Prostate Cell News

Prostate Cell News is an online resource summarizing the latest prostate cell research.

Retinoblastoma-Associated Protein Is Important for TRIM24-Mediated Activation of the mTOR Signaling Pathway through DUSP2 Action in Prostate Cancer

[Cell Death & Differentiation] Scientists found that the S249/T252 site in RB transcriptional corepressor 1 was key to regulating the transcriptional activity of the tumor-promoting factor TRIM24 in CRPC, as identified through FXXXV mapping.

Thermal Proteome Profiling Strategy Identifies CNPY3 as a Cellular Target of Gambogic Acid for Inducing Prostate Cancer Pyroptosis

[Journal Of Medicinal Chemistry] By using a thermal proteome profiling strategy, investigators revealed that gambogic acid induced pyroptosis by directly targeting the canopy FGF signaling regulator (CNPY3.)

Combined Therapy Targeting AR and EZH2 Curbs Castration-Resistant Prostate Cancer Enhancing Anti-Tumor T-cell Response

[Epigenomics] The authors investigated in vitro and in subcutaneous and spontaneous mouse models the effects of combining enzalutamide and GSK-126, a drug inhibiting the epigenetic modulator EZH2.

A Compound That Inhibits Glycolysis in Prostate Cancer Controls Growth of Advanced Prostate Cancer

[Molecular Cancer Therapeutics] Scientists reported the preclinical activity, safety, and pharmacokinetics of a novel small molecule preclinical candidate, BKIDC-1553, with antiglycolytic activity. A human PDX model implanted in mice and a human organoid was studied for sensitivity to our BKIDC preclinical candidate.

Acetylated KHSRP Impairs DNA-Damage-Response-Related mRNA Decay and Facilitates Prostate Cancer Tumorigenesis

[Molecular Oncology] The authors found that androgen could significantly induce acetylation of far upstream element-binding protein 2 (KHSRP), which intrinsically drove tumor growth in xenografted mice.

State-of-the-Art in Transposable Element Modulation Affected by Drugs in Malignant Prostatic Cancer Cells

[Journal of Cellular Biochemistry] The authors focus on prostate carcinoma cell lines and offer a comprehensive review intended to scrutinize the associations and interactions between transposable elements and genes.

The Prostate Cancer Foundation Announces 2023 Challenge Awards Totaling More Than $21 Million For Prostate Cancer Research

[The Prostate Cancer FoundationThe Prostate Cancer Foundation] The Prostate Cancer Foundation (PCF) today announced the 2023 Class of PCF Team Challenge Award recipients and a total of more than $21 million in funding for innovative prostate cancer research.

$1.25 Million Prostate Cancer Research Grant

[University of Alberta] Prostate cancer research team including Drs. Roseline Godbout, Adam Kinnaird, and Ron Moore have been awarded a $1.25 million, four-year Alberta Cancer Foundation “Game Changer Grant” to investigate the link between fat metabolism and prostate cancer progression.

Dual Deficiency of Melatonin and Dihydrotestosterone Promotes Stromal Cell Damage and Mediates Prostatitis via the cGAS-STING Pathway in Sleep-Deprived Mice

[Cell Communication and Signaling] Sleep deprivation (SD) was utilized to establish a mouse model of insufficient sleep in a special device. Prostatitis was observed at different time points post-SD.

CPT1A Mediates the Succinylation of SP5 Which Activates Transcription of PDPK1 to Promote the Viability and Glycolysis of Prostate Cancer Cells

[Cancer Biology & Therapy] The authors investigated the role of carnitine palmitoyltransferase 1A (CPT1A), which was a succinyltransferase in the progression of prostate cancer. CCK-8 was used to detect the cell viability.

TP63–TRIM29 Axis Regulates Enhancer Methylation and Chromosomal Instability in Prostate Cancer

[Epigenetics & Chromatin] Investigators integrated DNA methylation, RNA-seq, and copy number alterations datasets from The Cancer Genome Atlas, focusing on prostate adenocarcinoma, and employed weighted gene co-expression network analysis.

DHODH Inhibition Represents a Therapeutic Strategy and Improves Abiraterone Treatment in Castration-Resistant Prostate Cancer

[Oncogene] The authors showed that dihydroorotate dehydrogenase (DHODH), an enzyme crucial in the pyrimidine biosynthesis pathway, was a promising therapeutic target for CRPC. The transcript levels of DHODH were significantly elevated in prostate tumors.

Published since 2010, Prostate Cell News compiles top scientific journal articles covering the characterization, behavior, and culturing of prostate cells. Additionally, our editorial team curates the latest press releases, technical advances, jobs, and events relevant to the prostate cell research community. Prostate Cell News saves scientists valuable time while keeping them informed in their field, facilitating the rapid exchange of cutting edge research updates and science news.

spot_img