Volume 6.10 | Mar 20

Prostate Cell News 6.10 March 20, 2015
Prostate Cell News
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Study Identifies “Lethal” Subtype of Prostate Cancer
Researchers defined a new, distinct subtype of “lethal” prostate cancer marked by the loss of two genes, MAP3K7 and CHD1. They showed that of prostate cancer patients with combination MAP3K7 and CHD1 deletions, about 50 percent will have recurrent prostate cancer, which ultimately leads to death. [Press release from University of Colorado Cancer Center discussing publication in Cancer Research]
Press Release | Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)

The Endogenous Cell-Fate Factor Dachshund Restrains Prostate Epithelial Cell Migration via Repression of Cytokine Secretion via a CXCL Signaling Module
Scientists showed IL-8 and IL-6 secretion was altered ~1000 fold by endogenous Dach1. Endogenous Dach1 is shown to serve as a key endogenous restraint to prostate epithelial cell growth and restrains migration via CXCL signaling. [Cancer Res] Abstract

CCAAT/Enhancer Binding Protein β Controls Androgen-Deprivation-Induced Senescence in Prostate Cancer Cells
Scientists found that CCAAT/enhancer binding protein (C/EBPβ) expression is negatively regulated by androgen receptor activity and that treatment of androgen-sensitive cell lines with anti-androgens increases C/EBPβ mRNA and protein levels. [Oncogene] Abstract

Unravelling “Off-Target” Effects of Redox-Active Polymers and Polymer Multilayered Capsules in Prostate Cancer Cells
Researchers investigated the occurrence of off-target effects in prostate cancer cells following exposure to redox-active polymer and thin multilayer capsules with different chemical properties. [Nanoscale] Abstract

TGFβ-Induced Phosphorylation of Par6 Promotes Migration and Invasion in Prostate Cancer Cells
Scientists investigated the importance of phosphorylated partition-defective 6 (Par6) in prostate cancer. Transforming growth factor β (TGFβ) induced Par6 phosphorylation on Ser345 and its recruitment to the leading edge of the membrane ruffle in migrating prostate cancer cells, where it colocalized with atypical protein kinase Cζ. [Br J Cancer] Abstract

Nano-Targeted Delivery of Toremifene, an Estrogen Receptor-α Blocker in Prostate Cancer
Human prostate cancer cell line PC3M and a nude mouse model were used to test efficacy of nano-targeted and nano-encapsulated toremifene versus free toremifene on the growth and differentiation of tumor cells. [Pharm Res] Abstract

Paradoxical and Contradictory Effects of Imatinib in Two Cell Line Models of Hormone-Refractory Prostate Cancer
Two cell line models of hormone-refractory prostate cancer (DU145 and PC3) were exposed to 20 μM of imatinib for 6-72 hours. Imatinib significantly decreased the viability of DU145 cells but paradoxically augmented the viability of PC3 cells. [Prostate] Abstract

The Role of Tumor Suppressor Gene SOX11 in Prostate Cancer
Scientists investigated the role of SOX11 in prostate cancer and its expression pattern and clinical significance. SOX11 overexpression cell model was used to examine the role of SOX11 in cell growth and metastasis in vitro. [Tumor Biol] Abstract


Prostate Hypofractionated Radiation Therapy with Injection of Hyaluronic Acid: Acute Toxicities in a Phase II Study
In a multicenter Phase II trial, hypofractionated irradiation was combined with an injection of hyaluronic acid to preserve the rectal wall. Tolerance of the injection and acute toxicity rates were reported. [Int J Radiat Oncol Biol Phys] Abstract

Effect of Finasteride on Serum Androstenedione and Risk of Prostate Cancer within the Prostate Cancer Prevention Trial: Differential Effect on High- and Low-Grade Disease
Scientists evaluated the effect of finasteride on serum androst-4-ene-3,17-dione (androstenedione) and its association with prostate cancer risk among subjects who participated in the Prostate Cancer Prevention Trial. [Urology] Abstract

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Inflammation and Prostate Cancer: Friends or Foe?
The authors discuss the role played by the innate and adaptive immune system in the local progression of prostate cancer, and the prognostic information that is currently understood and can be exploited. [Inflamm Res] Abstract

Visit our reviews page to see a complete list of reviews in the prostate cell research field.
Novel Competition Combines Crowdsourcing and Data Sharing to Drive Innovation in Prostate Cancer Research
Industry leaders in biomedical research, oncology data sharing and computational science announced the launch of an innovative research challenge for prostate cancer using previously unavailable clinical data. The Prostate Cancer DREAM Challenge is the first research challenge in prostate cancer to marry crowdsourcing with data sharing, paving a new way to tackle key research questions about metastatic castration-resistant prostate cancer. [Project Data Sphere, LLC (Business Wire)] Press Release

Two Penn Medicine Gene Therapy Researchers Receive Pennsylvania Bio Awards
Two researchers from the Perelman School of Medicine at the University of Pennsylvania will be honored for their contributions for the burgeoning field of gene therapy by Pennsylvania Bio. [Perelman School of Medicine at the University of Pennsylvania] Press Release

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NEW EMBO Workshop – Cellular and Molecular Mechanism of Tumor-Microenvironment Crosstalk
July 9-12, 2015
Tomsk, Russia

NEW Gordon Research Conference – Hormone-Dependent Cancers
August 16-21, 2015
Newry, United States

Visit our events page to see a complete list of events in the prostate cell community.
NEW Postdoctoral Research Associate – Cell Signaling in Prostate Cancer (Heriot-Watt University)

Postdoctoral Fellow – Cancer Biology (Brigham & Women’s Hospital – Harvard Medical School)

Postdoctoral Position – Stem Cell Biology/Cancer Biology (Oregon Health and Science University)

Postdoctoral Research Associate – Prostate Cancer (University of Sydney)

Director – Vector Production (Sangamo BioSciences, Inc.)

Senior Process Development Engineer (Sangamo BioSciences, Inc.)

Postdoctoral Research – Scientist Metabolic Adaptation in Treatment Resistant Prostate Cancer (Cancer Research UK Beatson Institute in Glasgow)

Postdoctoral Position – Molecular Mechanisms and Translational Investigations of Advanced Prostate Cancer (Cleveland Clinic)

Postdoctoral Researcher – Prostate Cancer (University of Pennsylvania)

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