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Prostate Cell News is an online resource summarizing the latest prostate cell research.
The Gut Microbiome-Prostate Cancer Crosstalk Is Modulated by Dietary Polyunsaturated Long-Chain Fatty Acids
[Nature Communications] Scientists showed a reduction in fecal microbiota alpha-diversity correlating with increase tumor burden in two distinct groups of hormonotherapy naïve prostate cancer (PCa) patients and three murine PCa models.
High Clonal Diversity and Spatial Genetic Admixture in Early Prostate Cancer and Surrounding Normal Tissue
[Nature Communications] Scientists performed multi-region, single-cell DNA sequencing to characterize the somatic copy number alteration landscape across tumor-rich and normal tissue in two male patients with localized prostate cancer.
ACSM1 and ACSM3 Regulate Fatty Acid Metabolism to Support Prostate Cancer Growth and Constrain Ferroptosis
[Cancer Research] Researchers identified acyl-CoA synthetase medium chain family members 1 and 3 (ACSM1 and ACSM3) as androgen receptor-regulated mediators of prostate cancer metabolism and growth.
Kinesin Facilitates Phenotypic Targeting of Therapeutic Resistance in Advanced Prostate Cancer
[Molecular Cancer Research] The authors used in vitro and in vivo preclinical MDA prostate cancer PDX models of resistant human prostate cancer to determine molecular mechanisms of cross-resistance between anti-androgen therapy and taxane chemotherapy, underlying the therapeutically resistant phenotype.
From Biology to the Clinic — Exploring Liver Metastasis in Prostate Cancer
[Nature Reviews Urology] Liver metastases are associated with more aggressive tumor biology than lung metastases. Molecular profiling of liver lesions showed an enrichment of low androgen receptor, neuroendocrine phenotypes and high genomic instability.
HIST3H2A Promotes the Progression of Prostate Cancer through Inhibiting Cell Necroptosis
[BMC Cancer] Through bioinformatics analysis, researchers discovered a previously unstudied differential gene called HIST3H2A in prostate cancer (PCa). They revealed that HIST3H2A was highly expressed in PCa tissues, as confirmed by analysis of both the GEO and UALCAN databases.
The Effect of Baseline O2 Conditions on the Response of Prostate Cancer Cells to Hypoxia
[American Journal Of Physiology-Cell Physiology] To determine how the baseline O2 level affected the subsequent response to hypoxia, scientists cultured PC-3 prostate cancer cells in either 18% or 5% O2 for two weeks prior to exposing them to hypoxia for 12-48 hours.
Zeb1-Controlled Metabolic Plasticity Enables Remodelling of Chromatin Accessibility in the Development of Neuroendocrine Prostate Cancer
[Cell Death & Differentiation] Multiomics analyses showed that prostate cancer cells underwent an intermediate state marked by Zeb1 expression with epithelial-mesenchymal transition, stemness, and neuroendocrine features during the development of neuroendocrine prostate cancer.
The Role of Extracellular Vesicles in the Treatment of Prostate Cancer
[Small] The authors discuss the recent advancements in the application of extracellular vesicle (EV) therapies and highlight EV-based functional materials as novel interventions for prostate cancer.
PARP-ish: Gaps in Molecular Understanding and Clinical Trials Targeting PARP Exacerbate Racial Disparities in Prostate Cancer
[Cancer Research] Investigators explore PARP nuclear functions, inhibition, and clinical relevance through the lens of racial differences.
ELK3 Destabilization by Speckle-Type Poz Protein Suppresses Prostate Cancer Progression and Docetaxel Resistance
[Cell Death & Disease] Researchers found that speckle-type POZ protein (SPOP)n and ELK3 were an interacting partner. The interaction between SPOP and ELK3 resulted in increased ELK3 ubiquitination and destruction, assisted by checkpoint kinase-mediated ELK3 phosphorylation.
Phospholipase PLA2G7 Is Complementary to GPX4 in Mitigating Punicic Acid Induced Ferroptosis in Prostate Cancer Cells
[iScience] The authors investigated the mechanisms underlying the toxicity of punicic acid, an isomer of conjugated linolenic acids bearing three conjugated double bonds highly prone to peroxidation, on prostate cancer cells.
Published since 2010, Prostate Cell News compiles top scientific journal articles covering the characterization, behavior, and culturing of prostate cells. Additionally, our editorial team curates the latest press releases, technical advances, jobs, and events relevant to the prostate cell research community. Prostate Cell News saves scientists valuable time while keeping them informed in their field, facilitating the rapid exchange of cutting edge research updates and science news.
