Volume 2.33 | Sep 9

Prostate Cell News 2.33, September 9, 2011
     In this issue: Publications | Industry News | Policy News | Events | Jobs
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TOP STORY

Mast Cell Targeting Hampers Prostate Adenocarcinoma Development but Promotes the Occurrence of Highly Malignant Neuroendocrine Cancers
Researchers underscore the contribution of mast cells (MCs) in tumor progression and uncover a new, opposite role of MCs in protecting against the occurrence of aggressive neuroendocrine variants in prostate cancer. [Cancer Res] Abstract

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PUBLICATIONS (Ranked by Impact Factor of the Journal)

LABORATORY RESEARCH

Polo-Like Kinase 1 Facilitates Loss of Pten-Induced Prostate Cancer Formation
In this study, researchers demonstrate that Pten-depleted cells suffer from mitotic stress, and that nuclear function of Pten, but not its phosphastase activity, is required to reverse this stress phenotype. [J Biol Chem] Abstract

The ß-Catenin Binding Protein ICAT Modulates Androgen Receptor Activity
Researchers investigated inhibitor of ß-catenin and T-cell factor (ICAT), a ß-catenin binding protein that inhibits the canonical Wnt/ß-catenin signaling pathway, in androgen receptor signaling. [Mol Endocrinol] Abstract

Neonatal Exposure to High Doses of 17ß-Estradiol Results in Inhibition of Heparanase-1 Expression in the Adult Prostate
Researchers investigated the expression of heparanase-1 in the ventral prostate of 90-day-old rats after neonatal exposure to a high dose of 17ß-estradiol. [Histochem Cell Biol] Abstract

Contractions of the Mouse Prostate Elicited by Acetylcholine Are Mediated by M3 Muscarinic Receptors
This study investigates the muscarinic receptor subtype responsible for the cholinergic contractile response in the mouse prostate gland. [J Pharmacol Exp Ther] Abstract

Vitamin D3 Cryosensitization Increases Prostate Cancer Susceptibility to Cryoablation via Mitochondrial-Mediated Apoptosis and Necrosis
This study describes a molecular basis of Vitamin D3 cryosensitization including the response and efficacy of the combination in both androgen-sensitive and insensitive prostate cancer. [BJU Int] Abstract

Focal Laser Interstitial Thermotherapy (LITT) at 980nm for Prostate Cancer: Treatment Feasibility in Dunning R3327-AT2 Rat Prostate Tumor
The objective of this study was to examine the feasibility and reproducibility of LITT as a minimally invasive method for the treatment of prostate cancer. [BJU Int] Abstract

CLINICAL RESEARCH

Phase III Trial of Selenium to Prevent Prostate Cancer in Men with High-Grade Prostatic Intraepithelial Neoplasia: South West Oncology Group S9917
In vitro, in vivo, epidemiologic, and clinical trial evidence that selenium supplementation protects against prostate cancer motivated this double-blind, randomized, placebo-controlled trial of selenium 200 (µg/d) as selenomethionine in men with high-grade prostatic intraepithelial neoplasia. [Cancer Prev Res] Abstract

Increased Expression of Putative Cancer Stem Cell Markers in Primary Prostate Cancer is Associated with Progression of Bone Metastases
This current study aimed to test the hypothesis that the development of bone metastasis correlates with the proportion of prostate cancer stem cell-like cells present in the primary tumor. [Prostate] Abstract

Underestimation of Gleason Score at Prostate Biopsy Reflects Sampling Error in Lower Volume Tumors
The objective of this study was to determine the influence of tumor and prostate gland volumes on the underestimation of prostate cancer Gleason score in diagnostic core biopsies. [BJU Int] Abstract 

Diffusion Tensor Imaging of Normal Prostate at 3T: Effect of Number of Diffusion-Encoding Directions on Quantization and Image Quality
The purpose of this study was to prospectively investigate differences of diffusion tensor imaging using a different number of diffusion-encoding directions and to evaluate the feasibility of tractography in healthy prostate at 3T. [Br J Radiol] Abstract

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INDUSTRY NEWS

European Approval for United Kingdom-Discovered Prostate Cancer Drug
A drug that extends life for men with advanced prostate cancer, developed at ICR and The Royal Marsden Hospital, has been approved for use throughout Europe. [The Institute of Cancer Research (ICR) Press Release] Press Release

BioCurex’s RECAFTM Blood Test for Cancer Can Prevent Two Thirds of Unnecessary Prostate Biopsies
BioCurex Inc. announced results indicating that its RECAF blood test for cancer can prevent 70% of unnecessary prostate biopsies. [BioCurex Inc., Press Release] Press Release

CLC bio in $4 Million Project on Molecular Prediction of Prostate Cancer
The Department of Molecular Medicine at Aarhus University Hospital is heading a Danish research project on molecular prediction of prostate cancer risk and aggressiveness, where CLC bio will develop the underlying bioinformatics platform for integrated analysis of microarray data and next generation sequencing data. [CLC bio Press Release] Press Release

Almac-Queen’s Cancer Expert to lead £4.4 Million Collaboration
An investment of £4.4 million in a unique academic-business collaboration between Almac and Queen’s University will help develop better tests for diagnosing and treating prostate, ovarian and breast cancer. [Almac Press Release] Press Release

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS

NEW 6th Annual Congress of the German Society for Stem Cell Research 
November 20-22, 2011 
Düsseldorf, Germany 

NEW Keystone Symposia on Molecular and Cellular Biology – Chemical Biology and Novel Tools in Pharmacology 
February 12-16, 2012 
Santa Fe, New Mexico 

JOB OPPORTUNITIES

Lab Technologist – Tissue Culture (STEMCELL Technologies)

Scientist (iPSC) (STEMCELL Technologies)

Contract Assay Service Technologist (STEMCELL Technologies)

Research and Development Technologist (STEMCELL Technologies)

Research and Development Technologist, hPSC Media (STEMCELL Technologies) 

Prostate Cancer Scientist (McGill University Health Centre) 

Research Associate – Development (Precision Therapeutics, Inc.) 

Postdoctoral Position – Stem Cells and Immunology (University of Connecticut)  

Postdoctoral Fellow in Prostate Cancer Research (University of Texas Southwestern Medical Center)


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