Volume 1.47 | Dec 10

Prostate Cell News 1.47, December 10, 2010.
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events Subscribe  |  Unsubscribe


Genetic Mutations Associated with Increased PSA and Prostate Cancer 
Austrian researchers have uncovered mutations throughout the mitochondrial genome that are associated with prostate cancer. [Press release from EurekAlert! discussing online prepublication in the American Journal of Human Genetics]



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Supercomputing Research Opens Doors for Drug Discovery
Researchers adapted a widely used existing software to allow supercomputers such as Oak Ridge National Laboratory’s (ORNL) Jaguar to sift through immense molecular databases and pinpoint chemical compounds as potential drug candidates. The project team plans to put the computational development to work on ORNL supercomputers to look for chemicals that could treat prostate cancer. [Oak Ridge National Laboratory Press Release]

Could Alpha-2 Integrin be a Protein Predictor of Tumor Spread?
Researchers have generated data that lead them to suggest that decreased expression of the protein alpha-2 integrin is predictive of tumor dissemination to distant sites and decreased survival in individuals with either breast or prostate cancer. [Press release from Medical News Today discussing online prepublication in the Journal of Clinical Investigation]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)


Somatic Mutations throughout the Entire Mitochondrial Genome Are Associated with Elevated PSA Levels in Prostate Cancer Patients
Researchers sequenced the entire mitochondrial genome (16,569 bp) from 30 prospectively collected pairs of macrodissected cancerous and benign cells from prostate cancer patients and compared their genetic variability. [Am J Hum Genet]

Invasive Prostate Carcinoma Driven by c-Src and Androgen Receptor Synergy
Researchers analyzed over-expression of cellular Src (c-Src) in naïve mouse prostate epithelium and observed no change in tubule formation frequency or histological structure. [Cancer Res]

Tyramide Signal Amplification for Antibody-Overlay Lectin Microarray: A Strategy to Improve the Sensitivity of Targeted Glycan Profiling
Here, researchers describe a new Tyramide Signal Amplification (TSA) for Antibody-overlay Lectin Microarray procedure for sensitive profiling of glycosylation patterns. Researchers demonstrated that TSA increased the sensitivity of the microarray over 100 times for glycan profiling using the model protein prostate specific antigen. [J Proteome Res]

Toward an Automatic Method for Extracting Cancer- and Other Disease-Related Point Mutations from the Biomedical Literature
Researchers introduce a high-throughput computational method for the identification of relevant disease mutations in Pub-Med abstracts applied to prostate and breast cancer mutations. [Bioinformatics]

Leptin Signaling and Apoptotic Effects in Human Prostate Cancer Cell Lines
This research studied leptin-induced signaling and apoptosis in androgen sensitive (LNCaP, PC3/AR) and insensitive (PC3, DU145) prostate cancer cell lines. [Prostate]

Anti-Angiogenic Effects and Mechanism of Prazosin
Alpha1-adrenoceptors antagonists (doxazosin, terazosin, prazosin) are commonly prescribed for benign prostate hyperplasia and hypertension. Doxazosin and terazosin exhibit anti-angiogenic effects and apoptotic activities against multiple cell types and are potential preventive agents for prostate cancer. Prazosin induces apoptosis in three prostate cancer cell lines. Researchers hypothesized that prazosin, a more potent alpha1-adrenoceptor antagonist with a distinct mechanism, exhibits anti-angiogenic activity. [Prostate]

Elevated GnRH Receptor Expression Plus GnRH Agonist Treatment Inhibits the Growth of a Subset of Papillomavirus 18-Immortalized Human Prostate Cells
Engineered high-level GnRH receptor activation inhibits growth of a subset of papillomavirus-immortalized prostate cells. Elucidating mechanisms leading to clone-specific differences in cell surface GnRH receptor levels is a valuable next step in developing strategies to exploit prostate cell anti-proliferation using GnRH agonists. [Prostate]


Impact of Age at Diagnosis on Prostate Cancer Treatment and Survival
Older patients are more likely to have high-risk prostate cancer at diagnosis and less likely to receive local therapy. Indeed, underuse of potentially curative local therapy among older men with high-risk disease may in part explain observed differences in cancer-specific survival across age strata. [J Clin Oncol]

Regulation of HMGA1 Expression by microRNA296 Affects Prostate Cancer Growth and Invasion
In this study, researchers examined the functional relation between miR-296 and high mobility group AT-hook 1 (HMGA1) expression in several prostate cancer cell lines and a large prostate cancer cohort. [Clin Cancer Res]


Bavarian Nordic Receives Special Protocol Assessment Agreement from the FDA for Phase III Trial of PROSTVAC®
Bavarian Nordic A/S announced that the company has received a letter of concurrence from the U.S. Food and Drug Administration (FDA) on a Special Protocol Assessment for a Phase III study required for product registration for its product candidate, PROSTVAC®, for the treatment of patients with asymptomatic or minimally symptomatic metastatic castration-resistant prostate cancer. [Thomson Reuters]

EVENTS (Listed by Date)

The 3rd Guangzhou International Conference on Stem Cell Biology and Regenerative Medicine
December 17-19, 2010
Guangzhou, China

American Association for Cancer Research (AACR) Targeting PI3K/mTOR Signaling in Cancer
February 24-27, 2011
San Francisco, United States

NEW Cell Culture World Congress 2011 – Optimising Cell Culture Development for Biopharmaceutical, Bioprocessing and Manufacture
February 28-March 2, 2011
Munich, Germany

American Association for Cancer Research (AACR) Stem Cells, Development, and Cancer
March 3-6, 2011
Vancouver, Canada

MENA Oncology Conference
March 11-12, 2011
Cairo, Egypt

NEW PITTCON Conference & Expo 2011
March 13-18, 2011
Atlanta, United States

The 6th International Conference on Oncolytic Viruses as Cancer Therapeutics
March 16-19, 2011
Las Vegas, United States

United Kingdom National Stem Cell Network 2011 Annual Scientific Conference
March 30-April 1, 2011
York, United Kingdom

American Association for Cancer Research (AACR) 102nd Annual Meeting 2011
April 2-6, 2011
Orlando, United States

NEW World Stem Cells & Regenerative Medicine Congress 2011
May 9-11, 2011
London, United Kingdom

International Society for Stem Cell Research (ISSCR) 9th Annual Meeting
June 15-18, 2011
Toronto, Canada

National Cancer Institute (NCI) Cancer Research Imaging Camp
June 19-24, 2011
St. Louis, United States

4th Annual Advances in Biodetection & Biosensors Conference and Exhibition
June 30-July 1, 2011
Hamburg, Germany

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.


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