Prostate Development Discovery Could Lead to New Treatments
Scientists discovered how the prostate gland develops for the first time, according to research. The team behind the investigation says the findings could open the door to the development of new therapies for the treatment of prostate cancer. [Press release from the University of York discussing online prepublication in Stem Cell Reports]
Press Release|Full Article|Graphical Abstract
Cofilin Drives Cell Invasive and Metastatic Responses to TGF-ß in Prostate Cancer
Cofilin binding and severing of F-actin is controlled by Ser3 phosphorylation, but the contributions of this step to cell migration during invasion and metastasis of cancer cells are unclear. Researchers addressed the question in prostate cancer cells, including the response to TGF-ß, a critical regulator of migration. [Cancer Res]
Abstract
A Humanized Tissue-Engineered In Vivo Model to Dissect Interactions between Human Prostate Cancer Cells and Human Bone
Investigators introduce a tissue engineering approach to explore the interactions between human tumor cells and a humanized bone microenvironment. Scaffolds, seeded with human primary osteoblasts in conjunction with BMP7, were implanted into immunodeficient mice to form humanized tissue engineered bone constructs (hTEBCs) which consequently resulted in the generation of highly vascularized and viable humanized bone. At 12 weeks, PC3 and LNCaP cells were injected into the hTEBCs. [Clin Exp Metastasis]
Abstract
Src Signaling Pathways in Prostate Cancer
The authors review the discovery and basic biology of c-Src and further discuss the role of Src family kinase inhibitors in the treatment of advanced prostate cancer. [Cancer Metastasis Rev]
Abstract
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