TRP Channel-Associated Factors Are a Novel Protein Family that Regulates TRPM8 Trafficking and Activity
Researchers identified two previously unknown proteins, which they named “TRP channel-associated factors” (TCAFs), as new TRPM8 partner proteins, and demonstrate that they are necessary for channel function. Functional interaction of TCAF1/TRPM8 leads to a reduction in both the speed and directionality of migration of prostate cancer cells whereas TCAF2 promotes migration. [J Cell Biol] Abstract|Editorial
Role of Diet in Prostate Cancer: The Epigenetic Link
The authors review the evidence that bridges dietary modulation to alterations in the prostate epigenome. They propose that such diet-related effects offer a mechanistic link between the impact of different diets and the course of prostate cancer development and progression. [Oncogene] Full Article
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INDUSTRY NEWS
Sipuleucel-T in Prostate Cancer: Added Benefit Is Not Proven
The German Institute for Quality and Efficiency in Health Care examined in a dossier assessment whether Sipuleucel-T (Provenge) offers patients an added benefit over one of the appropriate comparator therapies. [Institute for Quality and Efficiency in Health Care] Press Release
OncoGenex to Regain Rights to Custirsen from Teva
OncoGenex Pharmaceuticals, Inc. announced that it has executed an initial agreement with Teva Pharmaceutical Industries Ltd. to regain rights to custirsen, an investigational compound currently being evaluated in Phase III clinical development as a treatment for prostate and lung cancers. [OncoGenex Pharmaceuticals, Inc.] Press Release
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