Luminal Cells Are Favored as the Cell of Origin for Prostate Cancer
Scientists used a novel lineage-tracing strategy to assess the cell of origin in a diverse range of mouse models as well as a hormonal carcinogenesis model. Their results show that luminal cells are consistently the observed cell of origin for each model in situ; however, explanted basal cells from these mice can generate tumors in grafts. [Cell Rep] Full Article|Graphical Abstract
Prostate Cancer Cells Home to Bone Using a Novel In Vivo Model: Modulation by the Integrin Antagonist GLPG0187
Micrometastasis is a barrier to the development of effective cancer therapies for prostate cancer metastasis to bone. Scientists aimed to establish a new model, allowing the tracking of prostate cancer cells homing to bone, and further, to evaluate the response of this approach to therapeutic modulation, using the integrin antagonist GLPG0187. [Int J Cancer] Abstract
miR-130b Suppresses Prostate Cancer Metastasis through Down-Regulation of MMP2
Researchers found that the expression of miR-130b was significantly down-regulated in prostate cancer cell lines and clinical prostate cancer tissues. Enforced over-expression of miR-130b in prostate cancer cells suppressed whereas knock-down of miR-130b increased cell migration and invasion. [Mol Carcinog] Abstract
The Presence of Androgen Receptor Elements Regulates ZEB1 Expression in the Absence of Androgen Receptor
Scientists demonstrate that a promoter construct containing both androgen response elements activates transcription of zinc finger E-box binding homeobox 1 (ZEB1) even in the androgen receptor (AR)-null cell lines DU145 and PC3. Incubation of the AR-positive cell line, LNCaP with R1881, failed to substantially increase the expression levels of ZEB1. [J Cell Biochem] Abstract
Pomegranate and Its Components as Alternative Treatment for Prostate Cancer
The authors discuss data on the effects of pomegranate juice and pomegranate extracts on prostate cancer. They also discuss the effects of specific components of the pomegranate fruit and how they have been used to study the mechanisms involved in prostate cancer progression and their potential to be used in deterring prostate cancer metastasis. [Int J Mol Sci] Abstract|Download Full Article
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