Volume 5.28 | Aug 1

Prostate Cell News 5.28 August 1, 2014
Prostate Cell News
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The Role of PI3K/AKT-Related PIP5K1α and the Discovery of Its Selective Inhibitor for Treatment of Advanced Prostate Cancer
Scientists report that overexpression of phosphatidylinositol-4-phosphate 5-kinase-α (PIP5K1α) in PNT1A nonmalignant cells resulted in an increased AKT activity and an increased survival, as well as invasive malignant phenotype, whereas siRNA-mediated knockdown of PIP5K1α in aggressive PC-3 cells led to a reduced AKT activity and an inhibition in tumor growth in xenograft mice. [Proc Natl Acad Sci USA] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)

Genetic Ablation of Metadherin Inhibits Autochthonous Prostate Cancer Progression and Metastasis
Researchers demonstrate that direct silencing of metadherin (MTDH) in prostate cancer cells decreased proliferation in vitro and tumor growth in vivo, supporting an epithelial cell-intrinsic role of MTDH in prostate cancer. [Cancer Res] Abstract

Androgen-Regulated microRNA-135a Decreases Prostate Cancer Cell Migration and Invasion Through Downregulating ROCK1 and ROCK2
Using xenograft experiments in chick embryos and adult male mice, researchers showed that miR-135a overexpression decreased in vivo invasion abilities of prostate PC-3 cells. [Oncogene] Abstract

Ion Channel TRPM8 Promotes Hypoxic Growth of Prostate Cancer Cells via an O2-Independent and RACK1-Mediated Mechanism of HIF-1α Stabilization
Scientists identified a mechanistic insight on how TRPM8 promotes the hypoxic growth adaptation of cancer cells via its promotion of RACK1-mediated stabilization of HIF-1α and a potential therapeutic strategy for prostate cancer by targeting TRPM8. [J Pathol] Abstract

Castration-Induced Bone Loss Triggers Growth of Disseminated Prostate Cancer Cells in Bone
Researchers used an in vivo model mimicking androgen ablation to establish the effects of this intervention on disseminated prostate cancer cells in bone. [Endocr Relat Cancer] Abstract

Prostate Cancer Cell Malignancy via Modulation of HIF-1α Pathway with Isoflurane and Propofol Alone and in Combination
The prostate cancer cell line PC3 was exposed to commonly used anesthetic isoflurane and propofol. Malignant potential was assessed through evaluation of expression level of hypoxia-inducible factor-1α (HIF-1α) and its downstream effectors, cell proliferation and migration as well as development of chemoresistance. [Br J Cancer] Abstract

Altered Endosome Biogenesis in Prostate Cancer has Biomarker Potential
A panel of endosomal markers was evaluated by investigators in prostate cancer and non-malignant cells and a significant increase in gene and protein expression was found for early, but not late endosomal proteins.
[Mol Cancer Res]

Inhibition of Hsp90 Augments Docetaxel Therapy in Castrate Resistant Prostate Cancer
Scientists report that a second generation heat shock protein 90 (Hsp90) inhibitor, NVP-AUY922, inhibited cell growth and significantly induced cell death in MYC-CaP/CR and Pten-CaP/cE2 cell lines. [PLoS One]
Full Article

Effect of Lycopene Isolated from Chlorella marina on Proliferation and Apoptosis in Human Prostate Cancer Cell Line PC-3
Scientists assessed the anti-proliferative and apoptotic effect of lycopene from a new source and compared the activity with available trans-lycopene by using androgen-independent human prostate cancer cell lines.
[Tumour Biol]

Knockdown of Ubiquitin Associated Protein 2-Like Inhibits the Growth and Migration of Prostate Cancer Cells
Investigators found that ubiquitin associated protein 2-like (UBAP2L) was expressed in a number of prostate carcinoma cell lines. They report that UBAP2L may play a role in prostate cancer growth and metastasis, and knockdown of UBAP2L by RNA interference may serve as a potential therapeutic approach for prostate cancer. [Oncol Rep] Abstract


Docetaxel Rechallenge in Patients with Metastatic Castration-Resistant Prostate Cancer
Investigators evaluated the benefit of docetaxel rechallenge in patients with metastatic castration-resistant prostate cancer relapsing after an initial good response to first-line doxetaxel. [BJU Int] Abstract

Zoledronic Acid Improves Clinical Outcomes in Patients with Bone Metastatic Hormone-Naïve Prostate Cancer in a Multicenter Clinical Trial
Scientists assessed whether zoledronic acid added to the effect of combined androgen blockade in patients with hormone-naive bone metastatic prostate cancer. [Anticancer Res] Abstract

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Evolving Therapeutic Concepts in Prostate Cancer Based on Genome-Wide Analyses
Although androgen deprivation therapy retains an important role in the management of castration resistant prostate cancer, the authors review a broader spectrum of therapeutic targets that may improve patient response and delay development of advanced disease. [Int J Oncol] Abstract

Visit our reviews page to see a complete list of reviews in the prostate cell research field.
Prostate Cancer Foundation Announces 2014 Movember-PCF Challenge Awards
The Prostate Cancer Foundation (PCF) announced that the partnership with the Movember Foundation has resulted in seven new Challenge Awards for 2014. In total, the 2014 Movember-PCF Challenge Awards will be funding 49 investigators hailing from ten cancer centers across the United States. [Prostate Cancer Foundation]
Press Release

Glide Pharma Takes Exclusive Worldwide Rights to Novel Diagnostic Technology for Prostate Cancer
Glide Pharmaceutical Technologies Ltd. announced that it has taken an exclusive worldwide license to an innovative prostate cancer diagnostic technology from FScan Ltd, a Durham University spin-out company.
[Glide Pharmaceutical Technologies Ltd.]
Press Release

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National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW Global Cancer Conference & Medicare Summit 2014
September 15-17, 2014
Hyderabad, India

NEW FAST 2014: Functional Analysis & Screening Technologies Congress
November 17-19, 2014
Boston, United States

Visit our events page to see a complete list of events in the prostate cell community.
NEW Postdoctoral Fellow – Cancer and miR Biology (Thomas Jefferson University Hospital)

PhD Position – Prostate Cancer Research (Institute of Oncology Research)

Postdoctoral Position – Cancer Biology/Genomics (Cornell University)

Postdoctoral Research Fellow – Mechanism of Gene Regulation in Prostate Cancer Development and Bone Metastasis (Brigham & Women’s Hospital – Harvard Medical School)

Associate Research Scientist – Molecular Mechanisms that Regulate Prostate Tumor Initiation and Formation of Cancer Stem Cells (Columbia University)

Postdoctoral Fellow – Computational Biology (Netherlands Cancer Institute)

Postdoctoral Fellow – Prostate Cancer Research (Institute of Oncology Research)

Postdoctoral Fellow – Translational Prostate Cancer (Cleveland Clinic)

Scientist – Prostate Cell Research (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

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