Volume 1.45 | Nov 26

Prostate Cell News 1.45, November 26, 2010.
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events Subscribe  |  Unsubscribe

TOP STORY

The Retinoblastoma Tumor Suppressor Controls Androgen Signaling and Human Prostate Cancer Progression 
Here, researchers have identified a critical role for retinoblastoma in protecting against tumor progression through regulation of targets distinct from cell cycle control. [J Clin Invest]

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SCIENCE NEWS

Soy May Stop Prostate Cancer Spread
Researchers have found that a new, nontoxic drug made from a chemical in soy could prevent the movement of cancer cells from the prostate to the rest of the body. [Press release from the Northwestern University Feinberg School of Medicine discussing data presented at the Ninth Annual American Association for Cancer Research Frontiers in Cancer Prevention Research Conference]

Prostate Cancer Clinical Stage Does Not Predict Recurrence
A new study challenges the current staging system that determines the extent or severity of prostate cancer that has not metastasized. [Press release from Wiley discussing online prepublication in Cancer]

New Function of Gene in Promoting Cancer Found by VCU Researchers
Researchers have discovered that a gene well known for its involvement in tumor cell development, growth and metastasis also protects cancer cells from being destroyed by chemotherapy. [Press release from Virginia Commonwealth University discussing online prepublication in Proceedings of the National Academy of Sciences USA]

Finding the ‘Fingerprints’ of Prostate Cancer
Researchers hope to make it easier for physicians to diagnose and gauge the severity of prostate cancer, which affects nearly one in five American men during their lifetime. They have identified genetic biomarkers of the disease that yield specific information about prostate tumors, permitting earlier detection and more effective treatment. [University of California, Irvine Press Release]

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LABORATORY RESEARCH

Astrocyte Elevated Gene-1 (AEG-1) Functions as an Oncogene and Regulates Angiogenesis
Researchers provide definitive evidence that astrocyte-elevated gene-1 (AEG-1) is indeed a transforming oncogene and show that stable expression of AEG-1 in normal immortal cloned rat embryo fibroblast cells induces morphological transformation and enhances invasion and anchorage-independent growth in soft agar, two fundamental biological events associated with cellular transformation. [Proc Natl Acad Sci USA]

CaM Kinase Kinase Beta-Mediated Activation of the Growth Regulatory Kinase AMPK is Required for Androgen-Dependent Migration of Prostate Cancer Cells
Using cellular models of prostate cancer, researchers have determined that androgens 1) directly increase the expression of a Ca2+/calmodulin-dependent protein kinase kinase beta (CaMKKbeta) splice variant and 2) increase functional CaMKKbeta protein levels as determined by the phosphorylation of both CaMKI and AMP-activated protein kinase, two of CaMKKbeta’s primary substrates. [Cancer Res]

A Novel Signaling Axis of Matriptase/PDGF-D/Beta-PDGFR in Human Prostate Cancer
Here, researchers identified platelet-derived growth factor (PDGF)-D as a ligand for beta-PDGF receptor in prostate cancer and discovered matriptase as its regulator. [Cancer Res]

p21(CIP-1/WAF-1) Induction Is Required to Inhibit Prostate Cancer Growth Elicited by Deficient Expression of the Wnt Inhibitor Dickkopf-1
In this study, researchers report that Dickkopf-1 knockdown in osteolytic human prostate cancer cells unexpectedly delays the development of both soft tissue and osseous lesions. [Cancer Res]

Photothermal Response of Human and Murine Cancer Cells to Multiwalled Carbon Nanotubes after Laser Irradiation
Human prostate cancer and murine renal carcinoma cells were irradiated with a 1,064-nm laser with an irradiance of 15.3 W/cm(2) for 2 heating durations (1.5 and 5 minutes) alone or in combination with multiwalled carbon nanotube inclusion. [Cancer Res]

PI3K Signaling Pathway is Activated by PIK3CA mRNA Overexpression and Copy Gain in Prostate Tumors, but PIK3CA, BRAF, KRAS and AKT1 Mutations are Infrequent Events
The phosphatidylinositol 3-kinase (PI3K)-AKT and RAS-MAPK pathways are deregulated in a wide range of human cancers by gain or loss of function in several of their components. The purpose of this study was to identify genetic alterations in members of these pathways in prostate cancer. [Mod Pathol]

PKCDelta Activation Mediates Angiogenesis via NADPH Oxidase Activity in PC-3 Prostate Cancer Cells
Here, researchers investigated the role of protein kinase C delta (PKCdelta) on the growth of PC-3 human prostate cancer cells in vivo and in vitro. [Prostate]

CLINICAL RESEARCH

Microfluidic Based Multiplex qRT-PCR Identifies Diagnostic and Prognostic microRNA Signatures in Sera of Prostate Cancer Patients
To identify serum miRNAs that diagnose and correlate with prognosis of prostate cancer, researchers developed a multiplex quantitative reverse transcription (qRT) PCR method involving purification of multiplex PCR products followed by uniplex analysis on a microfluidics chip to evaluate 384 human miRNAs. [Cancer Res]

Tumor Regression and Growth Rates Determined in Five Intramural NCI Prostate Cancer Trials – The Growth Rate as an Indicator of Therapeutic Efficacy
Researchers utilized a method estimating tumor growth and regression rate constants from serial PSA measurements, and assessed its potential in patients with metastatic castration resistant prostate cancer. [Clin Cancer Res]

Inaccuracies in Assignment of Clinical Stage for Localized Prostate Cancer
The findings further challenge the utility of a digital rectal examination-based and/or transrectal ultrasound-based staging system for risk assessment of localized prostate cancer. [Cancer]



INDUSTRY NEWS

Mentor Capital Cancer Immunotherapy Index Gains on Medicare Advisory Committee Approval of $93,000 Provenge Immunotherapy Treatment by Dendreon for Prostate Cancer
Mentor Capital, Inc. reports correlated gains across the 10 trading companies of the Mentor Capital Cancer Immunotherapy Index with the recent 6.6% one-day price appreciation of Index pioneer and market leader, Dendreon. [BusinessWire]





EVENTS (Listed by Date)

American Association for Cancer Research (AACR) Tumor Immunology – Basic and Clinical Advances
November 30-December 3, 2010
Miami, United States

5th Annual Stem Cell Meeting on the Mesa
December 7, 2010
La Jolla, United States

11th Annual Meeting of the Society of Urologic Oncology (SUO): Extraordinary Opportunities for Discovery
December 8-9, 2010
Bethesda, United States

The 3rd Guangzhou International Conference on Stem Cell Biology and Regenerative Medicine
December 17-19, 2010
Guangzhou, China

American Association for Cancer Research (AACR) Targeting PI3K/mTOR Signaling in Cancer
February 24-27, 2011
San Francisco, United States

American Association for Cancer Research (AACR) Stem Cells, Development, and Cancer
March 3-6, 2011
Vancouver, Canada

MENA Oncology Conference
March 11-12, 2011
Cairo, Egypt

The 6th International Conference on Oncolytic Viruses as Cancer Therapeutics
March 16-19, 2011
Las Vegas, United States

United Kingdom National Stem Cell Network 2011 Annual Scientific Conference
March 30-April 1, 2011
York, United Kingdom

American Association for Cancer Research (AACR) 102nd Annual Meeting 2011
April 2-6, 2011
Orlando, United States

International Society for Stem Cell Research (ISSCR) 9th Annual Meeting
June 15-18, 2011
Toronto, Canada

National Cancer Institute (NCI) Cancer Research Imaging Camp
June 19-24, 2011
St. Louis, United States

4th Annual Advances in Biodetection & Biosensors Conference and Exhibition
June 30-July 1, 2011
Hamburg, Germany

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.


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