Volume 2.28 | Aug 5

Prostate Cell News 2.28, August 5, 2011
     In this issue: Science News | Current Publications | Industry News | Policy News | Events
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TOP STORY
Transcriptome Sequencing across a Prostate Cancer Cohort Identifies PCAT-1, an Unannotated Long Non-Coding RNA Implicated in Disease Progression
In this study, researchers discover 121 unannotated prostate cancer-associated noncoding RNA transcripts (PCATs) by ab initio assembly of high-throughput sequencing of polyA+ RNA from a cohort of 102 prostate tissues and cells lines. [Nat Biotechnol]

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SCIENCE NEWS
Urine Test Shows Prostate Cancer Risk, U-M Study Finds – Test for Gene Fusion Can Assist in the Early Detection of Prostate Cancer
A new urine test can help aid early detection of and treatment decisions about prostate cancer. [Press release from the University of Michigan (U-M) Comprehensive Cancer Center discussing online prepublication in Science Translational Medicine]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

LABORATORY RESEARCH

Identification of Stromally Expressed Molecules in the Prostate by Tag-Profiling of Cancer-Associated Fibroblasts, Normal Fibroblasts and Fetal Prostate
Researchers have applied next-generation Tag profiling to fetal human prostate, normal human prostate fibroblasts and cancer-associated fibroblasts to identify molecules expressed in prostatic stroma. [Oncogene]

Resistance to CYP17A1 Inhibition with Abiraterone in Castration Resistant Prostate Cancer: Induction of Steroidogenesis and Androgen Receptor Splice Variants
Researchers treated human castration-resistant prostate cancer xenografts with abiraterone and measured tumor growth, tissue androgens, androgen receptor levels, and steroidogenic gene expression vs. controls. [Clin Cancer Res]

Anti-Cancer Effects of Novel Flavonoid Vicenin-2 as a Single Agent and in Synergistic Combination with Docetaxel in Prostate Cancer
The present study was conducted to determine the efficacy of novel flavonoid vicenin-2, an active constituent of the medicinal herb Ocimum Sanctum Linn or Tulsi, as a single agent and in combination with docetaxel in carcinoma of prostate. [Biochem Pharmacol]

Sonoporation Delivery of Interleukin 27 Gene Therapy Efficiently Reduces Prostate Tumor Cell Growth In Vivo
In the present study, researchers examined the efficacy of a new mode of gene delivery to prostate tumors, low-frequency ultrasound irradiation or ‘sonoporation’. [Hum Gene Ther]

Urine TMPRSS2:ERG Fusion Transcript Stratifies Prostate Cancer Risk in Men with Elevated Serum Prostate-Specific Antigen
In this study, researchers report a clinical-grade, transcription-mediated amplification assay to risk stratify and detect prostate cancer noninvasively in urine. [Sci Transl Med]

Castration Resistant Prostate Cancer is Associated with Increased Blood Vessel Stabilization and Elevated Levels of VEGF and Ang-2
This study was performed to investigate blood vessel stabilization and expression of the pro-angiogenic factors vascular endothelial growth factor (VEGF) and Angiopoietin-2 (Ang-2) in castration resistant and hormone naïve prostate cancer. [Prostate]

The H6D Variant of NAG-1/GDF15 Inhibits Prostate Xenograft Growth In Vivo
The objective of the current study is to investigate the activity of non-steroidal anti-inflammatory drug-activated gene (NAG-1) histidine to aspartic acid substitution (H6D) variant in prostate cancer tumorigenesis in vivo. [Prostate]

Prostate Carcinoma Cells LNCaP and Glucan Cooperate in Induction of Cytokine Synthesis by Dendritic Cells: Effect on Natural Killer Cells and CD4+ Lymphocytes Activation
In this study, researchers investigated the effects of glucan on immune cell response to prostate carcinoma. [Prostate]

NMD and MicroRNA Expression Profiling of the Hereditary Prostate Cancer X-Linked 1 Locus Reveal MAGEC1 as a Candidate Prostate Cancer Predisposition Gene
In this study, nonsense-mediated mRNA decay (NMD) inhibition was used for the discovery of truncating mutations. [BMC Cancer]

Heterogeneous Induction of Carcinoma-Associated Fibroblast-Like Differentiation in Normal Human Prostatic Fibroblasts by Co-Culturing with Prostate Cancer Cells
To understand how carcinoma-associated fibroblasts are generated during primary cancer progression, researchers investigated the biochemical characteristics of normal human prostate stromal cells co-cultured with human prostate cancer cells in vitro. [J Cell Biochem]

CLINICAL RESEARCH

Outcomes and Complications After 532 nm Laser Prostatectomy in Anticoagulated Patients With Benign Prostatic Hyperplasia
Researchers explored outcomes and complications after photoselective vaporization of the prostate in an anticoagulated, high risk cohort. [J Urol]

Randomised Clinical Trial: Preventive Treatment with Topical Rectal Beclomethasone Dipropionate Reduces Post-Radiation Risk of Bleeding in Patients Irradiated for Prostate Cancer
The aim of this study was to assess the effect of topical beclomethasone dipropionate in the prevention of radiation-induced proctopathy in patients undergoing radiotherapy for prostate cancer through a double-blind, placebo-controlled, randomised trial. [Aliment Pharmacol Ther]

Associations of Serum Vitamin A and Carotenoid Levels with Markers of Prostate Cancer Detection among US Men
Associations of serum vitamin A and carotenoid levels with markers of prostate cancer detection were evaluated among 3,927 US men, 40-85 years of age, who participated in the 2001-2006 National Health and Nutrition Examination Surveys. [Cancer Causes Control]

Clinicopathological Predictors of Systemic Progression and Prostate Cancer Mortality in Patients with a Positive Surgical Margin at Radical Prostatectomy
Researchers evaluated long-term outcomes of patients with a positive surgical margin at radical prostatectomy and determined predictors of systemic progression and mortality in these men. [Prostate Cancer Prostatic Dis]

INDUSTRY NEWS

Prostate Cancer Foundation Funds $9.8 Million in 10 New Challenge Awards for Innovative Research
The Prostate Cancer Foundation announced that it has funded 10 new Challenge Awards for accelerating scientific discovery and new treatments for prostate cancer patients. [Prostate Cancer Foundation Press Release]

NCCN Receives $2 Million Educational Grant from Pfizer to Support Tailored Quality Improvement Plans at Leading Cancer Centers
The National Comprehensive Cancer Network® (NCCN®) announced the development of the first continuing medical education program to leverage data in the NCCN Oncology Outcomes Database to objectively measure the impact of comprehensive performance improvement on patient outcomes. [National Comprehensive Cancer Network Press Release]

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS

NEW Regenerative Medicine: New Approaches to Healthcare 
September 28, 2011  
New York, United States 

NEW 2011 Maryland Stem Cell Research Symposium 
October 6, 2011 
Towson, United States 

NEW International Conference on Biotechnology and Pharmaceutical Sciences (ICBPS’2011)
October 7-8, 2011 
Pattaya, Thailand 

JOB OPPORTUNITIES

Lab Technologist – Tissue Culture (STEMCELL Technologies)

Research and Development Technologist, hPSC Media (STEMCELL Technologies)

Scientist (iPSC) (STEMCELL Technologies)

Postdoctoral Position – Endocrinology of Prostate Cancer (Baylor College of Medicine)

Prostate Cancer Scientist (McGill University Health Centre) 

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