Volume 1.42 | Nov 5

Prostate Cell News 1.42, November 5, 2010.
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events Subscribe  |  Unsubscribe

TOP STORY

Prostate Cancer’s Multiple Personalities Revealed 
The research team identified secondary mutations that cause some types of prostate cancer cells to be lethal. [Press release from the Weill Cornell Medical College discussing online prepublication in Genome Research]

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SCIENCE NEWS

Scientists Develop Method to Keep Surgically-Removed Prostate Tissue Alive
Scientists have developed a technique to keep normal and cancerous prostate tissue removed during surgery alive and functioning normally in the laboratory for up to a week. [Press release from Johns Hopkins Medicine discussing online prepublication in Cancer Research]

High-Dose, Short-Course Radiation for Prostate Cancer Does Not Increase Side Effects or Reduce Quality of Life
Researchers compared two groups of prostate cancer patients treated with intensity-modulated radiation therapy (IMRT). One group received conventional IMRT; the other group was treated with hypofractionated IMRT, which delivers a higher total dose of radiation in fewer sessions. [Press release from the Fox Chase Cancer Center discussing data presented at the 52nd Annual Meeting of the American Society for Radiation Oncology in San Diego]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

LABORATORY RESEARCH

Discovery of Non-ETS Gene Fusions in Human Prostate Cancer Using Next-Generation RNA Sequencing
Researchers used next-generation transcriptome sequencing in order to explore the whole transcriptome of 25 human prostate cancer samples for the presence of chimeric fusion transcripts. [Genome Res]

Human RecQL4 Helicase Plays Critical Roles in Prostate Carcinogenesis
Here, researchers report that human RecQL4 helicase, which is implicated in the pathogenesis of a subset of cancer-prone Rothmund-Thomson syndrome, is highly elevated in metastatic prostate cancer cell lines. [Cancer Res]

Class III Beta-Tubulin Expression Predicts Prostate Tumor Aggressiveness and Patient Response to Docetaxel-Based Chemotherapy
Here, researchers describe beta-III-tubulin immunohistochemical staining patterns of prostate tumors obtained from a broad spectrum of prostate cancer (PCa) patients, some of whom subsequently received docetaxel therapy for castration-resistant Pca. [Cancer Res]

Dysregulation of the Mitogen Granulin in Human Cancer Through the miR-15/107 microRNA Gene Group
In this study, researchers queried whether miR-107 and paralogs regulated granulin in human cancers. [Cancer Res]

Knockdown of Inwardly Rectifying Potassium Channel Kir2.2 Suppresses Tumorigenesis by Inducing Reactive Oxygen Species-Mediated Cellular Senescence
Senescence is an important determinant of treatment outcome in cancer therapy. In the present study, researchers show that knockdown of the inwardly rectifying K+ channel Kir2.2 induced growth arrest without additional cellular stress in cancer cells lacking functional p53, p16, and/or Rb. [Mol Cancer Ther]

HOXC8 Inhibits Androgen Receptor Signaling in Human Prostate Cancer Cells by Inhibiting SRC-3 Recruitment to Direct Androgen Target Genes
In the present study, researchers show that HOXC8 inhibits androgen receptor (AR)-mediated gene induction in LNCaP prostate cancer cells and HPr-1 AR, a non-tumorigenic prostate epithelial cell. [Mol Cancer Res]

Comorbidity and Mortality Results From a Randomized Prostate Cancer Screening Trial
Selective use of prostate-specific antigen screening for men in good health appears to reduce the risk of prostate cancer-specific mortality with minimal overtreatment. [J Clin Oncol]

Impact of Androgen-Deprivation Therapy on Cognitive Function in Men With Nonmetastatic Prostate Cancer
The purpose of this study was to evaluate the effects of androgen-deprivation therapy on cognitive function in men with nonmetastatic prostate cancer. [J Clin Oncol]

Impact of Androgen Deprivation Therapy on Physical Function and Quality of Life in Men With Non-Metastatic Prostate Cancer
This prospective longitudinal study evaluated the effect of androgen deprivation therapy on objective and self-reported physical function. [J Clin Oncol]



INDUSTRY NEWS

EACH and ICER Launch Prostate Cancer Decision Aid Website
The Employers Action Coalition on Healthcare (EACH), a group of employers, providers and health plans in Massachusetts, in conjunction with the Institute for Clinical and Economic Review (ICER), part of the Massachusetts General Hospital’s Institute for Technology Assessment, are launching a new website for patients recently diagnosed with low-risk prostate cancer. [The Institute for Clinical and Economic Review Press Release]

Millennium and Takeda Announce Advancement of Prostate Cancer Program
Millennium: The Takeda Oncology Company with its parent company Takeda Pharmaceutical Company Limited announced the initiation of a Phase III clinical trial for TAK-700 in the U.S. in patients with advanced prostate cancer. [Millennium: The Takeda Oncology Company Press Release]



POLICY NEWS

U.S. Says Genes Should Not Be Eligible for Patents
Reversing a longstanding policy, the federal government said on Friday that human and other genes should not be eligible for patents because they are part of nature. The new position could have a huge impact on medicine and on the biotechnology industry. [Department of Justice, United States]

NIH Introduces Images, a Database of Images in Biomedical Literature
More than 2.5 million images and figures from medical and life sciences journals are now available through Images, a new resource for finding images in biomedical literature. [National Institutes of Health, United States]

NIH Recovery Act Grants to Foster Scientific Workforce Diversity
The National Institutes of Health has awarded six grants totaling approximately $12 million over three years through a new initiative aimed at fostering a diverse scientific workforce. [National Institutes of Health, United States]

Guidelines for Use of Stored Specimens and Access to Ancillary Data and Proposed Cost Schedule: Stored Biologic Specimens and Ancillary Data From the Collaborative Perinatal Project (CPP) (FR Doc. 2010-27183) [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meeting (FR Doc. 2010-27325) [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-27185) [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-27192) [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meeting (FR Doc. 2010-27039) [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meeting (FR Doc. 2010-27040) [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-27049) [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-26881) [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meeting (FR Doc. 2010-26935) [National Institutes of Health, United States]

National Cancer Institute; Notice of Closed Meeting (FR Doc. 2010-27410) [National Institutes of Health, United States]

Office of the Director, National Institutes of Health; Notice of Meeting (FR Doc. 2010-27187) [National Institutes of Health, United States]



EVENTS (Listed by Date)

National Cancer Research Institute (NCRI) Conference 2010
November 7-10, 2010
Liverpool, United Kingdom

9th Annual American Association for Cancer Research (AACR) International Conference: Frontiers in Cancer Prevention Research
November 7-10, 2010
Philadelphia, United States

22nd European Organization for Research and Treatment of Cancer (EORTC)-National Cancer Institute (NCI)-American Association for Cancer Research (AACR) Symposium: Molecular Targets and Cancer Therapeutics
November 16-19, 2010
Berlin, Germany

Cancer Pharmacogenetics: Personalizing Medicine
November 22-24, 2010
Madrid, Spain

American Association for Cancer Research (AACR) Tumor Immunology – Basic and Clinical Advances
November 30-December 3, 2010
Miami, United States

5th Annual Stem Cell Meeting on the Mesa
December 7, 2010
La Jolla, United States

11th Annual Meeting of the Society of Urologic Oncology (SUO): Extraordinary Opportunities for Discovery
December 8-9, 2010
Bethesda, United States

American Association for Cancer Research (AACR) Targeting PI3K/mTOR Signaling in Cancer
February 24-27, 2011
San Francisco, United States

American Association for Cancer Research (AACR) Stem Cells, Development, and Cancer
March 3-6, 2011
Vancouver, Canada

MENA Oncology Conference
March 11-12, 2011
Cairo, Egypt

The 6th International Conference on Oncolytic Viruses as Cancer Therapeutics
March 16-19, 2011
Las Vegas, United States

United Kingdom National Stem Cell Network 2011 Annual Scientific Conference
March 30-April 1, 2011
York, United Kingdom

American Association for Cancer Research (AACR) 102nd Annual Meeting 2011
April 2-6, 2011
Orlando, United States

International Society for Stem Cell Research (ISSCR) 9th Annual Meeting
June 15-18, 2011
Toronto, Canada

National Cancer Institute (NCI) Cancer Research Imaging Camp
June 19-24, 2011
St. Louis, United States

4th Annual Advances in Biodetection & Biosensors Conference and Exhibition
June 30-July 1, 2011
Hamburg, Germany

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.


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