencing to identify spatio-genomic differences in prostate tumor mutation profiles combined with computational approaches can map the evolution and transit of tumor cells throughout an individual patient. [Curr Opin Urol] Abstract

Visit our reviews page to see a complete list of reviews in the prostate cell research field.
 
INDUSTRY NEWS
Senior Scientific and Weill Cornell Medicine to Pursue Non-Invasive Prostate Cancer Detection
Manhattan Scientifics, Inc. announced that its wholly-owned subsidiary Senior Scientific, LLC has established a research collaboration with Weill Cornell Medicine. For the alliance, the company will bring its magnetic relaxometry technology to Weill Cornell Medicine, where scientists will investigate the use of molecularly targeted nanoparticles to non-invasively detect and diagnose prostate cancers. [Manhattan Scientifics, Inc.] Press Release

Novel Route to Serum Based Prostate Cancer Diagnostics
Protagen AG announced the identification of novel protein biomarkers in prostate cancer, which are potential drug targets supporting novel strategies in precision medicine. [Protagen AG] Press Release

Georgia Urology Partners with Vituro Health to Bring HIFU, Concierge Medicine Offerings to Atlanta
Georgia Urology, located in Atlanta, partnered with Vituro Health to give their patients close-to-home access to the latest treatment available just months after the FDA cleared high intensity focused ultrasound (HIFU) therapy in the U.S. [Vituro Health]  

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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW 12th International Conference of the Asian Clinical Oncology Society (ACOS)
April 8-10, 2016
New Delhi, India

Visit our events page to see a complete list of events in the prostate cell community.
 
JOB OPPORTUNITIES
NEW Postdoctoral Fellowship – Epidemiology of Prostate Cancer (Fred Hutchinson Cancer Research Center)

NEW Research Group Leader – Stress Regulated Processes During Oncogenesis (INSERM)

PhD Position – Experimental Radiotherapy in Prostate Cancer (Katholieke Universiteit Leuven)

Postdoctoral Fellowship – Cancer Epigenomics (Princess Margaret Cancer Centre)

Postdoctoral Fellowship – Prostate Cancer Biology (Medical University of South Carolina )

Postdoctoral Fellowship – Prostate Cancer and Cancer Metabolism (Cleveland Clinic)

Post-Doc Fellowship – Metastasis of Cancer (University of Arizona Cancer Center)

Post-Doc Fellowship – Molecular Imaging for Prostate Cancer (Case Western Reserve University)

Post-Doc Fellowship/Staff Scientist – Prostate Cancer Epidemiology (Memorial Sloan Kettering Cancer Center)

Faculty Position – Urology Research (Mayo Clinic)

Post-Doc Fellowship – Cancer Stem Cell Biology (Weill Cornell Medical College)

Postdoctoral Research Fellow – Cell Cycle Control and Tumorigenesis (Fred Hutchinson Cancer Research Center)

Division Head – Medical Oncology (Fred Hutchinson Cancer Research Center)


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