Volume 2.29 | Aug 12

Prostate Cell News 2.29, August 12, 2011
     In this issue: Science News | Current Publications | Industry News | Policy News | Events
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TOP STORY
Overexpression of Fn14 Promotes Androgen Independent Prostate Cancer Progression through Matrix Metalloproteinase-9 and Correlates with Poor Treatment Outcome
Researchers demonstrated the significant role of fibroblast growth factor-inducible 14 (Fn14) in invasion, migration, and proliferation of androgen independent prostate cancer cells. [Carcinogenesis]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

LABORATORY RESEARCH

Selective Changes of Retroelement Expression in Human Prostate Cancer
Researchers investigated expression and DNA methylation of several classes of retroelements in human prostate cancer tissues and cell lines by quantitative RT-PCR and pyrosequencing, respectively. [Carcinogenesis]

Modulation of Androgen Receptor Signaling in Hormonal Therapy-Resistant Prostate Cancer Cell Lines
The aim of the present study was to characterize the androgen receptor response in hormonal therapy-resistant PC346 cells and identify potential disease markers. [PLoS One]

Macrophage Dependent Cleavage of the Laminin Receptor α6β1 in Prostate Cancer
In this present study, researchers utilized a co-culture system of PC-3 prostate tumor cells and macrophages to investigate the hypothesis that macrophages stimulate the production of the pro-metastatic variant α6pβ1 on human prostate cancer cells via the uPA/uPAR axis. [Mol Cancer Res]

A Novel Inhibitor of Hypoxia-Inducible Factor-1α (HIF-1α) P3155 Also Modulates PI3K Pathway and Inhibits Growth of Prostate Cancer Cells
Researchers identified a novel HIF-1α inhibitor P3155 that also modulates PI3K/Akt pathway, which may contribute to its significant in vitro and in vivo antitumor activity. [BMC Cancer]

Prostate Cancer Risk Alleles and Their Associations with Other Malignancies
The objective of this study was to determine whether certain risk alleles are responsible for the relationship between prostate cancer and other malignancies. [Urology]

PSA Affects Prostate Cancer Cell Invasion In Vitro and Induces an Osteoblastic Phenotype in Bone In Vivo
In this study, researchers determined the effects of prostate-specific antigen (PSA) and its precursor, pro-PSA, on invasion and the type of bone metastasis. [Prostate Cancer Prostatic Dis]

Attenuation of IGF-I Receptor Signaling Inhibits Serum-Induced Proliferation of Prostate Cancer Cells
Researchers investigated the effects of a blocking antibody against the insulin-like growth factor-I (IGF-I) receptor (αIR3) on DNA synthesis in prostate cancer cells cultured in the presence of recombinant human IGF-I or normal human serum. [Growth Horm IGF Res]

CLINICAL RESEARCH

Long-Term Quality-of-Life Outcomes after Radical Prostatectomy or Watchful Waiting: The Scandinavian Prostate Cancer Group-IV Randomized Trial
Researchers report results for quality of life for men in the Scandinavian Prostate Cancer Group Study Number IV after a median follow-up of more than 12 years. [Lancet Oncol]

Sunitinib in Combination with Docetaxel and Prednisone in Chemotherapy-Naive Patients with Metastatic, Castration-Resistant Prostate Cancer: a Phase I/II Clinical Trial
This phase I/II study assessed sunitinib combined with docetaxel (Taxotere) and prednisone in chemotherapy-naive metastatic, castration-resistant prostate cancer patients. [Ann Oncol]

Inappropriate Utilization of Radiographic Imaging in Men with Newly Diagnosed Prostate Cancer in the United States
Authors sought to characterize utilization patterns of imaging in men with newly diagnosed prostate cancer. [Cancer]

Prostate Cancer Gene 3 (PCA3) Score Predicts Prostate Biopsy Outcome in Men Receiving Dutasteride for Prevention of Prostate Cancer: Results From the REDUCE Trial
The objective of this study was to examine the ability of the urinary PCA3 assay to predict biopsy-detected cancers in men receiving dutasteride in the Reduction by Dutasteride of Prostate Cancer Events (REDUCE) study cohort. [Urology]

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INDUSTRY NEWS

Prostate Cancer Foundation Funds $9.8 Million in Ten New Challenge Awards for Innovative Research – Awards Will Fast Forward Scientific Discovery and Breakthroughs for Patients with Advanced Disease
The Prostate Cancer Foundation announced that it has funded 10 new Challenge Awards for accelerating scientific discovery and new treatments for prostate cancer patients. [Prostate Cancer Foundation Press Release]

UW Carbone Cancer Researcher Receives $1 Million Award
Researchers have been awarded $1 million over two years to lead research on tracking prostate cancer progression by using novel imaging methods. [University of Wisconsin (UW) Press Release]

Advaxis Granted Pre-IND Meeting with the FDA for Advaxis-PSA Prostate Immunotherapy
Advaxis, Inc. has been granted a pre-Investigational New Drug (IND) meeting with the U.S. Food and Drug Administration (FDA) to discuss the CMC, pharmacology, toxicology, and clinical plans for Advaxis prostate-specific antigen (PSA), its construct to fight prostate cancer. [Advaxis Inc., Press Release]

China Medical Technologies Announces SFDA Approvals for its Prostate Cancer FISH Detection Kit and TOP2A FISH Detection Kit
China Medical Technologies, Inc. announced that it has received approvals for its prostate cancer fluorescent in situ hybridization (FISH) detection kit and Topoisomerase 2-alpha (TOP2A) FISH detection kit from the State Food and Drug Administration (SFDA) of the People’s Republic of China. [China Medical Technologies Inc., Press Release]

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS

NEW 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC ’11) 
August 30 – September 3, 2011 
Boston, United States 

NEW 2nd Annual “Cancer Immunotherapy: A Long-Awaited Reality” Conference  
October 6, 2011 
New York, United States 

NEW 1st International Conference on Stem Cell Research and Applications 
October 7-9, 2011 
Kayseri, Turkey 

NEW 5th Advances in Stem Cell Discovery and Development  
October 19-21, 2011 
San Diego, United States 

JOB OPPORTUNITIES

Lab Technologist – Tissue Culture (STEMCELL Technologies)

Research and Development Technologist, hPSC Media (STEMCELL Technologies)

Scientist (iPSC) (STEMCELL Technologies)

Postdoctoral Position – Endocrinology of Prostate Cancer (Baylor College of Medicine)

Prostate Cancer Scientist (McGill University Health Centre) 

Research Associate – Development (Precision Therapeutics, Inc.) 

Postdoctoral Position – Stem Cells and Immunology (University of Connecticut)  

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