Prostate Cell News

Prostate Cell News is an online resource summarizing the latest prostate cell research.

DHODH Inhibition Represents a Therapeutic Strategy and Improves Abiraterone Treatment in Castration-Resistant Prostate Cancer

[Oncogene] The authors showed that dihydroorotate dehydrogenase (DHODH), an enzyme crucial in the pyrimidine biosynthesis pathway, was a promising therapeutic target for CRPC. The transcript levels of DHODH were significantly elevated in prostate tumors.

Caffeic Acid Phenethyl Ester Suppresses the Expression of Androgen Receptor Variant 7 via Inhibition of CDK1 and AKT

[Oncogene] Scientists discovered that caffeic acid phenethyl ester could repress the expression and downstream signaling of AR-V7 in prostate cancer cells.

Dexamethasone Inhibits Androgen Receptor-Negative Prostate Cancer Cell Proliferation via the GR-FOXO3a-GAS5 Axis

[Heliyon] Glucocorticoid receptor (GR) expression and its prognosis role were analyzed based on the TCGA dataset. Bioinformatic analysis was performed to identify the candidate of GR downstream, which includes FOXO3a.

YTHDF2 Protein Stabilization by the Deubiquitinase OTUB1 Promotes Prostate Cancer Cell Proliferation via PRSS8 mRNA Degradation

[Journal of Biological Chemistry] With in vivo and in vitro ubiquitination assays, OUT domain-containing ubiquitin aldehyde-binding protein 1 (OTUB1) was shown to block ubiquitin transfer to YTH domain-containing family protein 2 (YTHDF2) independent of its deubiquitinase activity.

Adipose Triglyceride Lipase Is a Therapeutic Target in Advanced Prostate Cancer That Promotes Metabolic Plasticity

[Cancer Research] The authors identified that expression of adipose triglyceride lipase, an enzyme that controlled lipid droplet homeostasis and a previously suspected tumor suppressor, correlated with worse overall survival in men with advanced CRPC.

Single-Cell Sequencing Revealed Metabolic Reprogramming and Its Transcription Factor Regulatory Network in Prostate Cancer

[Translational Oncology] The authors utilized single-cell sequencing to comprehensively characterize the alterations in metabolism and the regulatory role of transcription factors in various subtypes of prostate cancer.

Researchers Awarded £2.6M to Develop Preclinical Lead Drug Candidate for Advanced Prostate and Colorectal Cancers

[University of Strathclyde] Researchers at the University of Strathclyde have been awarded £2.6 million to develop a preclinical lead drug candidate targeted at advanced prostate and colorectal cancers.

Transformational $50 Million Gift from Kenneth C. Griffin to Boost Sylvester’s Research Footprint

[News Medical Life Sciences] The University of Miami announced a transformational $50 million gift from Kenneth C. Griffin, Founder and Chief Executive Officer of Citadel and Founder of Griffin Catalyst, to Sylvester Comprehensive Cancer Center, part of the University of Miami Health System and the Miller School of Medicine.

Single-Cell RNA Combined with Bulk RNA Analysis to Explore Oxidative Stress and Energy Metabolism Factors and Found a New Prostatic Cancer Oncogene MXRA8

[Aging] Integrating single-cell RNA sequencing and bulk RNA-seq data, the authors identified two molecular subtypes of prostate cancer based on dysregulated genes involved in oxidative stress and energy metabolism.

Beyond the Genome: MALAT1’s Role in Advancing Urologic Cancer Care

[Pathology - Research and Practice] MALAT1 is a flexible tumor regulator implicated in an array of biological activities and disorders, resulting in an important research issue. MALAT1 appears as a hotspot, having been linked to the dysregulation of cell communication, and is intimately linked to cancer genesis, advancement, and response to treatment.

Transformational $50 Million Gift from Kenneth C. Griffin to Boost Sylvester’s Research Footprint

[News Medical Life Sciences] The University of Miami announced a transformational $50 million gift from Kenneth C. Griffin, Founder and Chief Executive Officer of Citadel and Founder of Griffin Catalyst, to Sylvester Comprehensive Cancer Center, part of the University of Miami Health System and the Miller School of Medicine.

Cancer Grand Challenges Selects Five New Global, Interdisciplinary Teams to Take On Four Challenges

[National Cancer Institute] Cancer Grand Challenges has selected five new global research teams that will address the following challenges in cancer: reducing cancer inequities, understanding the mechanisms of early-onset cancers, developing drugs for solid tumors in children, and broadening our knowledge about how T cells recognize cancer cells.

Published since 2010, Prostate Cell News compiles top scientific journal articles covering the characterization, behavior, and culturing of prostate cells. Additionally, our editorial team curates the latest press releases, technical advances, jobs, and events relevant to the prostate cell research community. Prostate Cell News saves scientists valuable time while keeping them informed in their field, facilitating the rapid exchange of cutting edge research updates and science news.

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