Volume 4.33 | Aug 30

Prostate Cell News 4.33 August 30, 2013
Prostate Cell News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
A Gain-of-Function Mutation in DHT Synthesis in Castration-Resistant Prostate Cancer
Scientists showed that castration-resistant prostate cancer sometimes expresses a gain-of-stability mutation that leads to a gain-of-function in 3ß-hydroxysteroid dehydrogenase type 1, which catalyzes the initial rate-limiting step in conversion of the adrenal-derived steroid dehydroepiandrosterone to dihydrotestosterone (DHT). [Cell] Abstract | Graphical Abstract | Press Release
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PUBLICATIONS (Ranked by impact factor of the journal)
LABORATORY RESEARCH

Targeting the Androgen Receptor with siRNA Promotes Prostate Cancer Metastasis through Enhanced Macrophage Recruitment via CCL2/CCR2-Induced STAT3 Activation
Scientists identified a previously unrecognized regulation: targeting androgen receptor with siRNA in prostate cancer (PCa) cells increased macrophage recruitment via CCL2 up-regulation, which might then result in enhancing PCa invasiveness. [EMBO Mol Med] Abstract | Full Article

The Twist Box Domain Is Required for Twist1-Induced Prostate Cancer Metastasis
Investigators examined a transactivation mutant, Twist1-F191G, in prostate cancer cells using in vitro assays which mimic various stages of metastasis. Twist1 overexpression led to elevated cytoskeletal stiffness and cell traction forces at the migratory edge of cells based on biophysical single-cell measurements. [Mol Cancer Res] Abstract

The Anticancer Effect of Fucoidan in PC-3 Prostate Cancer Cells
Fucoidan induced the apoptosis of PC-3 cells by activating both intrinsic and extrinsic pathways. The induction of apoptosis was accompanied by the activation of extracellular signal-regulated kinase mitogen-activated protein kinase (ERK1/2 MAPK) and the inactivation of p38 MAPK and phosphatidylinositol 3-kinase/Akt. [Mar Drugs] Abstract | Full Article

Inhibition of SIRT6 in Prostate Cancer Reduces Cell Viability and Increases Sensitivity to Chemotherapeutics
Knockdown of SIRT6 in human prostate cancer cells led to sub-G1 phase arrest of cell cycle, increased apoptosis, elevated DNA damage level and decrease in BCL2 gene expression. [Protein Cell] Abstract

Attenuation of Nucleoside and Anti-Cancer Nucleoside Analog Drug Uptake in Prostate Cancer Cells by Cimicifuga racemosa Extract BNO-1055
Scientists investigated the mechanisms underlying the anti-proliferative effects of the ethanolic Cimicifuga racemosa extract BNO-1055 on prostate cells and evaluate its therapeutic potential. BNO-1055 dose-dependently attenuated cellular uptake and incorporation of thymidine and BrdU and significantly inhibited cell growth after long-time exposure. [Phytomedicine] Abstract

Loss of P53 Facilitates Invasion and Metastasis of Prostate Cancer Cells
Researchers found si-P53 promotes the invasion and metastasis in prostate cancer cells, increases the expression and activity of MMP-2/9 and MMP-14. [Mol Cell Biochem] Abstract

miR-205 Is Frequently Downregulated in Prostate Cancer and Acts as a Tumor Suppressor by Inhibiting Tumor Growth
Functional analyses showed that both the overexpression of microRNA-205 (miR-205) and the knockdown of c-SRC in prostate cancer cell lines could inhibit cell growth, colony formation, migration, invasion and the cell cycle as well as induce cell apoptosis in vitro. [Asian J Androl] Full Article

The miRNA let-7a1 Inhibits the Expression of Insulin-Like Growth Factor 1 Receptor (IGF1R) in Prostate Cancer PC-3 Cells
Researchers demonstrated that the growth inhibitory effect of let-7a1 is directly related to targeting IGF1R gene expression in PC-3 cells. [Asian J Androl] Full Article

CLINICAL RESEARCH

Clinical Significance of NUCB2 mRNA Expression in Prostate Cancer
The authors investigated the NUCB2 expression in prostate cancer tissues and adjacent non-cancerous tissues and its potential relevance to clinicopathological variables and prognosis. [J Exp Clin Cancer Res] Full Article

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REVIEWS
Genome-Wide Association Studies on Prostate Cancer: The End or the Beginning?
Currently, more than twenty genome-wide association studies have identified more than fifty common variants associated with susceptibility with prostate cancer. The authors summarize current findings, discuss the common problems troubling current studies and shed light upon possible breakthroughs in the future. [Protein Cell] Abstract

Visit our REVIEWS page to see a complete list of reviews in the prostate cell research field.
 
INDUSTRY NEWS
New Survey Reveals Men Are at Odds with U.S. Preventive Services Task Force Recommendations Against PSA Test
A new survey suggests that men may not always know just what the doctor has ordered when it comes to PSA screening. In a survey of 1,539 men, 80 percent were unaware that the U.S. Preventive Services Task Force has recommended against screening for prostate cancer in healthy men. [Theragenics Corporation] Press Release

Four UCLA Researchers Receive CIRM Early Translational Grants
Four prominent researchers from UCLA’s Eli & Edythe Broad Center of Regenerative Medicine and Stem Cell Research have received Early Translational research awards totaling approximately $13 million from the California Institute for Regenerative Medicine (CIRM), the state stem cell agency. [University of California, Los Angeles] Press Release

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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW 8th National Cancer Research Institute Conference
November 3-6, 2013
Liverpool, United Kingdom

Visit our events page to see a complete list of events in the prostate cell community.
 
JOB OPPORTUNITIES
NEW Postdoctoral Position – Prostate Cancer Biology (University Of Rochester School Of Medicine)

Postdoctoral Position – Cancer Genomics and Epigenomics (Ontario Cancer Institute / Princess Margaret Hospital)

Research Technologist – Human Pluripotent Stem Cell Products (STEMCELL Technologies Inc.)

Postdoctoral Fellow – Prostate Cancer Research (Mount Sinai School of Medicine)

Research Associate II – Anti-Cancer Agents for the Treatment of Prostate Cancer (Johnson & Johnson)

Postdoctoral Position – Prostate Cancer (Tulane University)

Tenure-Track Position – Cell Biologist (McGill University)

Faculty Position – Detection and Diagnosis of Solid Tumors (Stanford University)

Director of Cell Processing Facility (S L Collins Associates, Inc.)


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