Volume 3.05 | Feb 10

Prostate Cell News 3.05 February 10, 2012
     In this issue: Publications | Industry News | Policy News | Events | Jobs
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TOP STORY
Inactivation of Androgen-Induced Regulator ARD1 Inhibits Androgen Receptor Acetylation and Prostate Tumorigenesis
Investigators show that the N-acetyltransferase arrest-defect 1 protein (ARD1) functions as a unique androgen receptor regulator in prostate cancer cells. [Proc Natl Acad Sci USA] Abstract

Free Nature Immunology Webcast: HIV Vaccines.
PUBLICATIONS (Ranked by Impact Factor of the Journal)

LABORATORY RESEARCH

DNA Methylation Silences MiR-132 in Prostate Cancer
To screen for epigenetically silenced microRNAs (miRNAs) in prostate cancer, researchers treated prostate normal epithelial and carcinoma cells with 5-aza-2′-deoxycytidine and subsequently examined expression changes of 650 miRNAs by megaplex stemloop reverse transcription-quantitative PCR. [Oncogene] Abstract

Remarkable Inhibition of mTOR Signaling by the Combination of Rapamycin and 1,4-Phenylenebis(Methylene)Selenocyanate in Human Prostate Cancer Cells
Based on the synthetic organoselenium compound p-XSC’s inhibition of Akt, researchers hypothesized that p-XSC modulates mammalian target of rapamycin (mTOR) C2, an upstream regulator of the kinase. They then further hypothesized that combining p-XSC with rapamycin, an mTORC1 inhibitor, would be an effective combinatory strategy for the inhibition of prostate cancer. [Int J Cancer] Abstract

Androgen-Regulated Transcriptional Control of Sialyltransferases in Prostate Cancer Cells
Investigators demonstrate that GD1a was produced in abundance in cancerous tissue samples from human patients with hormone-sensitive prostate cancers as well as castration-resistant prostate cancers. [PLoS One] Abstract

Caffeic Acid Phenethyl Ester Causes p21Cip1 Induction, Akt Signaling Reduction, and Growth Inhibition in PC-3 Human Prostate Cancer Cells
Researchers find caffeic acid phenethyl ester treatment suppressed proliferation, colony formation, and cell cycle progression in PC-3 human prostate cancer cells. [PLoS One] Abstract

MiR-141 Modulates Androgen Receptor Transcriptional Activity in Human Prostate Cancer Cells through Targeting the Small Heterodimer Partner Protein
Researchers investigated the correlation of small heterodimer partner expression with the cellular level of microR-141 (miR-141) and its effects on androgen receptor transcriptional activity in non-malignant and malignant human prostate epithelial cell lines. [Prostate] Abstract

Regulation of Cell Proliferation through a KIT-Mediated Mechanism in Benign Prostatic Hyperplasia
Scientists investigated the role of the KIT-mediated mechanism in benign prostatic hyperplasia (BPH), and discuss the pathophysiology of BPH and a candidate target of BPH medical therapy. [Prostate] Abstract

Reprogramming of Prostate Cancer-Associated Stromal Cells to Embryonic Stem-Like
In this study CD90+ prostate cancer-associated stromal cells, isolated from tumor tissue of a surgically resected prostate by anti-CD90-mediated sorting and cultured in vitro, were transfected with in vitro packaged lentiviral expression vectors containing stem cell transcription factor genes POU5F1, LIN28, NANOG, and SOX2. [Prostate] Abstract

CLINICAL RESEARCH

Circulating Sphingosine-1-Phosphate and Erythrocyte Sphingosine Kinase-1 Activity as Novel Biomarkers for Early Prostate Cancer Detection
This study has provided a potential mechanism for cancer-related anemia and the first evidence that plasma sphingosine-1-phosphate and erythrocyte sphingosine kinase-1 activity are the potential markers for the diagnosis, monitoring, and predicating for prostate cancer mortality. [Br J Cancer] Abstract

Milk and Dairy Consumption among Men with Prostate Cancer and Risk of Metastases and Prostate Cancer Death
Scientists investigated post-diagnostic milk and dairy intake in relation to risk of lethal prostate cancer (metastases and prostate cancer death) among participants in the Health Professionals Follow-Up Study. [Cancer Epidemiol Biomarkers Prev] Abstract

Androgen Deprivation Therapy for Prostate Cancer Does Not Increase Cardiovascular Mortality in the Long Term
Researchers determine if six months of neo-adjuvant androgen deprivation is associated with the long-term risk of cardiac mortality. [Oncology] Abstract

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INDUSTRY NEWS

International Scientific Cooperation to Advance Image-Guided Prostate Cancer Care
To improve early diagnosis and treatment of prostate cancer, American College of Radiology, AdMeTech Foundation and European Society of Urogenital Radiology have formed a joint effort to expedite development of standards for the Magnetic Resonance Prostate Imaging Reporting and Data System modeled after a successful effort in breast cancer care. [American College of Radiology] Press Release


$30M Gift to Fast-Forward Health Care Research, Education and Care at McMaster University
A Hamilton family is giving McMaster University $30 million to accelerate the university’s innovations in health research, education and care. [McMaster University Press Release] Press Release

POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
EVENTS
NEW American Association for Cancer Research – Mechanisms of Resistance 
May 9-12, 2012 
San Diego, United States

Visit
our events page to see a complete list of events in the prostate cell community.
JOB OPPORTUNITIES

Research and Development Technologist, hPSC Media (STEMCELL Technologies) 

Scientist – Pluripotent Stem Cells (STEMCELL Technologies)

Scientific Marketing Communications Specialist (STEMCELL Technologies Inc.)

Research Technologist, Manufacturing Sciences (STEMCELL Technologies)


Business Analyst – Product Management (STEMSOFT Software)

PhD Position – Cell Biology/Infection Research (University of Munster)

Clinical Research Associate (Jennerex Biotherapeutics, Inc.)


Research Associate – Development (Precision Therapeutics, Inc.)

Postdoctoral Research Fellow – Epidemiology / Prostate Studies (Fred Hutchinson Cancer Research Center)

Postdoctoral Position – Cancer Research (Weill Cornell Medical College and Cold Spring Harbor Laboratory)


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