Monoamine Oxidase A Mediates Prostate Tumorigenesis and Cancer Metastasis
Researchers found that monoamine oxidase A functions to induce epithelial-to-mesenchymal transition and stabilize the transcription factor HIF1α, which mediates hypoxia through an elevation of ROS, thus enhancing growth, invasiveness, and metastasis of prostate cancer cells. [J Clin Invest]
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Nuclear ARRB1 Induces Pseudohypoxia and Cellular Metabolism Reprogramming in Prostate Cancer
Using an integrative approach combining the first genome-wide mapping of chromatin binding for an endocytic adaptor, ARRB1, both in vitro and in vivo with gene expression profiling, scientists demonstrate that nuclear ARRB1 contributes to this metabolic shift in prostate cancer cells via regulation of hypoxia-inducible factor 1A transcriptional activity under normoxic conditions through regulation of succinate dehydrogenase A and fumarate hydratase expression. [EMBO J]
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Metformin Use and Prostate Cancer Risk
Metformin may decrease prostate cancer (PCa) risk by reducing hyperinsulinemia-associated carcinogenesis or through direct effects on cancer cells. Investigators evaluated the association between metformin use and PCa diagnosis. [Eur Urol]
Abstract
REVIEWS
High-Risk Prostate Cancer – Classification and Therapy
The authors critically evaluate the existing literature focused on defining the high-risk population, the management of patients with high-risk prostate cancer, and future directions to optimize care. [Nat Rev Clin Oncol]
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