New Target for Prostate Cancer Resistant to Anti-Hormone Therapies
Prostate cancer becomes deadly when anti-hormone treatments stop working. A new study suggests a way to block the hormones at their entrance. Researchers have found that a protein called BET bromodomain protein 4 binds to the hormone androgen receptor downstream of where current therapies work – targeting androgen receptor signaling. [Press release from the University of Michigan Comprehensive Cancer Center discussing online prepublication in Nature]
Press Release|Abstract
Aldehyde Dehydrogenase 3A1 Associates with Prostate Tumorigenesis
Aldehyde dehydrogenase (ALDH)3A1 expression was analyzed in various prostate cancer (PC) cell lines. In comparison with the non-stem counterparts, a robust upregulation of ALDH3A1 was observed in DU145-derived PC stem cells. [Br J Cancer]
Abstract
Androgen Synthesis Inhibitors in the Treatment of Castration-Resistant Prostate Cancer
The authors review the development of abiraterone and other CYP17 inhibitors; recent studies with abiraterone that inform the understanding of clinical parameters and results of translational studies providing insights into resistance mechanisms to CYP17 inhibitors leading to clinical trials with drug combinations designed to prolong abiraterone benefit or restore abiraterone activity. [Asian J Androl]
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Clinical Trial to Test Modified Citrus Pectin in Prostate Cancer
A Phase III clinical trial conducted at the Meir Medical Center in Kfar-Saba, Israel is recruiting participants to study the effects of dietary supplement PectaSol-C® modified citrus pectin in controlling prostate specific antigen levels in prostate cancer patients. [PR Newswire Association LLC]
Press Release
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