ERG Induces Taxane Resistance in Castration-Resistant Prostate Cancer
Taxanes are the only chemotherapies used to treat patients with metastatic castration-resistant prostate cancer (CRPC). Scientists show that ERG overexpression in in vitro and in vivo models of CRPC is associated with decreased sensitivity to taxanes. [Nat Commun] Full Article
The Long Non-Coding RNA PCAT-1 Promotes Prostate Cancer Cell Proliferation through cMyc12
Researchers describe a role for the oncogenic long non-coding RNAs PCAT-1 in prostate cancer proliferation through cMyc. They found that PCAT-1-mediated proliferation is dependent on cMyc protein stabilization, and using expression profiling, they observed that cMyc is required for a subset of PCAT-1-induced expression changes. [Neoplasia] Full Article
Prostate Cancer Cells Induce Osteoblastic Differentiation via Semaphorin 3A
Researchers investigated whether prostate cancer cells can mediate osteoblastic activity through semaphorin 3A (Sema 3A). They cultured osteoprogenitor MC3T3-E1 cells in prostate cancer-conditioned medium, and analyzed levels of Sema 3A protein in diverse prostate cancer cell lines to identify cell lines in which Sema 3A production showed a positive correlation with osteo-stimulation. [Prostate] Abstract
[18F]Fluoromethylcholine as a Chemotherapy Response Read-Out in Prostate Cancer Cells
The effects of docetaxel and cabazitaxel on viable tumor cell number were explored in four prostate cancer cell lines. Cellular uptake of 2-deoxy-2-[18F]fluoro-D-glucose and [18F]fluoromethylcholine was compared with the effects measured using sulforhodamine B assay, cell counting and colony formation assay, as proximators of viable tumor cell number. [Mol Imaging Biol] Abstract
Role of the Staphylococcal Nuclease and Tudor Domain Containing 1 in Oncogenesis
The staphylococcal nuclease and tudor domain containing 1 (SND1) is a multifunctional protein overexpressed in breast, prostate, colorectal and hepatocellular carcinomas and malignant glioma. The authors describe the crucial role of SND1 in cancer development and progression, and highlight SND1 as a potential target for therapeutic intervention. [Int J Oncol] Abstract
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New Ontario Institute to Tackle Costly Diseases of Aging
The Government of Ontario has awarded new funding to the Ontario Stem Cell Initiative and the Centre for Commercialization of Regenerative Medicine to establish the Ontario Institute for Regenerative Medicine – a research, development and commercialization institute dedicated to the translation of stem cell research into curative therapies for major degenerative diseases. [Ontario Institute for Regenerative Medicine (Marketwire L.P.)] Press Release
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