Volume 3.34 | Sep 7

Prostate Cell News 3.34 September 7, 2012
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Loss of p63 and Its MicroRNA-205 Target Results in Enhanced Cell Migration and Metastasis in Prostate Cancer
Investigators showed that p63 regulates expression of microRNA-205 (miR-205) in prostate cancer cells, and miR-205 is essential for the inhibitory effects of p63 on markers of epithelial-mesenchymal transition, such as ZEB1 and vimentin. [Proc Natl Acad Sci USA] Abstract

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PUBLICATIONS (Ranked by impact factor of the journal)

LABORATORY RESEARCH

Inhibitors of Vacuolar ATPase Proton Pumps Inhibit Human Prostate Cancer Cell Invasion and Prostate-Specific Antigen Expression and Secretion
Investigators studied the effects of inhibiting vacuolar ATPase pumps in androgen-dependent and androgen-independent cells of a human prostate cancer progression model. [Int J Cancer] Abstract

Expression Profile and Functional Activity of Peptide Transporters in Prostate Cancer Cells
Scientists explored the expression profile and functional activity of peptide transporters in the prostate cancer cell lines LNCaP, PC-3 and DU145. [Mol Pharm] Abstract

Proteomic Exploration of the Impacts of Pomegranate Fruit Juice on the Global Gene Expression of Prostate Cancer Cells
Investigators demonstrated that pomegranate fruit juice could effectively hinder the proliferation of human prostate cancer DU145 cells. [Proteomics] Abstract

Copper Modulates Zinc Metalloproteinase-Dependent Ectodomain Shedding of Key Signaling and Adhesion Proteins and Promotes the Invasion of Prostate Cancer Epithelial Cells
Researchers investigated whether copper might regulate the ectodomain shedding of two key cell surface proteins implicated in the invasion and metastasis of prostate cancer and whether the metal was able to influence the invasion of the prostate cancer epithelial cell line PC3. [Mol Cancer Res] Abstract

Protein Arginine Methyltransferase 5 Functions in Opposite Ways in the Cytoplasm and Nucleus of Prostate Cancer Cells
Researchers demonstrated that protein arginine methyltransferase 5 is predominantly localized in the cytoplasm of prostate cancer cells. [PLoS One] Full Article

Xanthohumol Impairs Human Prostate Cancer Cell Growth and Invasion, and Diminishes the Incidence and Progression of Advanced Tumors in TRAMP Mice
Investigators used human hormone-resistant prostate cancer cells as an in vitro model to assess the efficacy of xanthohumol against cell growth, motility and invasion. [Mol Med] Full Article

Treatment with the MEK Inhibitor U0126 Induces Decreased Hyperpolarized Pyruvate to Lactate Conversion in Breast, but Not Prostate, Cancer cells
Scientists monitored the effect of treatment with the mitogen-activated protein kinase (MEK) inhibitor U0126 in prostate and breast cancer cells. [NMR Biomed] Abstract

The Anticancer Effects of Saccharina japonica on 267B1/K-Ras Human Prostate Cancer Cells
Researchers evaluated the potential anticancer effects of Saccharina japonica on 267B1/K-ras human prostate cancer cells. The exposure of cells to the extract induced inhibition of cell growth by increasing the number of apoptotic cells with cell shrinkage and inhibition of cell cycle progression. [Int J Oncol] Abstract

Genome-Wide DNA Methylation Events in TMPRSS2:ERG Fusion Negative Prostate Cancers Implicate an EZH2 Dependent Mechanism with miRNA-26a Hypermethylation
Scientists investigated genome-wide DNA methylation patterns in a large cohort of 51 tumor and 53 benign prostate samples using MeDIP-Seq. [Cancer Discovery] Abstract | Press Release

CLINICAL RESEARCH

High-Dose-Rate Interstitial Brachytherapy as Monotherapy for Clinically Localized Prostate Cancer: Treatment Evolution and Mature Results
Scientists report the clinical outcome of high-dose-rate interstitial brachytherapy as sole treatment for clinically localized prostate cancer. [Int J Radiat Oncol Biol Phys] Abstract

Phase II Trial of RAD001 and Bicalutamide for Castration-Resistant Prostate Cancer
Researchers determined the best overall response and duration of response of RAD001 in combination with bicalutamide in castration-resistant prostate cancer. [BJU Int] Abstract

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REVIEWS
A Perspective on the Role of Estrogen in Hormone-Induced Prostate Carcinogenesis
Androgens are thought to cause prostate cancer, but the precise mechanisms by which they do so are unclear. This review discusses how proof-of-concept studies are needed to definitively test these mechanisms which, if proven, may lead to clinically feasible chemoprevention approaches interfering with these mechanisms. [Cancer Lett] Abstract
INDUSTRY NEWS

Genspera Obtains Authorization for G-202 Phase II Trial in the United kingdom
GenSpera, Inc. announced that the Medicines and Healthcare products Regulatory Agency of the United Kingdom has cleared for the initiation of a phase II human clinical trial of its lead compound, G-202, in the treatment of prostate cancer patients who have failed prior hormonal therapy. [GenSpera, Inc.] Press Release


Prostate Cancer Foundation Announces Nine Challenge Awards

The Prostate Cancer Foundation (PCF) announced that it has funded nine new PCF Challenge Awards in an effort to accelerate scientific discovery and new treatments for prostate cancer patients. [The Prostate Cancer Foundation] Press Release

Aduro Awarded CDMRP Grant for Prostate Cancer Vaccine Development
Aduro BioTech, Inc. announced the award of a congressionally directed medical research programs (CDMRP) grant from the Department of Defense. The grant will be used to complete the preclinical development of a novel therapeutic cancer vaccine for prostate cancer. [Business Wire] Press Release

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS

NEW CellTech 2013
January 22-23, 2013
San Diego, United States

Visit
our events page to see a complete list of events in the prostate cell community.

JOB OPPORTUNITIES

Quality Control Operations Coordinator (STEMCELL Technologies, Inc.)

Scientific Communications & Publishing Coordinator (STEMCELL Technologies, Inc.)


Research Technologist – Research and Development (STEMCELL Technologies, Inc.)

Research Technologist – Media Development (STEMCELL Technologies, Inc.)

Scientist – Mesenchymal Cell Research (STEMCELL Technologies, Inc.)

Postdoctoral Position – Prostate Cancer (BC Cancer Agency)

Postdoctoral Position – Prostate Molecular Oncology (University of Dublin)

Postdoctoral Position – Prostate Cancer Research (University of Texas Southwestern Medical Center)

Postdoctoral Position – Molecular Biomarkers Research for Prostate Carcinoma (University of Genoa)

Research Associate – Quality Assurance (University of California)

Senior Postdoctoral Position – Endocrinology and Therapeutics of Prostate Cancer (Baylor College of Medicine)


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