ERG/AKR1C3/AR Constitutes a Feed-Forward Loop for AR Signaling in Prostate Cancer Cells
Researchers found that ERG regulated the expression of the androgen biosynthetic enzyme AKR1C3 in prostate cancer (PCa) cells via direct binding to the AKR1C3 gene. Knockdown of ERG resulted in reduced AKR1C3 expression, which caused a reduction in both DHT synthesis and PSA expression in VCaP PCa cells treated with 5α-androstanedione, a DHT precursor metabolite. [Clin Cancer Res] Abstract
Targeting ASCT2-Mediated Glutamine Uptake Blocks Prostate Cancer Growth and Tumor Development
Researchers demonstrated the glutamine transporter ASCT2 is highly expressed in prostate cancer patient samples. Using LNCaP and PC-3 prostate cancer cell lines, they showed that chemical or shRNA-mediated inhibition of ASCT2 function in vitro decreases glutamine uptake, cell cycle progression through E2F transcription factors, mTORC1 pathway activation and cell growth. [J Pathol] Abstract
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P21 Activated Kinase-1 Mediates Transforming Growth Factor β1-Induced Prostate Cancer Cell Epithelial to Mesenchymal Transition
Scientists determined if P21-activated kinase1 (Pak1), which mediates cytoskeletal remodeling is necessary for the transforming growth factor beta 1 (TGFβ1) induced prostate cancer epithelial-to-mesenchymal transition (EMT). Effects of TGFβ1 on control prostate cancer PC3 and DU145 cells and those with IPA 3 and siRNA mediated Pak1 inhibition were tested for prostate tumor xenograft in vivo and EMT in vitro. [Biochim Biophys Acta] Abstract
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