Volume 6.27 | Jul 24

Prostate Cell News 6.27 July 24, 2015
Prostate Cell News
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“Cancer Driver Gene” Reduces Metastasis in Prostate Cancer
A gene that is responsible for cancer growth plays a totally unexpected role in prostate cancer. The gene Stat3 is controlled by the immune modulator interleukin 6 and normally supports the growth of cancer cells. Researchers discovered a missing link for an essential role of Stat3 and IL-6 signalling in prostate cancer progression. [Press release from Medical University of Vienna discussing online prepublication in Nature Communications] Press Release | Full Article
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PUBLICATIONS (Ranked by impact factor of the journal)

Notch Pathway Inhibition Using PF-03084014, a γ-Secretase Inhibitor (GSI), Enhances the Anti-Tumor Effect of Docetaxel in Prostate Cancer
The effect of PF-03084014 on response to docetaxel was evaluated in docetaxel-sensitive and -resistant castration-resistant prostate cancer cell lines in vitro and in murine models. Impacts on cell proliferation, apoptosis, cancer stem cells and angiogenesis were evaluated. [Clin Cancer Res] Abstract

The Use of Collagen-Based Scaffolds to Simulate Prostate Cancer Bone Metastases with Potential for Evaluating Delivery of Nanoparticulate Gene Therapeutics
Scientists established a 3D cell culture model of prostate cancer bone metastasis using collagen-based scaffolds, characterized this model, and assessed the potential of the model to evaluate delivery of gene therapeutics designed to target bone metastases. [Biomaterials] Abstract

Hypoxia-Inducible miR-182 Enhances HIF1α Signaling via Targeting PHD2 and FIH1 in Prostate Cancer
Overexpression of miR-182 in prostate cancer cells led to a reduction of prolyl hydroxylase domain enzyme 2 (PHD2) and factor inhibiting hypoxia-inducible factor 1 (HIF-1) (FIH1) expression and an increase in HIF1α level either under normoxic or hypoxic condition. [Sci Rep] Full Article

TRAIL-Troglitazone-Induced Apoptosis in Prostate Cancer Cells Involve AMP-Activated Protein Kinase
Since troglitazone is known to activate AMP-activated protein kinase (AMPK), the authors determined whether AMPK is a molecular target mediating this apoptotic cascade by utilizing prostate cancer cell lines stably overexpressing AMPKα1-dominant negative or empty vector. [J Biol Chem] Abstract | Full Article

Delivery of Retinoic Acid to LNCap Human Prostate Cancer Cells Using Solid Lipid Nanoparticles
Anticancer efficiency was evaluated by incubating retinoic acid-solid lipid nanoparticles (SLNs) with human prostate cancer (LNCap) cells, which demonstrated reduced cell viability with increased drug concentrations while blank SLNs displayed negligible cytotoxicity. [Int J Pharm] Abstract

Pituitary Tumor-Transforming Gene 1 Regulates Invasion of Prostate Cancer Cells through MMP13
In vitro, pituitary tumor-transforming gene 1 (Pttg1) activated matrix metalloproteinase 13 (MMP13), which determined prostate cancer (PC) cell invasiveness. However, Pttg1 levels were not significantly affected by MMP13. Furthermore, the Pttg1-activated MMP13 in PC cells was significantly suppressed by inhibition of PI3k/Akt, but not ERK/MAPK or JNK pathways. [Tumour Biol] Abstract

Targeted Nanomedicine for Prostate Cancer Therapy: Docetaxel and Curcumin Co-Encapsulated Lipid–Polymer Hybrid Nanoparticles for the Enhanced Anti-Tumor Activity In Vitro and In Vivo
Docetaxel and curcumin co-encapsulated lipid–polymer hybrid nanoparticles (LPNs) were constructed. The cytotoxicity of the LPNs was evaluated on PC-3 human prostate carcinoma cells by MTT assays. [Drug Deliv] Abstract

The GnRH Antagonist Degarelix Directly Inhibits Benign Prostate Hyperplasia Cell Growth
Benign prostate hyperplasia (BPH)-isolated epithelial and stromal cells were either cultured alone or co-cultured and subsequently treated with increasing concentrations of degarelix. Degarelix treatment induced a decrease in cell viability and cell proliferation rates, which occurred in parallel to an increase in apoptosis. [Horm Metab Res] Abstract


Novel Biomarker Signature that May Predict Aggressive Disease in African American Men with Prostate Cancer
Scientists studied the ethnicity-specific expression of prostate cancer (PC)–associated biomarkers to evaluate whether genetic/biologic factors affect ethnic disparities in PC pathogenesis and disease progression. [J Clin Oncol] Abstract | Press Release

Efficacy of Cabazitaxel in Castration-Resistant Prostate Cancer Is Independent of the Presence of AR-V7 in Circulating Tumor Cells
The authors investigated the association between androgen receptor splice variant 7 (AR-V7) expression in circulating tumor cells and resistance to cabazitaxel. They selected patients with metastatic castration-resistant prostate cancer (mCRPC) from the multicenter, randomized, Phase II, open-label study in mCRPC on the pharmacodynamic effects of budesonide on cabazitaxel. [Eur Urol] Abstract

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MicroRNA in Prostate Cancer: Practical Aspects
The authors surveyed studies conducted on human prostate tissue and biofluids and consolidated trustworthy data on the role of microRNA (miRNA) in the occurrence and progression of prostate cancer (PCa), with a delineation of differentially expressed miRNAs and an analysis of their association with PCa prognosis, progression to castration resistance prostate cancer and metastatic disease, as well as their correlation with response to chemotherapy and hormonal therapy. [Histol Histopathol] Abstract | Full Article

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Damon Runyon Foundation Grants Prestigious Fellowship Awards to 16 Top Young Scientists
The Damon Runyon Cancer Research Foundation named 16 new Damon Runyon Fellows at its spring Fellowship Award Committee review. The recipients of this prestigious, four-year award are outstanding postdoctoral scientists conducting basic and translational cancer research in the laboratories of leading senior investigators across the country. [Damon Runyon Foundation] Press Release

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National Institutes of Health (United States)

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European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW 1st International Nastaran Cancer Symposium 2015
October 1, 2015
Mashhad, Iran

Visit our events page to see a complete list of events in the prostate cell community.
NEW Harry Eagle Scholar Awards for Postdoctoral Candidates (Albert Einstein College of Medicine of Yeshiva University)

Research Assistant/Associate – Computational Biologist (University of Glasgow)

Postdoctoral Positions – Cancer Research (Rutgers University)

Postdoctoral Position – Functional Cancer Genomics (Institute of Oncology Research)

Assistant Professor- Urology (University of California, Los Angeles)

Postdoctoral Fellow- Oncology (Oregon Health & Science University)

Postdoctoral Fellows – Molecular Mechanisms of Prostate Cancer Progression and Therapeutic Resistance (Tulane University School of Medicine)

Postdoctoral Fellowship – Molecular Mechanisms and Translational Investigations of Advanced Prostate Cancer (Cleveland Clinic Lerner Research Institute)

Research Scientists – Tissue Biorepository and Data Resource for Prostate Cancer (NYU Langone Medical Center)

Postdoctoral Technician – Prostate/Breast Cancer (Baylor College of Medicine)

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