Volume 2.19 | May 27

Prostate Cell News 2.19, May 27, 2011
     In this issue: Science News | Current Publications | Industry News | Policy News | Events
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TOP STORY

Cell Autonomous Role of PTEN in Regulating Castration-Resistant Prostate Cancer Growth
Scientists show that castration-resistant growth is an intrinsic property of Pten null prostate cancer cells, independent of cancer development stage. [Cancer Cell]

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SCIENCE NEWS

Pivotal Phase III Study Finds Overall Survival of Patients with Metastatic Castration-Resistant Prostate Cancer Is Significantly Improved with ZYTIGA™ (Abiraterone Acetate)
A study found that patients with metastatic castration-resistant prostate cancer who have received prior chemotherapy containing docetaxel showed a significant improvement in overall survival when treated with ZYTIGA™ (abiraterone acetate) plus prednisone compared to patients treated with prednisone plus placebo. [Press release from Centocor Ortho Biotech Inc. discussing online prepublication in the New England Journal of Medicine]

Apparent Genetic Link to Prostate Cancer in African-American Men Discovered
Some men of African descent may have a higher genetic risk of developing prostate cancer, according to research. [Press release from the University of Southern California discussing online prepublication in Nature Genetics]

Brisk Walking May Help Men with Prostate Cancer, Study Finds
A study of 1,455 U.S. men diagnosed with early-stage prostate cancer has found a link between brisk walking and lowered risk of prostate cancer progression. [Press release from the University of California, San Francisco discussing online prepublication in Cancer Research]

Mushroom Compound Suppresses Prostate Tumors
A mushroom used in Asia for its medicinal benefits has been found to be 100 per cent effective in suppressing prostate tumor development in mice during early trials. [Press release from the Queensland University of Technology discussing online prepublication in PLoS One]

Study Links Acetaminophen to Lower Prostate Cancer Risk
Researchers found that the use of 30 tablets a month or more of acetaminophen for five or more years was associated with an estimated 38% lower risk of prostate cancer. [Press release from American Cancer Society discussing online prepublication in Cancer Epidemiology, Biomarkers and Prevention]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

LABORATORY RESEARCH

Noninvasive Measurement of Androgen Receptor Signaling with a Positron-Emitting Radiopharmaceutical that Targets Prostate-Specific Membrane Antigen
Results establish that relative changes in prostate-specific membrane antigen expression levels can be quantitatively measured using a human-ready imaging reagent and could serve as a biomarker of androgen receptor (AR) signaling to noninvasively evaluate AR activity in patients with castration-resistant prostate cancer. [Proc Natl Acad Sci U S A]

Combination of P13K/mTOR Inhibitors: Antitumor Activity and Molecular Correlates
The PI3K/Akt/mTOR pathway is a major target for cancer therapy. As a strategy to induce the maximal inhibition of this pathway in cancer cells, researchers combined allosteric mTOR inhibitors (rapamycin and RAD001) with a dual PI3K/mTOR kinase inhibitor. [Cancer Res]

Human Tumor Cells Killed by Anthracyclines Induce a Tumor-Specific Immune Response
In this study, scientists investigated the capacity of clinically used chemotherapeutics to induce immunogenic cell death in human tumor cell lines and primary tumor cells. [Cancer Res]

Natura-Alpha Targets Forkhead Box M1 and Inhibits Androgen-Dependent and -Independent Prostate Cancer Growth and Invasion
Natura-alpha could serve as a novel and effective therapeutic agent for treatment of both hormone sensitive and hormone refractory prostate cancer with minimal side effects [Clin Cancer Res]

Berberine Suppresses Androgen Receptor Signaling in Prostate Cancer
In this study, researchers investigated the effect of berberine on androgen receptor signaling in prostate cancer. [Mol Cancer Ther]

Chemopreventive Effect of PSP through Targeting of Prostate Cancer Stem Cell-Like Population
Investigators report that PSP, an active component extracted from the mushroom Turkey tail (Coriolus versicolor), is effective in targeting prostate cancer stem/progenitor cells. [PLoS One]

Inhibition of Histone Deacetylase 1 by Maspin Abrogates Epigenetic Silencing of Glutathione S-Transferase Pi (GSTp) in Prostate Carcinoma Cells
Researchers report that maspin expression in prostate cancer cell line DU145 reversed GSTp DNA methylation, as measured by methylation-specific PCR, MethyLight assay and bisulfite sequencing. [Mol Cancer Res]

CLINICAL RESEARCH

Abiraterone and Increased Survival in Metastatic Prostate Cancer
Scientists evaluated whether abiraterone acetate prolongs overall survival among patients with metastatic castration-resistant prostate cancer who have received chemotherapy. [N Engl J Med]

Genome-Wide Association Study of Prostate Cancer in Men of African Ancestry Identifies a Susceptibility Locus at 17q21
In search of common risk alleles for prostate cancer that could contribute to high rates of the disease in men of African ancestry, investigators conducted a genome-wide association study, with 1,047,986 SNP markers examined in 3,425 African-Americans with prostate cancer (cases) and 3,290 African-American male controls. [Nat Genet]

Physical Activity After Diagnosis and Risk of Prostate Cancer Progression: Data from the Cancer of the Prostate Strategic Urologic Research Endeavor
Researchers prospectively examined vigorous activity and brisk walking after diagnosis in relation to risk of prostate cancer progression among 1,455 men diagnosed with clinically localized prostate cancer. [Cancer Res]

A Large Cohort Study of Long-Term Acetaminophen Use and Prostate Cancer Incidence
Investigators examined the association between acetaminophen use and prostate cancer incidence among 78,485 men in the Cancer Prevention Study II Nutrition Cohort. [Cancer Epidemiol Biom Prev]

INDUSTRY NEWS

Lee W. Wattenberg, M.D., Receives the 2011 AACR Award for Lifetime Achievement in Cancer Prevention Research
Lee W. Wattenberg, M.D., will receive the 2011 AACR Award for Lifetime Achievement in Cancer Prevention Research for his role in launching the field of chemoprevention and his work to understand the potential mechanisms of action of chemopreventive compounds. [American Association for Cancer Research Press Release]

Maryland Stem Cell Research Commission Funds 36 New Projects in FY 2011
The Maryland Stem Cell Research Commission (Commission) has completed its review of the 180 applications received in response to its three FY 2011 Requests for Applications (RFAs). [Maryland Stem Cell Research Fund Press Release]

IRIS International’s NADiA® ProsVue™ Prognostic Prostate Cancer Test Data From Multi-Center Clinical Study Presented at American Urological Association 2011 Annual Meeting
IRIS International, Inc. announced that a poster of the results of a multi-center clinical study utilizing its proprietary NADiA® ProsVue™ prognostic prostate cancer test in 304 post-radical prostatectomy patients, was presented at the American Urological Association 2011 Annual Meeting. [Iris International, Inc. Press Release]

Peregrine Announces Initiation of Phase I/II Prostate Cancer Investigator-Sponsored Trial
Peregrine Pharmaceuticals, Inc. announced the initiation of an investigator-sponsored trial (IST) for patients with castration-resistant prostate cancer. [Peregrine Pharmaceuticals, Inc. Press Release]

POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
EVENTS

NEW Stem Cells USA & Regenerative Medicine Congress
September 12-15, 2011
Boston, United States

NEW World Orphan Drug Congress Asia 2011
September 14-16, 2011
Seoul, Korea

Visit
our events page to see a complete list of events in the prostate cell community.

JOB OPPORTUNITIES
Chemist (STEMCELL Technologies)

Lab Technologist – Cell Separation (STEMCELL Technologies)

Research and Development Senior Technologist (STEMCELL Technologies)

Postdoctoral Position – Endocrinology of Prostate Cancer (Baylor College of Medicine)

Assistant/Associate Research Scientist (New York University)

Postdoctoral Research Associate (Meharry Medical College)

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