Volume 4.03 | Jan 25

Prostate Cell News 4.03 January 25, 2013
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
DNA Methylation Alterations Exhibit Intraindividual Stability and Interindividual Heterogeneity in Prostate Cancer Metastases
Scientists showed that somatic DNA methylation alterations, despite showing marked interindividual heterogeneity among men with lethal metastatic prostate cancer, were maintained across all metastases within the same individual. [Sci Transl Med] Abstract | Press Release

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PUBLICATIONS (Ranked by impact factor of the journal)

LABORATORY RESEARCH

Myeloid-Specific Expression of Ron Receptor Kinase Promotes Prostate Tumor Growth
Researchers showed that the Ron receptor is expressed in mouse and human stromal cells of the prostate tumor microenvironment. To test the significance of stromal Ron expression, prostate cancer cells were orthotopically implanted into the prostates of either wild type or Ron tyrosine kinase deficient hosts. [Cancer Res] Abstract

HIC1 Modulates Prostate Cancer Progression by Epigenetic Modification
The methylation status of the HIC1 promoter were assayed in cell lines, tissues and plasma of prostate cancer patients by using MSP-PCR and bisulfate sequencing. The ability of HIC1 to regulate proliferation, migration and invasion was assessed by MTT, scratch healing assay and reconstituted extracellular matrices in porous culture chambers. [Clin Cancer Res] Abstract

MicroRNA-182 and MicroRNA-200a Control G-Protein Subunit Alpha-13 (GNA13) Expression and Cell Invasion Synergistically in Prostate Cancer Cells
G-protein coupled receptors signal through heterotrimeric G proteins, and among the different types of G proteins, GNA12/13 have been most closely linked to tumor progression. Investigators explored the role of GNA13 in prostate cancer cell invasion and the mechanism of up-regulation of GNA13 in these cells. [J Biol Chem] Abstract

Targeting Constitutively Activated β1 Integrin Inhibits Prostate Cancer Metastasis
By immunohistochemistry of human tissues, scientists found that levels of β1 integrins and integrin-induced autophosphorylation of FAK are increased in prostate cancer (PCa) cells in primary PCa and lymph node metastases, suggesting that β1 integrin activation occurs in metastatic progression of PCa. [Mol Cancer Res] Abstract

A Feedback Regulation between Kindlin-2 and GLI1 in Prostate Cancer Cells
The authors found that Kindlin-2 promotes GLI1 expression through a mechanism involving GSK3β inactivation and is independent of Smoothened. Functionally, knockdown of Kindlin-2 cooperates with cyclopamine, a Smoothened antagonist, to decrease the viability of prostate cancer cells. [FEBS Lett] Abstract

Prostate Cancer Cells Metabolize D-Lactate inside Mitochondria via a D-Lactate Dehydrogenase which Is More Active and Highly Expressed than in Normal Cells
Although D-lactate metabolism has been shown to occur in a variety of mitochondria, the metabolic fate of D-lactate in cancer cells has never been investigated, as it is believed to be exported to the extracellular phase. Scientists showed that mitochondria from both cancer and normal prostate cells can metabolize D-lactate in an energy competent manner. [FEBS Lett] Abstract

A Novel Canine Model for Prostate Cancer
Researchers sought to develop a canine model of prostate cancer that would more fully represent the features of human prostate cancer than existing models. [Prostate] Abstract

CLINICAL RESEARCH

Repurposing Itraconazole as a Treatment for Advanced Prostate Cancer: A Noncomparative Randomized Phase II Trial in Men With Metastatic Castration-Resistant Prostate Cancer
Researchers conducted a noncomparative, randomized, Phase II study evaluating the antitumor efficacy of two doses of oral itraconazole in men with metastatic prostate cancer. [Oncologist] Abstract

High-Grade Prostate Cancer and Biochemical Recurrence after Radical Prostatectomy among Men Using 5α-Reductase Inhibitors and Alpha-Blockers
Two clinical trials have shown that users of 5α-reductase inhibitors finasteride and dutasteride (5-ARIs) have reduced overall prostate cancer risk, while the proportion of high-grade tumors is increased. The authors studied tumor characteristics, risk of biochemical recurrence and mortality after radical prostatectomy in 5-ARI and alpha-blocker users. [Prostate] Abstract

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REVIEWS
Androgen Receptor Antagonists in Castration-Resistant Prostate Cancer
This review focuses on the androgen receptor (AR) and two direct antagonists, enzalutamide and ARN-509. These next-generation AR antagonists offer great promise for patients with advanced disease. [Cancer J] Abstract
INDUSTRY NEWS

Varian Medical Systems Receives FDA 510(k) Clearance for Vitesse™ Brachytherapy Treatment Planning Software
Varian Medical Systems has received an FDA 510(k) clearance for the latest version of its Vitesse™ real time planning for HDR brachytherapy which is used to plan and perform high-dose-rate (HDR), ultrasound-guided brachytherapy treatments for prostate cancer. [Varian Medical Systems, Inc.] Press Release

Northwestern Medicine Plans $1 Billion Research Investment
Leaders of Northwestern Medicine, comprising Northwestern University Feinberg School of Medicine, Northwestern Medical Faculty Foundation and Northwestern Memorial HealthCare, announced they have made a transformational commitment of more than $1 billion toward creating a leading medical research enterprise on Northwestern’s campus in Chicago’s Streeterville neighborhood. [Northwestern University] Press Release

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS

NEW The 1st Annual World Congress of Geriatrics and Gerontology 2013 (WCGG-2013)
October 12, 2013
Dalian, China

Visit
our events page to see a complete list of events in the prostate cell community.

JOB OPPORTUNITIES

PhD Studentship – Investigation into Chemokine Receptor Induced Cell Migration (University of East Anglia)

Postdoctoral Position – Convergence of the ZMIZ1 and NOTCH1 Pathways at C-MYC in Acute T Lymphoblastic Leukemias (University of Michigan – Ann Arbor)

Postdoctoral Position – Androgen Receptor Genomics (The Netherlands Cancer Institute)

Associate Professor – Urologic Cancers (Oregon Health & Science University [OHSU])

Assistant, Associate or Full Professor – Cancer Early Detection (Stanford University School of Medicine)

Postdoctoral Position – Prostate Cancer Theranostics (The University of Queensland)


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