Volume 2.23 | Jun 24

Prostate Cell News 2.23, June 24, 2011
     In this issue: Science News | Current Publications | Industry News | Policy News | Events
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TOP STORY
IGFBP-3 Is a Metastasis Suppression Gene in Prostate Cancer
To investigate the significance of endogenous insulin-like growth factor binding protein (IFGBP)-3 in the development of prostate cancer (CaP) in vivo scientists crossed IGFBP-3 knockout mice with the Myc model of CaP. [Cancer Res]

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SCIENCE NEWS
Latest Cancer Research Unveiled
A study showed that up to half the number of men with prostate cancer who die do so as a direct result of the disease, rather than from other causes. [Press release from King’s College London discussing research presented at the National Cancer Intelligence Network Conference]

Smoking May Increase Risk of Prostate Cancer Recurrence, Death
Researchers suggest that men with prostate cancer who smoke increase their risk of prostate cancer recurrence and of dying from the disease. [Press release from the Harvard School of Public Health discussing online prepublication in the Journal of the American Medical Association]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

LABORATORY RESEARCH

Exosome Targeting of Tumor Antigens Expressed by Cancer Vaccines Can Improve Antigen Immunogenicity and Therapeutic Efficacy
Researchers confirm that targeting antigen localization to exosomes is a viable approach for improving the therapeutic potential of MVA-BN®-PRO in humans. [Cancer Res]

A Mouse Model of Heterogeneous, c-MYC-Initiated Prostate Cancer with Loss of Pten and p53
Researchers used a new mouse model of prostate cancer that recapitulates several salient features of the human disease to examine the relative rates in which the remaining wild-type alleles of Pten and p53 tumor suppressor genes are lost. [Oncogene]

Regulation of Gene Expression in Prostate Cancer Cells with an Artificially Constructed Promoter Responsive to Radiation
Results suggested that the method used in this study is effective to construct a promoter responsive to stimulation. Such promoters can be used for stimulation-controlled gene therapies. [Gene Ther]

BRCA1 Loss Induces GADD153-Mediated Doxorubicin Resistance in Prostate Cancer
In this study researchers show that BRCA1 plays a central role in the transcriptional response to genotoxic stress in prostate cancer. [Mol Cancer Res]

Metastasis Suppressor KAI1/CD82 Attenuates the Matrix Adhesion of Human Prostate Cancer Cells by Suppressing Fibronectin Expression and β 1 Integrin Activation
Researchers investigated the underlying mechanism of KAI1/CD82-mediated changes in cell adhesion to the extracellular matrix using human prostate cancer cells. [Cell Physiol Biochem]

Stromal Upregulation of Lateral Epithelial Adhesions: Gene Expression Analysis of Signaling Pathways in Prostate Epithelium
The aim of this study was to use microarray analysis to identify significant epithelial signaling pathways and genes in the stromal signaling process. [J Biomed Sci]

CLINICAL RESEARCH

Smoking and Prostate Cancer Survival and Recurrence
Researchers show smoking at the time of prostate cancer diagnosis is associated with increased overall and cardiovascular disease mortality and prostate cancer–specific mortality and recurrence. [JAMA]

Iron Homeostasis and Colorectal Adenoma Risk in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial
Researchers evaluated multiple iron exposure parameters, including dietary intake and serum measures of iron, ferritin, transferrin, total iron binding capacity, and unsaturated iron binding capacity in relation to incident colorectal adenoma in 356 cases and 396 matched, polyp-free controls. [Cancer Prev Res]

Impact of Race on Biochemical Disease Recurrence after Prostate Brachytherapy
In this study, the authors examined the influence of race on biochemical disease-free survival among men who received prostate brachytherapy. [Cancer]

INDUSTRY NEWS

IsoRay Launches National Dual Therapy Study for High Risk Prostate Cancer Focusing on Company’s Cesium-131 Internal Radiation Isotope
IsoRay Inc. announced a new dual therapy study using Cesium-131 brachytherapy (internal radiation therapy) and external beam radiation. [IsoRay Inc., Press Release]

Leaders in Fight Against Cancer Join Historic Initiative Addressing Clinical Investigator Shortage
The Damon Runyon Cancer Research Foundation announced the formation of Accelerating Cancer Cures, a historic collaboration of the biopharmaceutical industry and academia with a strong commitment to achieving key breakthroughs in cancer treatments. [Damon Runyon Cancer Research Foundation Press Release]

Sanofi-Aventis Receives Market Authorization for New Prostate Cancer Treatment
Sanofi-aventis has announced that Health Canada has granted market authorization for Jevtana (cabazitaxel) injection in combination with prednisone for the treatment of patients with metastatic castration resistant (hormone refractory) prostate cancer, previously treated with a docetaxel-containing treatment regimen. [Sanofi-aventis Press Release]

POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
EVENTS

NEW 2011 World Stem Cell Summit  
October 3-5, 2011 
Pasadena, United States 

NEW World Stem Cells & Regenerative Medicine Congress Asia 2011 
October 11-13, 2011 
Singapore, Singapore 

NEW Days of Molecular Medicine 2011 – Re-Engineering Regenerative Medicine 
November 10-12, 2011 
Hong Kong

Visit our events page to see a complete list of events in the prostate cell community.

JOB OPPORTUNITIES

Chemist (STEMCELL Technologies)

Research and Development Senior Technologist (STEMCELL Technologies)

Lab Technologist – Tissue Culture (Maternity Leave) (STEMCELL Technologies)

Research and Development Technologist, hPSC Media (STEMCELL Technologies)

Scientist (iPSC) (STEMCELL Technologies)

Post-doctoral Position – Molecular Biology of Prostate Cancer (Baylor College of Medicine)

Postdoctoral Position – Endocrinology of Prostate Cancer (Baylor College of Medicine)

Assistant/Associate Research Scientist (New York University)


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