Volume 1.25 | Jul 9

Prostate Cell News 1.25, July 9, 2010.
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events Subscribe  |  Unsubscribe

TOP STORY

Androgen-Induced TOP2B-Mediated Double-Strand Breaks and Prostate Cancer Gene Rearrangements  
Researchers show that androgen signaling promotes co-recruitment of androgen receptor and topoisomerase II beta (TOP2B) to sites of TMPRSS2-ERG genomic breakpoints, triggering recombinogenic TOP2B-mediated DNA double-strand breaks. [Nat Genet]

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SCIENCE NEWS

UNC Team Finds New Target for Treatment of Advanced Prostate Cancer
A recent study provides evidence for a theory demonstrating that expression of one of a group of genes found only in humans and non-human primates can promote androgen receptor activity in concert with coregulators. [Press release from the UNC School of Medicine discussing online prepublication in Journal of Biological Chemistry]

Baseline PSA Predicts Risk of Death from Prostate Cancer
Men who have a baseline PSA value of 10 or higher the first time they are tested are up to 11 times more likely to die from prostate cancer than men with lower initial values, according to researchers. [Press release from the Duke University Health System discussing online prepublication in Cancer]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

LABORATORY RESEARCH

Protein Tyrosine Kinase 6 Directly Phosphorylates AKT and Promotes AKT Activation in Response to Epidermal Growth Factor
Here, researchers demonstrate that AKT is a direct substrate of PTK6, and that AKT tyrosine residues 315 and 326 are phosphorylated by PTK6. [Mol Cell Biol]

Purinergic Receptor-Mediated Rapid Depletion of Nuclear pAkt Depends on PH Domain Leucine-Rich Repeat Phosphatase (PHLPP), Calcineurin, PP2A and PTEN Phosphatases
Researchers have previously described a rapid and P2X7-dependent depletion of nuclear phosphorylated Akt (pAkt) and effects on downstream targets. Here, they studied mechanisms behind the pAkt depletion. [J Biol Chem]

Fkbp52 Regulates Androgen Receptor Transactivation Activity and Male Urethra Morphogenesis
Taken together, the data show FK506-binding protein-52 (Fkbp52) to be an important molecular regulator in the androgen-mediated pathway of urethra morphogenesis. [J Biol Chem]

Baseline PSA as a Predictor of Prostate Cancer-Specific Mortality Over the Past 2 Decades
A diagnosis of prostate cancer is not often predictive of death from prostate cancer because of competing causes of mortality. Identification of the risk of death from prostate cancer and death from all causes using information available at the time of baseline prostate-specific antigen (PSA) measurement appears to be particularly pertinent. [Cancer]

Association of Core Binding Factor with the Malignant Phenotype of Prostate and Ovarian Cancer Cells
To test whether Core Binding Factor (CBF) is required for the malignant phenotype of various epithelial cancers, researchers used lentiviral delivery of CBF-beta specific shRNA to significantly decrease CBF-beta expression in two prostate cancer cell lines (PPC1 and PC-3) and the SKOV-3 ovarian cancer cell line. [J Cell Physiol]

p53 Downregulates the Gene Expression of Mitochondrial Aconitase in Human Prostate Carcinoma Cells
Researchers investigated whether p53 regulates mitochondrial aconitase (mACON) expression and explore the potential mechanisms responsible for its effect on prostate cancer cells. [Prostate]

Liposomal Imatinib-Mitoxantrone Combination: Formulation Development and Therapeutic Evaluation in an Animal Model of Prostate Cancer
The loading parameters and drug retention properties of the liposomal imatinib-mitoxantrone formulation, combined with its in vivo antitumor activity, make this formulation an excellent strategy to improve the therapeutic index of mitoxantrone and a promising candidate for clinical development in prostate cancer therapy. [Prostate]

Role of Monocyte-Lineage Cells in Prostate Cancer Cell Invasion and Tissue Factor Expression
Tissue factor (TF) is a cell surface glycoprotein intricately related to blood coagulation and inflammation. This study was performed to investigate the role of monocyte-lineage cells in prostate cancer cell TF expression and cell invasion. [Prostate]

CLINICAL RESEARCH

Mortality Results From the Göteborg Randomised Population-Based Prostate-Cancer Screening Trial
Prostate cancer is one of the leading causes of death from malignant disease among men in the developed world. One strategy to decrease the risk of death from this disease is screening with prostate-specific antigen (PSA); however, the extent of benefit and harm with such screening is under continuous debate. [Lancet Oncol]

Radionuclide and Hybrid Imaging of Recurrent Prostate Cancer
Here, researchers review the contribution of radionuclide imaging and hybrid imaging for assessment of recurrent prostate cancer (local vs regional vs distant disease). [Lancet Oncol]

INDUSTRY NEWS

Claros Diagnostics Receives CE Mark Approval for Point-of-Care PSA System
Claros Diagnostics announced the CE Mark approval for its rapid quantitative point-of-care diagnostic platform, which can now be used for prostate specific antigen (PSA) testing throughout the European Union. [Claros Diagnostics Press Release]



POLICY NEWS

Research Budgets Face Austerity in 2012
The National Institutes of Health and other life sciences and biomedical research funding agencies will need to trim their budgets for 2012, which are to be planned over the summer, to satisfy a White House that is now stressing deficit reduction and belt-tightening after two years of stimulus funding-boosted research budgets. [The Office of Management and Budget, United States]

The Reality of Human Stem Cell Research in Europe
A new report from the European Science Foundation examines the key scientific questions for human stem cell research in the context of the rapidly emerging field of regenerative medicine. [European Science Foundation, European Union]

Strong Medicine for French Research
The medical-research adviser to France’s president aims to shift power and money to universities. [National Research Agency, France]

Meeting of the National Advisory Council for Healthcare Research and Quality [Agency for Healthcare Research and Quality, United States]

Maryland Stem Cell Research Commission – Public Meeting Notice [Maryland Stem Cell Research Commission, United States]

Center for Scientific Review; Notice of Closed Meetings [National Institutes of Health, United States]

Science Board Advisory Committee; Notice of Meeting (Docket No. FDA-2010-N-0001) [Food and Drug Administration, United States]

Guidance for Industry: Adaptive Design Clinical Trials for Drugs and Biologics [Food and Drug Administration, United States]

Medical Devices; Availability of Safety and Effectiveness Summaries for Premarket Approval Applications (Docket Nos. FDA-2010-M-0068, FDA-2010-M-0078, FDA-2010-M-0063, FDA-2010-M-0135, FDA-2010-M-0158) [Food and Drug Administration, United States]



EVENTS

Translational Cancer Medicine 2010 – USA
July 11-14, 2010
San Francisco, United States

United Kingdom National Stem Cell Network (UKNSCN) Third Annual Scientific Conference
July 12-14, 2010
Nottingham, United Kingdom

2nd International Conference on Cellular and Molecular Bioengineering (ICCMB2)
August 2-4, 2010
Singapore City, Singapore

CHI’s 5th Annual Immunotherapeutics and Vaccine Summit (ImVacS)
August 17-19, 2010
Cambridge, United States

2010 World Cancer Congress
August 18-21, 2010
Shenzhen, China

Joint Annual Meeting of the International Continence Society (ICS) and International Urogynecological Association (IUGA)
August 23-27, 2010
Toronto, Canada

Select Biosciences 3rd Annual Stem Cells Europe Conference
August 24-25, 2010
Edinburgh, Scotland

Select Biosciences 2nd Annual World Biobanking Summit
August 24-25, 2010
Edinburgh, Scotland

Select Biosciences Inaugural Cellular Therapy Summit
August 24-25, 2010
Edinburgh, Scotland

28th World Congress of Endourology and SWL
September 1-4, 2010
Chicago, United States

International Society for Cellular Therapy (ISCT) – Europe 2nd Regional Meeting
September 11-14, 2010
Belgirate, Italy

35th European Society for Medical Oncology (ESMO) Congress
October 8–12, 2010
Milan, Italy

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.



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