Volume 4.39 | Oct 11

Prostate Cell News 4.39 October 11, 2013
Prostate Cell News
     In this issue: Publications | Reviews | Science News | Industry News | Policy News | Events | Jobs
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TOP STORY
TALEN-Engineered AR Gene Rearrangements Reveal Endocrine Uncoupling of Androgen Receptor in Prostate Cancer
Researchers showed that androgen receptor (AR) gene rearrangements in castration-resistant prostate cancer (CRPC) tissues underlie a completely androgen-independent, yet AR-dependent, resistance mechanism. They discovered intragenic AR gene rearrangements in CRPC tissues, which they modeled using transcription activator-like effector nuclease (TALEN)-mediated genome engineering. [Proc Natl Acad Sci USA]
Abstract | Full Article
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PUBLICATIONS (Ranked by impact factor of the journal)
LABORATORY RESEARCH

Generation of Prostate Tumor-Initiating Cells Is Associated with Elevation of Reactive Oxygen Species and IL6/STAT3 Signaling
In an attempt to establish a human prostate carcinogenesis model, premalignant human prostate EPT2-D5 cells were adapted in protein-free medium and numerous tight prostate spheres (D5HS) were generated in monolayer culture. In contrast to EPT2-D5 cells, the newly generated D5HS efficiently formed large subcutaneous tumors and subsequent metastases in vivo, demonstrating the tumorigenicity of D5HS spheres. [Cancer Res] Abstract

Cabozantinib Inhibits Prostate Cancer Growth and Prevents Tumor-Induced Bone Lesions
Cabozantinib inhibited progression of multiple prostate cancer cell lines in bone metastatic and soft tissue murine models of prostate cancer, except for PC-3 prostate cancer cells in which it inhibited only subcutaneous growth. [Clin Cancer Res] Abstract

HOXB13 Downregulates Intracellular Zinc and Increases NF-κB Signaling to Promote Prostate Cancer Metastasis
Exogenous HOXB13 caused intracellular zinc concentrations to fall in prostate cancer cells, stimulated NF-κB-mediated signaling by reducing inhibitor of NF-κB alpha and enhanced the nuclear translocation of RelA/p65. [Oncogene] Abstract

Cooperative Behavior of the Nuclear Receptor Superfamily and its Deregulation in Prostate Cancer
Scientists assessed the topology of the nuclear receptor (NR) superfamily in normal prostate epithelial cells and its distortion in prostate cancer. Both in vitro and in silico approaches were utilized to profile NRs expressed in non-malignant RWPE-1 cells which were subsequently investigated by treating cells with 132 binary NR ligand combinations. [Carcinogenesis] Abstract

Reversal of Chemosensitivity and Induction of Cell Malignancy of a Non-Malignant Prostate Cancer Cell Line upon Extracellular Vesicle Exposure
Scientists report several phenotypic changes mediated by extracellular vesicle (EVs) isolated from non-malignant and malignant prostate cells as well as patient biopsied prostate tumor samples. EVs can reverse the resistance of prostate cancer cells to camptothecin EVs isolated from non-malignant prostate epithelial cells can reverse soft agar colony formation of malignant DU145 cells, with the reciprocal effect observed. [Mol Cancer] Abstract | Full Article

A Comparative Study of Glycoproteomes in Androgen-Sensitive and -Independent Prostate Cancer Cell Lines
To understand the biochemical meaning of hormone dependency deprivation, glycoproteins enriched profiles were compared between DU145 and LNCaP prostate cancer cells. [Mol Cell Biochem] Full Article

Tumor Necrosis Factor Receptor Associated Factor-4: An Adapter Protein Overexpressed in Metastatic Prostate Cancer Is Regulated by MicroRNA-29a
Researchers investigated the regulatory mechanism of tumor necrosis factor receptor-associated factor 4 (TRAF4) expression in prostate cancer. The expression of TRAF4 mRNA and protein was inversely associated with microRNA-29a expression in prostate cancer cell lines. [Oncol Rep] Abstract

Sodium Meta-Arsenite Induces Reactive Oxygen Species-Dependent Apoptosis, Necrosis, and Autophagy in Both Androgen-Sensitive and Androgen-Insensitive Prostate Cancer Cells
Mechanisms of cell death induced by sodium meta-arsenite were investigated. Sodium meta-arsenite reduced cell viability and increased the sub-G1 population in cell cycle analysis in both androgen-sensitive LNCaP and androgen-insensitive CWR22RV1 cells. [Anticancer Drugs] Abstract

CLINICAL RESEARCH

The Effect of the Frequency and Duration of PSA Measurement on PSA Doubling Time Calculations in Men with Biochemically Recurrent Prostate Cancer
The authors explored whether PSA doubling time calculations are influenced by frequency/duration of PSA measurements, and whether statistical variability leads investigators to find false significant results. [Prostate Cancer P D] Abstract

High Expression of Nucleobindin 2 mRNA: An Independent Prognostic Factor for Overall Survival of Patients with Prostate Cancer
The association of nucleobindin 2 (NUCB2) mRNA expression with overall survival of prostate cancer (PCa) patients was analyzed in this study. The Kaplan-Meier survival analysis showed that the high expression of NUCB2 was related to the poor overall survival of patients with PCa. [Tumor Biol] Abstract

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REVIEWS
Beyond Abiraterone: New Hormonal Therapies for Metastatic Castration-Resistant Prostate Cancer
In this review the development of new hormonal therapies following the arrival of abiraterone for the treatment of prostate cancer will be summarized. [Cancer Biol Ther] Abstract

Visit our REVIEWS page to see a complete list of reviews in the prostate cell research field.
 
SCIENCE NEWS
Prostate Cancer: A Change in Circulating Tumor Cells Detection Has High Potential in the Prediction
A new study revealed that in the prediction of treatment outcome for castration-resistant prostate cancer, a change in circulating tumor cells detection might be more accurate than the change in prostate-specific antigen levels. [Press release from EurekAlert! discussing research presented at the European Association of Urology 13th Central European Meeting, Prague] Press Release

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INDUSTRY NEWS
AstraZeneca Enters Co-Promotion Agreement with Janssen in Japan for Innovative Prostate Cancer Treatment
AstraZeneca announced that it has entered into an agreement with Janssen Pharmaceuticals K. K. in Japan to co-promote abiraterone acetate, an innovative oral therapy for the treatment of patients with prostate cancer. [AstraZeneca] Press Release

Holy Name Medical Center Introduces Radium 223, Xofigo®, Novel Treatment for Prostate Cancer
Holy Name Medical Center’s Cancer Center announced the introduction of Xofigo® for the treatment of select patients with advanced prostate cancer. [Holy Name Medical Center] Press Release
 
POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW ACCryo2014: Advances in Thermal Ablative Therapy & Biopreservation
January 15-19, 2014
Key Largo, United States

Visit our events page to see a complete list of events in the prostate cell community.
 
JOB OPPORTUNITIES
NEW Postdoctoral Researcher – Cancer and Bone Biology (Van Andel Research Institute)

Postdoctoral Fellow – Mechanisms of DNA Damage in the Development and Progression of Prostate Cancer (Johns Hopkins Hospital)

Senior Postdoctoral Researcher – Signaling and Metabolic Alterations in Prostate and Breast Cancer (CIC bioGUNE)

Research Technician Position – Steroid Receptor Signaling (Baylor College of Medicine)

Postdoctoral Research Associates – Tumor Immune Evasion Mechanism and Inflammation (Hollings Cancer Center)

Postdoctoral Fellow – Prostate Cancer and Head & Neck Cancer (University of Maryland Baltimore)

Postdoctoral Position – Prostate Cancer Biology (University Of Rochester School Of Medicine)

Postdoctoral Position – Cancer Genomics and Epigenomics (Ontario Cancer Institute / Princess Margaret Hospital)

Scientist – Particle Chemistry (STEMCELL Technologies Inc.)

Research Technologist – Human Pluripotent Stem Cell Products (STEMCELL Technologies Inc.)

Research Technologist – Cell Culture Media & Matrices (STEMCELL Technologies Inc.)

Research Associate/Scientist – Antibodies Group (STEMCELL Technologies Inc.)

Research Associate – Particle Chemistry (STEMCELL Technologies Inc.)


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