Volume 5.29 | Aug 8

Prostate Cell News 5.29 August 8, 2014
Prostate Cell News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Stromal Fibroblast-Derived miR-409 Promotes Epithelial-to-Mesenchymal Transition and Prostate Tumorigenesis
Ectopic expression of microRNA (miR)-409 in normal prostate fibroblasts conferred a cancer-associated stroma-like phenotype and led to the release of miR-409 via extracellular vesicles to promote tumor induction and epithelial-to-mesenchymal transition in vitro and in vivo. [Oncogene] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
LABORATORY RESEARCH

AKT/GSK-3β Regulates Stability and Transcription of Snail which Is Crucial for bFGF-Induced Epithelial-Mesenchymal Transition of Prostate Cancer Cells
Researchers demonstrate that basic fibroblast growth factor (bFGF) promoted epithelial-mesenchymal transition and motility of human prostate cancer PC-3 cells. [Biochim Biophys Acta] Abstract

Extracellular Iron Diminishes Anticancer Effects of Vitamin C: An In Vitro Study
Investigators show, using two prostate cancer cell lines (LNCaP and PC-3) and primary astrocytes, that the anticancer/cytotoxic effects of ascorbate are completely abolished by iron at physiological concentrations in cell culture medium and human plasma. [Sci Rep] Full Article

Establishment and Characterization of a Highly Tumorigenic African American Prostate Cancer Cell Line, E006AA-hT
Extensive characterization of the E006AA-hT cell line was accomplished using cytodifferentiation and prostate-specific markers, spectral karyotyping, cell line authentication assays, cell proliferation and migration assays, and in vitro tumorigenesis assays. [Int J Biol Sci] Full Article

Crosstalk between Nuclear MET and SOX9/β-Catenin Correlates with Castration Resistant Prostate Cancer
Scientists report the nuclear form of MET (nMET) is essential for castration resistant prostate cancer. Androgen-deprivation induces endogenous nMET and promotes cell proliferation and stem-like cell self-renewal in androgen non-responsive prostate cancer cells. [Mol Endocrinol] Abstract | Full Article

ORCA-010, A Novel Potency Enhanced Oncolytic Adenovirus, Exerts Strong Antitumor Activity in Preclinical Models
The results of in vitro cytotoxicity assays on 15 human cancer cell lines derived from different tumor types demonstrated that ORCA-010 is more potent than Ad5-Δ24RGD or ONYX-015. As ORCA-010 will initially be developed for the treatment of prostate cancer, selectivity experiments were performed using primary human prostate cells. [Hum Gene Ther] Abstract

Polymeric Nanoparticles for Targeted Radiosensitization of Prostate Cancer Cells
The nanoparticles were cytocompatible with immortalized prostate cells. Further, the particles showed a bi-phasic release of encapsulated 8-dibenzothiophen-4-yl-2-morpholin-4-yl-chromen-4-one and were taken up by PC3 prostate cancer cells in a dose- and magnetic field-dependent manner while not being taken up in non-prostate cancer cell lines. [J Biomed Mater Res A] Abstract

The Role of Testicular Nuclear Receptor 4 in Chemo-Resistance of Docetaxel in Castration-Resistant Prostate Cancer
Scientists investigated the role of testicular nuclear receptor 4 (TR4) in docetaxel resistance in castration-resistant prostate cancer. Alternation of TR4 expression in prostate cancer cell line PC3 was applied to find out the influence of TR4 on half-maximal inhibitory concentration, cell viability and cell apoptosis. [Cancer Gene Ther] Abstract

CLINICAL RESEARCH

High-Dose-Rate Brachytherapy as Monotherapy for Prostate Cancer
Investigators reviewed and analyzed the published data on high-dose-rate brachytherapy as monotherapy in the treatment of prostate cancer. [Brachytherapy] Abstract

Abiraterone Acetate and Prednisolone for Metastatic Castration-Resistant Prostate Cancer Failing Androgen Deprivation and Docetaxel-Based Chemotherapy: A Phase II Bridging Study in Korean and Taiwanese Patients
Investigators evaluated the safety and efficacy of abiraterone acetate and prednisolone in Korean and Taiwanese patients with metastatic castration-resistant prostate cancer not responding to docetaxel-based chemotherapy. [Int J Urol] Abstract

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REVIEWS
The Convergence of DNA Damage Checkpoint Pathways and Androgen Receptor Signaling in Prostate Cancer
The authors focus on the connections between checkpoint signaling and the androgen receptor in prostate cancer. They describe what is known about how components of checkpoint signaling regulate androgen receptor activity and what questions still face the field. [Endocr Relat Cancer] Abstract | Full Article

Visit our reviews page to see a complete list of reviews in the prostate cell research field.
 
INDUSTRY NEWS
Generex Announces Publication of AE37 Prostate Cancer Vaccine Study
Generex Biotechnology Corporation announced publication of a follow-up study from a Phase I clinical trial of the immunotherapeutic agent AE37 in patients with prostate cancer. [Generex Biotechnology Corporation] Press Release

UAlbany Biologist Receives $1.43 Million NIH Award for Germline Research to Find Therapies for Cancer and Degenerative Diseases
University at Albany biologist Prashanth Rangan has received a $1.43 million grant from the National Institutes of Health (NIH) for his research into both preventing and inducing differentiation in stem cells in order to treat cancers and degenerative diseases. [University at Albany] Press Release

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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW Advances in Stem Cell Research 2014
September 16-17, 2014
Online

NEW Biology and Treatment of Metastatic Cancers
September 23-26, 2014
El Jadida, Morocco

NEW 14th International Conference Progress in Vaccination against Cancer (PIVAC-14)
September 24-26, 2014
Rome, Italy

Visit our events page to see a complete list of events in the prostate cell community.
 
JOB OPPORTUNITIES
NEW Postdoctoral Position – Molecular Physiology in Prostate Cancer (Duke Molecular Physiology Institute)

NEW Senior Researcher – Interactions between Signaling Pathways of Cytokines, Growth Factors and Androgen Receptors (International Clinical Research Center – St. Anne’s University Hospital)

Postdoctoral Fellow – Cancer and miR Biology (Thomas Jefferson University Hospital)

PhD Position – Prostate Cancer Research (Institute of Oncology Research)

Postdoctoral Position – Cancer Biology/Genomics (Cornell University)

Postdoctoral Research Fellow – Mechanism of Gene Regulation in Prostate Cancer Development and Bone Metastasis (Brigham & Women’s Hospital – Harvard Medical School)

Associate Research Scientist – Molecular Mechanisms that Regulate Prostate Tumor Initiation and Formation of Cancer Stem Cells (Columbia University)

Postdoctoral Fellow – Computational Biology (Netherlands Cancer Institute)

Postdoctoral Fellow – Prostate Cancer Research (Institute of Oncology Research)

Scientist – Prostate Cell Research (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)


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