Volume 4.14 | Apr 19

Prostate Cell News 4.14 April 19, 2013
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Impaired Expression of Protein Phosphatase 2A Subunits Enhances Metastatic Potential of Human Prostate Cancer Cells through Activation of AKT Pathway
Scientists analyzed the transcriptional and translational expression patterns of individual subunits of the protein phosphatase 2A (PP2A) holoenzyme during prostate cancer (PCa) progression. Through immunohistochemical analysis they observed significantly reduced levels of PP2A-A and -B′γ subunits in PCa specimens compared with benign prostate. [Brit J Cancer] Abstract

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PUBLICATIONS (Ranked by impact factor of the journal)

LABORATORY RESEARCH

Preclinical Evaluation of a Novel 111In-Labeled Bombesin Homodimer for Improved Imaging of GRPR-Positive Prostate Cancer
Scientists present a preclinical study on a novel radiolabeled bombesin homodimer, designated 111In-DOTA-[(Aca-BN(7-14)]2, that was designed for enhanced targeting of gastrin-releasing peptide receptor (GRPR)-positive prostate cancer cells. [Mol Pharmaceut] Abstract

Estrogen Receptor Beta Expression and Androgen Receptor Phosphorylation Correlate with Poor Clinical Outcome in Hormone-Naïve Prostate Cancer and Are Elevated in Castration Resistant Disease
Researchers constructed a tissue microarray consisting of prostate cancer (PC) samples from PC patients and analyzed the androgen receptor (AR) gene copy number, the protein expression profiles of AR, Serin210-phosphorylated AR, estrogen receptor (ER)β, ERα and the proliferation marker Ki67. AR gene amplification was virtually restricted to castration-resistant PC and was significantly associated with increased AR protein expression and higher tumor cell proliferation. [Endocr-Relat Cancer] Abstract

Loss of SUMOylation on ATF3 Inhibits Proliferation of Prostate Cancer Cells by Modulating CCND1/2 Activity
Scientists investigated the role of ATF3 SUMOylation on CCND activity and cellular proliferation in human prostate cancer cells. They showed that ATF3 can be SUMOylated endogenously in the overexpression system, and lysine 42 is the major SUMO site. [Int J Mol Sci]
Abstract | Full Article

Cigarette Smoke Induces Nuclear Translocation of Heme Oxygenase 1 (HO-1) in Prostate Cancer Cells: Nuclear HO-1 Promotes Vascular Endothelial Growth Factor Secretion
The present study explores the relationship between cigarette smoke and nuclear HO-1-modulated promotion of vascular endothelial growth factor secretion. Researchers demonstrated that cigarette smoke medium-induced HO-1 mRNA expression and upregulated HO-1 protein levels in the prostate cancer cell lines DU145 and PC3. [Int J Oncol] Abstract

In Vitro and In Vivo Growth Inhibition of Prostate Cancer by the Small Molecule Imiquimod
Scientists examined in vitro and in vivo antitumor effect of the small molecule imiquimod, also known as a TLR7 agonist, against prostate cancer. Imiquimod inhibited the growth of mouse and human prostate cancer cells. [Int J Oncol] Abstract

miR-154 Inhibits EMT by Targeting HMGA2 in Prostate Cancer Cells
Researchers investigated whether miR-154 plays a critical role in epithelial-mesenchymal transition (EMT) by regulating high-mobility group AT-hook 2 (HMGA2). HMGA2 was upregulated in the prostate cancer tissue samples compared with the adjacent normal ones. [Mol Cell Biochem] Abstract

Retinoic Acid Represses Invasion and Stem Cell Phenotype by Induction of the Metastasis Suppressors RARRES1 and LXN
Scientists identified RARRES1 and LXN as highly significantly downregulated genes in human prostate stem cells, whose expression was induced by the pro-differentiation agent all-trans retinoic acid. [Oncogenesis] Full Article

CLINICAL RESEARCH

Strategy for Detection of Prostate Cancer Based on Relation between Prostate Specific Antigen at Age 40-55 and Long Term Risk of Metastasis: Case-Control Study
Researchers aimed to determine the association between concentration of prostate specific antigen at age 40-55 and subsequent risk of prostate cancer metastasis and mortality in an unscreened population to evaluate when to start screening for prostate cancer and whether rescreening could be risk stratified. [Brit Med J]
Abstract | Press Release | Video

Comparison of 18F-FACBC and 11C-Choline PET/CT in Patients with Radically Treated Prostate Cancer and Biochemical Relapse: Preliminary Results
Investigators assessed the rate of detection rate of recurrent prostate cancer by PET/CT using anti-3-18F-FACBC, a new synthetic amino acid, in comparison to that using 11C-choline as part of an ongoing prospective single-centre study. [Eur J Nucl Med Mol I] Abstract

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REVIEWS

Minireview: Androgen Metabolism in Castration-Resistant Prostate Cancer
This review aims to give a broad outline of steroidogenesis in prostate cancer and to highlight recent developments in understanding resistance to hormonal therapies. [Mol Endocrinol] Abstract

Molecular Mechanisms of Silibinin-Mediated Cancer Chemoprevention with Major Emphasis on Prostate Cancer
The authors report that silibinin has been investigated in a host of cancer models where it exhibits broad-spectrum efficacy against cancer progression both in vitro and in vivo without noticeable toxicity. Specifically in prostate cancer models, silibinin has shown the ability to modulate cell signaling, proliferation, apoptosis, epithelial to mesenchymal transition, invasion, metastasis, and angiogenesis, which taken together provides strong support for silibinin as a candidate prostate cancer chemopreventive agent. [AAPS J] Abstract

Advancing Precision Medicine for Prostate Cancer through Genomics
The authors review potential applications aimed at improving screening specificity in prostate cancer and differentiating aggressive versus indolent prostate cancers. Furthermore, they review predictive biomarker candidates involving ETS gene rearrangements, PTEN inactivation, and androgen receptor signaling. [J Clin Oncol] Abstract

Visit our reviews page to see a complete list of reviews in the prostate cell research field.

INDUSTRY NEWS

Richard Petty Teams Up with Janssen Biotech to Launch Show Your Stripes for Prostate Cancer Awareness
Legendary NASCAR® driver, team owner, and prostate cancer survivor Richard Petty has teamed with Janssen Biotech, Inc. on Show Your Stripes for Prostate Cancer Awareness. This new educational initiative raises awareness about advanced prostate cancer among veterans, their families, friends, and healthcare providers and provides tools to foster dialogue and action against the disease. [Janssen Biotech, Inc.]
Press Release

Premier Prostate Cancer Center the Latest Center to Achieve High Honor of ACR Accreditation
The Premier Prostate Cancer Center, a partnership between AKSM/Oncology and the Urology Care Alliance, is the latest in a rapidly growing list of prostate-only treatment centers to earn the high honor of a three-year term of accreditation in radiation oncology. [PR Newswire Association LLC] Press Release

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POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS

NEW World Biotechnology Congress 2013
June 3-6, 2013
Boston, United States

Visit our
events page to see a complete list of events in the prostate cell community.

JOB OPPORTUNITIES

PhD Studentship – Investigation into Chemokine Receptor Induced Cell Migration (University of East Anglia)

Principal Investigator – Ca2+ Channels on Tumor Angiogenesis (Lille 1 University)

Postdoctoral Research Associate – Prostate Cancer Research (University of Illinois at Chicago)

PhD Studentship – The Role of STEAP2 in Prostate Cancer Invasion and Metastasis (Swansea University)

Researcher – Prostate Cancer (Prostate Cancer UK)

Postdoctoral Position – Tumor-Propagating Cells in Prostate Cancer (University of Georgia)

Postdoctoral Position – Metabolic and Molecular Mechanisms of Advanced Prostate Cancer (Cleveland Clinic)


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