Volume 7.02 | Jan 22

Prostate Cell News 7.02 January 22, 2016
Prostate Cell News
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Organoid Culture Systems for Prostate Epithelial and Cancer Tissue
This protocol describes a strategy for the generation of 3D prostate organoid cultures from healthy mouse and human prostate cells (either bulk or FACS-sorted single luminal and basal cells), metastatic prostate cancer lesions and circulating tumor cells. [Nat Protoc] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)

The Role of Mesenchymal Stem Cells in Promoting the Transformation of Androgen-Dependent Human Prostate Cancer Cells into Androgen-Independent Manner
Researchers investigated the underlying mechanism of mesenchymal stem cells in promoting prostate cancer cells from androgen-dependent into androgen-independent manner. [Sci Rep] Full Article

Microbubble-Mediated Ultrasound Promotes Accumulation of Bone Marrow Mesenchymal Stem Cell to the Prostate for Treating Chronic Bacterial Prostatitis in Rats
A therapeutic-ultrasound apparatus was used to treat the prostate in the presence of circulating microbubbles and bone marrow mesenchymal stem cells (BMMSCs). The BMMSC distribution was assessed with in vivo imaging, and the prostate structure with light microscopy. [Sci Rep] Full Article

Signaling Network Controlling Androgenic Repression of c-Fos in Prostate Adenocarcinoma Cells
The authors showed that androgens suppress c-Fos protein and mRNA expression induced by 12-O-tetradecanoylphorbol-13-acetate or epidermal growth factor in human prostate cancer cell lines. [J Biol Chem] Abstract | Full Article

Texas Native Plants Yield Compounds with Cytotoxic Activities against Prostate Cancer Cells
Three Texas native plants yielded three new and three known compounds with antiproliferative and cytotoxic activities against prostate cancer cells with IC50 values in the range of 1.7-35.0 μM. [J Nat Prod] Abstract

AXIN2 Expression Predicts Prostate Cancer Recurrence and Regulates Invasion and Tumor Growth
Low AXIN2 expression was associated with prostate cancer (PCa) recurrence after radical prostatectomy in a test population as well as in external validation cohorts, and its expression levels in PCa cells significantly impacted invasiveness, proliferation, and tumor growth. [Prostate] Abstract

ΔNp63α Transcriptionally Regulates the Expression of CTEN that Is Associated with Prostate Cell Adhesion
The study demonstrated that ΔNp63 and C-terminal tensin-like (CTEN) are both highly expressed in normal prostate epithelial cells and are down-regulated in prostate cancer. In addition, reduced expression of CTEN and ΔNp63 was correlated with prostate cancer progression from primary tumors to metastatic lesions. [PLoS One] Full Article

A Novel High Content Imaging-Based Screen Identifies the Anti-Helminthic Niclosamide as an Inhibitor of Lysosome Anterograde Trafficking and Prostate Cancer Cell Invasion
Scientists designed a high-content assay to discover drugs that block peripheral lysosome trafficking with the goal of identifying novel drugs that inhibit tumor cell invasion. An automated high-content imaging system was used to measure the position of lysosomes relative to the nucleus. [PLoS One] Full Article


Association between Statins and Clinical Outcomes Among Men with Prostate Cancer: A Systematic Review and Meta-Analysis
A systematic review found that statin significantly reduced the all-cause and prostate cancer-specific mortality and improved the biochemical recurrence in certain subgroup of men with prostate cancer. [Prostate Cancer Prostatic Dis] Abstract

Greater Extent of Prostate Inflammation in Negative Biopsies Is Associated with Lower Risk of Prostate Cancer on Repeat Biopsy: Results from the REDUCE Study
In a cohort of men undergoing repeat prostate biopsy 2 years after a negative baseline biopsy, a greater extent of baseline acute prostate inflammation and chronic prostate inflammation was independently associated with lower prostate cancer risk. [Prostate Cancer Prostatic Dis] Abstract

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Lower Urinary Tract Symptoms, Benign Prostatic Hyperplasia and Metabolic Syndrome
Results from multiple preclinical and clinical studies indicate that several modifiable, age-related metabolic aberrations (metabolic syndrome, obesity, dyslipidaemia, diabetes) are important determinants in both the development and the progression of benign prostatic hyperplasia-related lower urinary tract symptoms (BPH–LUTS). Metabolic syndrome and its related comorbidities, such as sex steroid alterations and low-grade inflammation, have been related to BPH–LUTS development and progression. [Nat Rev Urol] Abstract

Visit our reviews page to see a complete list of reviews in the prostate cell research field.
Pathcore Selected by National Cancer Institute to Enable Cancer Informatics Development
Pathcore™ and a team of investigators from the US and Canada have received an award from the National Cancer Institute to develop a pathology informatics platform. This will allow researchers to develop automated cancer detection image analysis tools which can be easily distributed to research and clinical users. [Pathcore™ (Business Wire)] Press Release

Tiziana Life Sciences to Drive Its First-in-Class Bcl-3 Inhibitor, Focused on a Novel Cancer Target, into the Clinic in 2016
Tiziana Life Sciences PLC announced that its research agreement with Cardiff University, focused on pioneering the development of Bcl-3 inhibitors as potential drugs to treat cancer, has led to the identification of a first-in-class lead clinical candidate, CB1, with potent anti-metastatic activity, and with an impressive in vivo efficacy and safety profile. [Tiziana Life Sciences PLC] Press Release

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National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW The Stem Cell Niche 2016
May 22-26, 2016
Hillerod, Denmark

Visit our events page to see a complete list of events in the prostate cell community.
NEW Post-Doc Fellowship – Molecular Imaging for Prostate Cancer (Case Western Reserve University)

NEW Post-Doc Fellowship/Staff Scientist – Prostate Cancer Epidemiology (Memorial Sloan Kettering Cancer Center )

Postdoctoral Researcher – Prostate Cancer Biology (Roswell Park Cancer Institute)

Faculty Position – Urology Research (Mayo Clinic)

Faculty Position – Cancer Biology (Michigan State University)

Post-Doc Fellowship – Cancer Stem Cell Biology (Weill Cornell Medical College)

Postdoctoral Position – Bioinformatics (Princess Margaret Cancer Centre)

Professor Position – Cancer Immunotherapy (City of Hope)

Postdoctoral Research Fellow – Cell Cycle Control and Tumorigenesis (Fred Hutchinson Cancer Research Center)

Postdoctoral Positions – Prostate Cancer (Baylor College of Medicine)

Division Head – Medical Oncology (Fred Hutchinson Cancer Research Center)

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