Volume 3.11 | Mar 23

Prostate Cell News 3.11 March 23, 2012
     In this issue: Publications | Industry News | Policy News | Events | Jobs
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TOP STORY
Stem-Like Cells with Luminal Progenitor Phenotype Survive Castration in Human Prostate Cancer
Scientists demonstrate that in the human prostate cancer (PC) xenograft BM18 pre-existing stem cell-like and neuroendocrine PC cells are selected by castration and survive as totally quiescent. [Stem Cells] Abstract

Detect 7 times more prostate epithelial progenitors with ProstaCult
PUBLICATIONS (Ranked by Impact Factor of the Journal)

LABORATORY RESEARCH

Chemical Castration and Antiandrogens Induce Differential Gene Expression in Prostate Cancer
Researchers report the significantly different effects of an antiandrogen and a GnRH agonist on gene expression in prostate cancer cells. [J Pathol] Abstract

Myb Overexpression Overrides Androgen Depletion-Induced Cell Cycle Arrest and Apoptosis in Prostate Cancer Cells, and Confers Aggressive Malignant Traits: Potential Role in Castration Resistance
Researchers provide the first experimental evidence for a functional role of Myb in growth and malignant behavior of prostate cancer cells and suggest a novel mechanism for castration-resistance. [Carcinogenesis] Abstract

Cadmium Induces p53-Dependent Apoptosis in Human Prostate Epithelial Cells
Researchers investigated the in vitro effects produced by cadmium exposure in normal or tumor cells derived from human prostate epithelium. [PLoS One] Abstract | Press Release


Ursolic Acid Inhibits the Initiation, Progression of Prostate Cancer and Prolongs the Survival of TRAMP Mice by Modulating Pro-Inflammatory Pathways
Using transgenic adenocarcinoma of mouse prostate (TRAMP) mice, the effect of diet enriched with 1% w/w ursolic acid was investigated to evaluate the stage specific chemopreventive activity against prostate cancer. [PLoS One] Abstract

Anti-Androgenic Effects of S-40542, a Novel Non-Steroidal Selective Androgen Receptor Modulator (SARM) for the Treatment of Benign Prostatic Hyperplasia
Researchers’ results indicate that S-40542 possesses the prostate-selective SARM activity, suggestive of clinical benefit against benign prostate hyperplasia. [Prostate] Abstract

Fibronectin Matrix-Mediated Cohesion Suppresses Invasion of Prostate Cancer Cells
Scientists propose a novel role for alpha5beta1 integrin, the principle mediator of fibronectin matrix assembly, as an invasion suppressor of prostate cancer cells. [BMC Cancer] Abstract

Tunicamycin Sensitizes Human Prostate Cells to TRAIL-Induced Apoptosis by Upregulation of TRAIL Receptors and Downregulation of Cellular Inhibitor of Apoptosis 2
Researchers investigated whether tunicamycin can potentiate tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in human prostate cancer cells. [Int J Oncol] Abstract

CLINICAL RESEARCH

Circumcision and the Risk of Prostate Cancer
Researchers hypothesized circumcision may reduce prostate cancer risk. Participant data collected as part of two population-based case-control studies of prostate cancer were analyzed. [Cancer]
Abstract | Press Release

Pretreatment Endorectal Coil Magnetic Resonance Imaging Findings Predict Biochemical Tumor Control in Prostate Cancer Patients Treated with Combination Brachytherapy and External-Beam Radiotherapy
Researchers investigate the utility of endorectal coil magnetic resonance imaging in predicting biochemical relapse in prostate cancer patients treated with combination brachytherapy and external-beam radiotherapy. [Int J Radiat Oncol Biol Phys] Abstract

Serum Sarcosine Increases the Accuracy of Prostate Cancer Detection in Patients with Total Serum Prostate-Specific Antigen Less than 4.0 ng/ml
Scientists assessed the role of serum sarcosine as a biomarker for prostate cancer, as well as any association between sarcosine levels and clinical-pathological parameters. [Prostate] Abstract

Listen Now: New Podcast on ALDH in Breast Cancer Treatment Response

INDUSTRY NEWS

Finasteride (Proscar, Propecia) and Dutasteride (Avodart, Jalyn): May Increase the Risk of High-Grade Prostate Cancer
Health Canada is informing health professionals and the public that the prescription drugs finasteride and dutasteride may be associated with an increased risk of developing a serious form of prostate cancer known as high-grade prostate cancer. [Health Canada] Press Release

UC Health’s Community Benefit Tops $3 Billion
For the first time, University of California (UC) Health has measured the collective impact it has in caring for uninsured patients, educating tomorrow’s health leaders and advancing science to tackle medicine’s toughest challenges. [University of California] Press Release

Province Invests $5 Million in Prostate Centre
British Columbia men are to benefit from a $5-million provincial grant to the Vancouver Prostate Centre, a world leader in research and treatment of prostate cancer. [Vancouver Coastal Health Research Institute, Canada] Press Release

Academic Urology Prostate Center Receives ACR Accreditation
The Prostate Center of Academic Urology has been awarded a three-year term of accreditation in radiation oncology from the American College of Radiology (ACR) and the American Society for Radiation Oncology. [BusinessWire] Press Release

OPKO Health Expands Collaboration with Arctic Partners
OPKO Health, Inc. announced an expansion of the previously announced exclusive licensing deal with Arctic Partners Ab Oy for two biomarkers in the kallikrein family which used together with prostate specific antigen can reduce the need for prostate biopsies by over 50%. [OPKO Health, Inc.] Press Release

Memorial Sloan-Kettering Cancer Center, IBM to Collaborate in Applying Watson Technology to Help Oncologists
Memorial Sloan-Kettering Cancer Center and IBM have agreed to collaborate on the development of a powerful tool built upon IBM Watson in order to provide medical professionals with improved access to current and comprehensive cancer data and practices. [PRNewswire] Press Release

POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
EVENTS
NEW 15th Annual Massachusetts Prostate Cancer Symposium
May 18, 2012
Newton, United States

Visit our events page to see a complete list of events in the prostate cell community.
JOB OPPORTUNITIES

Scientist – hPSC Bioengineering (STEMCELL Technologies, Inc.)

Scientist – Antibody and Hybridoma Technology Platforms (STEMCELL Technologies, Inc.)

Business Analyst – Product Management (STEMSOFT Software, Inc.)

PhD Position – Cell Biology/Infection Research (University of Münster)

Clinical Research Associate (Jennerex Biotherapeutics, Inc.)

Research Associate – Development (Precision Therapeutics, Inc.)

Postdoctoral Fellow (Louisiana State University Health Sciences Center) 


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