PPAR? vs TR4 Nuclear Receptor Differential Roles in Prostate Cancer and Metabolic Diseases
Peroxisome proliferator-activated receptor ? and TR4 nuclear receptor are two members of the nuclear receptor (NR) superfamily that can be activated by several similar ligands/activators including polyunsaturated fatty acids metabolites including 13-hydroxyoctadecadienoic acid and 15-hydroxyeicosatetraenoic acid, as well as some anti-diabetic drugs thiazolidinediones. However, the consequences of these ligands/activators transactivation via these two NRs are different with at least three distinct phenotypes. [Endocr Relat Cancer] Abstract|Full Article
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