Volume 11.23 | Jun 26

Prostate Cell News 11.23 | Jun 26
Prostate Cell News by STEMCELL Technologies
Vol. 11.23 – 26 June, 2020
TOP STORY

The MD Anderson Prostate Cancer Patient-Derived Xenograft Series (MDA PCa PDX) Captures the Molecular Landscape of Prostate Cancer and Facilitates Marker-Driven Therapy Development

Scientists studied two cell line-derived xenografts and the first 80 patient-derived xenografts (PDXs) derived from 47 human prostate cancer donors. Of these, 47 PDXs derived from 22 donors were working models and could be expanded either as cell lines or PDXs.
[Clinical Cancer Research]

Abstract

6253bf96-d7b1-48f0-a3cd-a54f37b3b69e_ON712CXN-organoids-2-645x110
PUBLICATIONSRanked by the impact factor of the journal

Androgen Receptor-Induced Integrin α6β1 and Bnip3 Promote Survival and Resistance to PI3K Inhibitors in Castration-Resistant Prostate Cancer

Integrins α6β1 and Bnip3 were found to promote survival of castration-resistant prostate cancer cells selectively on laminin through the induction of autophagy and mitophagy.
[Oncogene]

Abstract

AR Phosphorylation and CHK2 Kinase Activity Regulates IR Stabilized AR-CHK2 Interaction and Prostate Cancer Survival

The destabilization of androgen receptor-checkpoint kinase 2 (CHK2) interactions induced by CHK2 variants impaired CHK2 negative regulation of cell growth.
[eLife]

Abstract

Small Molecule Inhibitors Targeting Gαi2 Protein Attenuate Migration of Cancer Cells

Researchers observed that two compounds at 10 μΜ significantly inhibited the migratory behavior of the PC3 and DU145 prostate cancer cell lines.
[Cancers]

Full Article

Targeting the ERG Oncogene with Splice-Switching Oligonucleotides as a Novel Therapeutic Strategy in Prostate Cancer

In VCaP prostate cancer cells, both splice-switching oligonucleotides were effective at inducing exon 4 skipping, which resulted in a reduction of overall ERG protein levels up to 96 hours following a single transfection.
[British Journal of Cancer]

Abstract

An Anti-PSMA Immunotoxin Reduces Mcl-1 and Bcl2A1 and Specifically Induces in Combination with the BAD-Like BH3 Mimetic ABT-737 Apoptosis in Prostate Cancer Cells

Combination with the BAD-like mimetic ABT-737 was examined on prostate cancer cells and 3D spheroids and in view of tumor growth and survival in the prostate cancer SCID mouse xenograft model.
[Cancers]

Full Article

The CHK1 Inhibitor MU380 Significantly Increases the Sensitivity of Human Docetaxel-Resistant Prostate Cancer Cells to Gemcitabine through the Induction of Mitotic Catastrophe

CHK1 inhibitors significantly potentiated the sensitivity to gemcitabine in a panel of chemo‐naïve and matched docetaxel‐resistant prostate cancer cell lines under 2D conditions.
[Molecular Oncology]

Abstract

Biological Effect Evaluation of Glutathione-Responsive Cyclodextrin-Based Nanosponges: 2D and 3D Studies

The effect of glutathione-responsive β-cyclodextrin-based nanosponges (GSH-NS) on cell growth was evaluated on multicellular spheroids and a comparison of the GSH-NS cell growth inhibitory activity was performed between 2D and 3D cell cultures.
[Molecules]

Full Article

Inhibition of Notch Pathway Enhances the Anti-Tumor Effect of Docetaxel in Prostate Cancer Stem-Like Cells

The effect of Notch inhibition on response to DOX was evaluated in prostate cancer stem-like cells in vitro and in murine models using a γ-secretase inhibitor, PF-03084014.
[Stem Cell Research & Therapy]

Full Article

Promotion of Epithelial Hyperplasia by interleukin-8-CXCR Axis in Human Prostate

The expression of the IL‐8 axis components was confined to the prostate luminal epithelial cells in both normal and benign prostatic hyperplasia tissues.
[Prostate]

Abstract

E2F7, Regulated by miR‑30c, Inhibits Apoptosis and Promotes Cell Cycle of Prostate Cancer Cells

Transfection of miR‑30c mimicked into prostate cancer cells resulted in reduced cell viability, increased proportion of cells in the G1 phase and higher apoptotic rates.
[Oncology Reports]

Abstract

Virtual Conference Exhibition: Organoids
REVIEWS

Cytokines and Chemokines as Mediators of Prostate Cancer Metastasis

The authors present an overview of the main cytokines/chemokines, including IL-6, CXCL12, TGFβ, CXCL8, VEGF, RANKL, CCL2, CX3CL1, IL-1, IL-7, CXCL1, and CXCL16, that exert modulatory roles in prostate cancer metastasis.
[International Journal of Molecular Sciences]

Full Article

INDUSTRY AND POLICY NEWS

Myovant Sciences Announces Priority Review and FDA Acceptance of New Drug Application for Once-Daily, Oral Relugolix for Advanced Prostate Cancer

Myovant Sciences announced that its New Drug Application for once-daily, oral relugolix for the treatment of men with advanced prostate cancer has been accepted for Priority Review by the FDA.
[Myovant Sciences]

Press Release

NIH’s New Sexual-Harassment Rules Are Still Too Weak, Say Critics

On 24 June, the US National Institutes of Health (NIH) described the actions it will take when alerted to reports of unsafe behavior, including restricting scientists from peer-review panels, holding back pending grants and refusing university requests to transfer funding to other institutions in cases where a harasser changes jobs.
[Nature News]

Editorial

Graduate Programs Drop GRE after Online Version Raises Concerns about Fairness

Scores of academics have raised concerns about the equity of the online version of the test, arguing it disadvantages prospective students from rural and low-income backgrounds. “If I were … a student trying to take this exam, satisfying criteria would be extremely difficult for me,” says Emily Levesque, an assistant professor of astronomy at the University of Washington, Seattle.
[ScienceInsider]

Editorial

FEATURED EVENT

International Society for Stem Cell Research (ISSCR) Virtual Annual Meeting 2020

2020-07-23 – 2020-07-27
Virtual

> See All Events

JOB OPPORTUNITIES

Postdoctoral Position – Cancer Biology

Berlin School of Integrative Oncology Charité – Berlin, Germany

Postdoctoral Studentship – Magnetic Resonance Guided Radiation Therapy on Prostate Cancer

Universitätsklinikum Tübingen – Tübingen, Germany

Postdoctoral Position – 3D Genome Organization in Prostate Cancer

Karolinska Institutet – Solna, Sweden

Postdoctoral Fellow – Prostate Cancer Research

The Vita-Salute San Raffaele University – Milan, Italy

Associate Professor – Prostate Disease Research

Uniformed Services University of the Health Sciences – Bethesda, Maryland, United States

> See All Jobs

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