Volume 2.39 | Oct 21

Prostate Cell News 2.39, October 21, 2011
     In this issue: Publications | Industry News | Policy News | Events | Jobs
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TOP STORIES
Androgen Receptor and Nutrient Signaling Pathways Coordinate the Demand for Increased Amino Acid Transport During Prostate Cancer Progression
Researchers show how prostate cancer cells respond to demands for increased essential amino acids, by coordinately activating amino acid transporter pathways vital for tumor outgrowth. [Cancer Res] Abstract

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PUBLICATIONS (Ranked by Impact Factor of the Journal)

LABORATORY RESEARCH

Highly Sensitive Molecular Diagnosis of Prostate Cancer Using Surplus Material Washed Off from Biopsy Needles
In this study, prostate cancer diagnostic signatures were generated by applying linear discriminant analysis to microarray and real-time RT-PCR data from normal and tumoral prostate tissue samples. [Br J Cancer] Abstract

A Novel Regulation of VEGF Expression by Hypoxia Inducible Factor-1α and STAT3 in HDM2 Transfected Prostate Cancer Cells
On the basis of increasing roles for HDM2 oncoprotein in cancer growth and progression, researchers speculated that HDM2 might play a major role in hypoxia-induced metastatic process. [J Cell Mol Med] Abstract

Hydrogen Sulfide Mediates the Anti-Survival Effect of Sulforaphane on Human Prostate Cancer Cells
Researchers demonstrate that hydrogen sulfide (H2S) mediates the inhibitory effect of sulforaphane on the proliferation of PC-3 cells, which suggests that H2S-releasing diet or drug might be beneficial in the treatment of prostate cancer. [Toxicol Appl Pharmacol] Abstract

Plant Flavone Apigenin Inhibits HDAC and Remodels Chromatin to Induce Growth Arrest and Apoptosis in Human Prostate Cancer Cells: In Vitro and In Vivo Study
Researchers confirm for the first time that apigenin inhibits class I histone deacetylases (HDACs), particularly HDAC1 and HDAC3, and its exposure results in reversal of aberrant epigenetic events that promote malignancy. [Mol Carcinog] Abstract

Testosterone Protects from Metabolic Syndrome-Associated Prostate Inflammation: An Experimental Study in Rabbit
The objective of this study was to determine whether metabolic syndrome-associated prostate alterations are prevented by testosterone supplementation. [J Endocrinol] Abstract

Targeted Expression of E. coli Purine Nucleoside Phosphorylase and Fludara for Prostate Cancer Therapy
The ARR2PB-purine nucleoside phosphorylase/Fludara system induced massive tumor cell death and prolonged life span without systemic cytotoxicity, therefore it might be a more attractive strategy for suicide gene therapy of prostate cancer. [J Gene Med] Abstract

Relationship Between the Localization of Fibroblast Growth Factor 9 in Prostate Cancer Cells and Postoperative Recurrence
The aim of this study was to investigate the role of fibroblast growth factor 9 in postoperative recurrence after radical prostatectomy. [Prostate Cancer Prostatic Dis] Abstract

Aldehyde Dehydrogenase Activity Selects for the Holoclone Phenotype in Prostate Cancer Cells
Researchers examined the interaction between aldehyde dehydrogenase 1 status and the ability to establish a stem cell hierarchy in PC3 prostate cancer cells. [Biochem Biophys Res Commun] Abstract

CLINICAL RESEARCH

Selective Detection of Histologically Aggressive Prostate Cancer: An Early Detection Research Network Prediction Model to Reduce Unnecessary Prostate Biopsies with Validation in the Prostate Cancer Prevention Trial
Subjects undergoing first prostate biopsy enrolled in a multicenter, prospective cohort of the National Cancer Institute Early Detection Research Network (N = 635) were analyzed to develop a model for predicting histologically aggressive prostate cancers. [Cancer] Abstract

Nuclear Magnetic Resonance-Based Metabolomics Enables Detection of the Effects of a Whole Grain Rye and Rye Bran Diet on the Metabolic Profile of Plasma in Prostate Cancer Patients
Researchers sought to identify changes in the metabolic signature of plasma in patients with early-stage prostate cancer (PC) following intervention with a diet rich in whole grain rye and rye bran product (RP) compared with refined white wheat product as a tool for mechanistic investigation of the beneficial health effects of RP on PC progression. [J Nutr] Abstract

A Randomized, Phase II Study of Pazopanib in Castrate-Sensitive Prostate Cancer: A University of Chicago Phase II Consortium/Department of Defense Prostate Cancer Clinical Trials Consortium Study
Researchers hypothesized that pan-inhibition of the vascular endothelial growth factor receptor using pazopanib during the intermittent androgen suppression off period would result in prolonged time to PSA failure. [Prostate Cancer Prostatic Dis] Abstract

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INDUSTRY NEWS

Researching into ‘Starving’ Prostate Cancer Gets Underway
A research program looking at improving the treatment and life expectancy of men with prostate cancer has been awarded almost £100,000. [University of Bristol] Press Release

Mitomics Granted Key Patents in the U.S., Europe, Singapore and New Zealand
Mitomics announced it has received notice from multiple international offices of the issuance of patents protecting key aspects of Mitomics’ flagship product, the Prostate Core Mitomic Test™. [Mitomics] Press Release

POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
EVENTS
NEW European Society for Radiotherapy and Oncology (ESTRO): ESTRO 31
May 9-13, 2012
Barcelona, Spain

Visit
our events page to see a complete list of events in the prostate cell community.
JOB OPPORTUNITIES

Lab Technologist – Tissue Culture (STEMCELL Technologies)

Scientist (iPSC) (STEMCELL Technologies)

Contract Assay Service Technologist (STEMCELL Technologies)

Research and Development Technologist, hPSC Media (STEMCELL Technologies) 

Lab Technologist – Pluripotent Stem Cells (STEMCELL Technologies)

Quality Control Technologist – Cell Separation (STEMCELL Technologies)

Scientist – Pluripotent Stem Cells (STEMCELL Technologies)

Research Associate – Development (Precision Therapeutics, Inc.) 

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