Volume 2.34 | Sep 16

Prostate Cell News 2.34, September 16, 2011
     In this issue: Publications | Industry News | Policy News | Events | Jobs
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TOP STORY
Dual Role of FoxA1 in Androgen Receptor Binding to Chromatin, Androgen Signaling and Prostate Cancer
Researchers report a new paradigm for the forkhead protein FoxA1 action in androgen signaling. [EMBO J] Abstract

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PUBLICATIONS (Ranked by Impact Factor of the Journal)

LABORATORY RESEARCH

Taxane-Induced Blockade to Nuclear Accumulation of the Androgen Receptor Predicts Clinical Responses in Metastatic Prostate Cancer
Researchers report that taxanes inhibit ligand-induced androgen receptor (AR) nuclear translocation and downstream transcriptional activation of AR target genes such as prostate-specific antigen. [Cancer Res] Abstract

Overexpression of Androgen Receptor Enhances the Binding of the Receptor to the Chromatin in Prostate Cancer
The goal was to study the effect of androgen receptor (AR) overexpression on the chromatin binding of the receptor and to identify AR target genes that may be important in the emergence of castration-resistant prostate cancer. [Oncogene] Abstract

Transforming Growth Factor β1 Increase of Hydroxysteroid Dehydrogenase Proteins is Partly Suppressed by Red Clover Isoflavones in Human Primary Prostate Cancer-Derived Stromal Cells
Researchers suggest a pathway connecting overproduction of transforming growth factor-β with increased prostate-specific antigen in prostate cancer. [Carcinogenesis] Abstract

Integrin αv Expression Is Required for the Acquisition of a Metastatic Stem/Progenitor Cell Phenotype in Human Prostate Cancer
Researchers indicate that integrin αv expression is functionally involved in the maintenance of a highly migratory, mesenchymal cellular phenotype as well as the acquisition of a stem/progenitor phenotype in human prostate cancer cells with metastasis-initiating capacity. [Am J Pathol] Abstract

The Impact of Common Genetic Variations in Genes of the Sex Hormone Metabolic Pathways on Steroid Hormone Levels and Prostate Cancer Aggressiveness
In this study, researchers systematically tested the hypothesis that inherited variations in the androgen and estrogen metabolic pathways may be associated with plasma levels of steroid hormones, or prostate cancer aggressiveness at diagnosis. [Cancer Prev Res] Abstract

Dynamic Rewiring of the Androgen Receptor Protein Interaction Network Correlates with Prostate Cancer Clinical Outcomes
Researchers characterized a large panel of novel androgen receptor-interacting proteins, through a combined proteomics/systems biology screen, that are of clinical relevance and could potentially serve as novel markers for diagnosis and prognosis of prostate cancer. [Integr Biol] Abstract

Knockdown of Antizyme Inhibitor Decreases Prostate Tumor Growth In Vivo
To determine whether antizyme inhibitor (AZI) functionally promotes prostate tumor growth, researchers made PC3M-LN4 (human) and AT6.1 (rat) cancer cell lines stably expressing short hairpin RNA to knockdown AZI. [Amino Acids] Abstract

CLINICAL RESEARCH

Single-Port Transvesical Enucleation of the Prostate for Benign Prostatic Hyperplasia with Severe Intravesical Prostatic Protrusion
The objective of this study was to introduce the surgical techniques of a single-port transvesical enucleation of the prostate for enlarged prostates with severe intravesical prostatic protrusion presenting with lower urinary tract symptoms. [World J Urol] Abstract

Toxicity Report of Once Weekly Radiation Therapy for Low-Risk Prostate Adenocarcinoma: Preliminary Results of a Phase I/II Trial
Researchers conducted a multi-institution phase I/II trial of three-dimensional conformal radiation therapy for favourable-risk prostate cancer. [Radiat Oncol] Abstract

Preoperative Weight Change and Risk of Adverse Outcome Following Radical Prostatectomy: Results From the Shared Equal Access Regional Cancer Hospital Database
Researchers examined the relationship between weight change in the year before radical prostatectomy, biochemical recurrence and adverse pathology. [Prostate Cancer Prostatic Dis] Abstract

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INDUSTRY NEWS

Collaborative Agreement – ValiRx to Use Physiomics’ Virtual Tumor Technology to Accelerate Development of Promising Prostate Cancer Drug
Physiomics Plc announced that it has signed a collaborative agreement with a wholly owned subsidiary of ValiRx plc, ValiPharma Limited relating to the further development and accelerated progress of VAL201, ValiPharma’s anti-cancer compound. [Physiomics plc] Press Release

Impax Laboratories Confirms Patent Challenge Relating to Generic JALYN(R) 0.5 mg/0.4 mg
Impax Laboratories, Inc. confirmed that it has initiated a challenge of the patents listed in connection with JALYN(R) (dutasteride and tamsulosin hydrochloride 0.5 mg/0.4 mg) capsules. [Impax Laboratories, Inc.] Press Release

GE Healthcare to Invest $1 Billion in New Oncology Solutions
General Electric (GE) Healthcare announced its plans to dedicate $1 billion of its total R&D budget over the next five years to expand its advanced cancer diagnostic and molecular imaging capabilities, as well as its world-class technologies for the manufacture of biopharmaceuticals and for cancer research. [BusinessWire] Press Release

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS

NEW VI Brazilian Congress on Stem Cells and Cell Therapy
September 28-October 1, 2011
Salvador, Brazil

NEW 1st Annual Congress on Stem Cell Research 
September 28-October 2, 2011 
Sapanca, Turkey 

NEW Select Biosciences STEMCELLS 2012 
February 2-3, 2012 
San Diego, United States 

JOB OPPORTUNITIES

Lab Technologist – Tissue Culture (STEMCELL Technologies)

Scientist (iPSC) (STEMCELL Technologies)

Contract Assay Service Technologist (STEMCELL Technologies)

Research and Development Technologist (STEMCELL Technologies)

Research and Development Technologist, hPSC Media (STEMCELL Technologies) 

Research Associate – Development (Precision Therapeutics, Inc.) 

Postdoctoral Position – Stem Cells and Immunology (University of Connecticut)  

Postdoctoral Fellow in Prostate Cancer Research (University of Texas Southwestern Medical Center)


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