Volume 1.12 | Apr 9

Prostate Cell News 1.12, April 9, 2010.
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events Subscribe  |  Unsubscribe

TOP STORY

Anti-HIV Drugs Inhibit Emerging Virus Linked to Prostate Cancer, Chronic Fatigue Syndrome
The findings suggest that if XMRV (xenotropic murine leukemia virus-related virus) is proven to be a cause for prostate cancer or chronic fatigue syndrome, those illnesses may be treatable with drugs already approved for treating HIV. [Press release from Emory University discussing the online prepublication in PLoS ONE]

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SCIENCE NEWS

Drug Reduces Risk of Prostate Cancer Diagnosis in High-Risk Men
A drug already prescribed to shrink benign, enlarged prostates has been shown to reduce the risk of a prostate cancer diagnosis by 23 percent in men with an increased risk of the disease, a large international trial has found. [Press release from Washington University in St. Louis discussing the online prepublication in New England Journal of Medicine]

Study Suggests that Tocotrienol has a Common Cancer-Killing Mechanism for Different Cancer Types
Researchers have shown that gamma-tocotrienol, a member of the vitamin E family, is potent in killing prostate tumour cells in animal model studies. [Press release from PR Newswire discussing the online prepublication in Pharmacology]

New Method to Study Key Targets in Alzheimer’s Disease and Prostate Cancer
Researchers have developed a method to obtain structural information about intrinsically disordered proteins. Using this methodology, they will address the androgen receptor, the target protein in prostate cancer. [Press release from Institute for Research in Biomedicine Barcelona discussing online prepublication in Journal of the American Chemical Society]

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CURRENT PUBLICATIONS

LABORATORY RESEARCH

Metallofullerene Nanoparticles Circumvent Tumor Resistance to Cisplatin by Reactivating Endocytosis
The results suggest that [[email protected]82(OH)22]n nanoparticles overcome tumor resistance to cisplatin by increasing its intracellular accumulation through the mechanism of restoring defective endocytosis. [Proc Natl Acad Sci U S A]

p66Shc is Indispensable for Phenethyl Isothiocyanate-Induced Apoptosis in Human Prostate Cancer Cells
Collectively, these results provide novel insight into the critical role of p66Shc in regulation of phenethyl isothiocyanate-induced apoptotic cell death in human prostate cancer cells. [Cancer Res]

The Synthetic Estrogen Diethylstilbestrol (DES) Inhibits the Telomerase Activity and Gene Expression of Prostate Cancer Cells
Researchers investigated in vitro the effect of synthetic estrogen diethylstilbestrol on telomerase activity and on gene expression in the presence and absence of androgens. [Prostate]

Ozarelix, a Fourth Generation GnRH Antagonist, Induces Apoptosis in Hormone Refractory Androgen Receptor Negative Prostate Cancer Cells Modulating Expression and Activity of Death Receptors
This study explored the in vitro effects on DU145 and PC3 cell lines, two models of androgen-independent prostate cancer, of a fourth generation GnRH antagonist (Ozarelix). [Prostate]

In Vivo Evidence of Gamma-Tocotrienol as a Chemosensitizer in the Treatment of Hormone-Refractory Prostate Cancer
In the present study, the pharmacokinetics of GammaT3 and the in vivo cytotoxic response of androgen-independent prostate cancer tumor following GammaT3 treatment were investigated. [Pharmacology]

Raltegravir Is a Potent Inhibitor of XMRV, a Virus Implicated in Prostate Cancer and Chronic Fatigue Syndrome

Researchers found that the retroviral integrase inhibitor, raltegravir, was potent and selective against xenotropic murine leukemia-related retrovirus at submicromolar concentrations, in MCF-7 and LNCaP cells, a breast cancer and prostate cancer cell line, respectively. [PLoS ONE]

CLINICAL RESEARCH

Effect of Dutasteride on the Risk of Prostate Cancer
Researchers conducted a study to determine whether dutasteride reduces the risk of incident prostate cancer, as detected on biopsy, among men who are at increased risk for the disease. [N Engl J Med]

Is Urine Culture Routinely Necessary Before Prostate Biopsy?
These results suggest that routine urine bacterial culture before prostate biopsy is not useful when antibiotic prophylaxis and enema are performed. [Prostate Cancer Prostatic Dis]


INDUSTRY NEWS

US Seeks to Make Science Free For All
Moves to make research funded by the US government available to everyone could mark a turning point in a publishing revolution. [Nature News]

CytRx to Initiate a Phase II Clinical Trial with Bafetinib in Advanced Prostate Cancer
CytRx Corporation announced plans to initiate a Phase II proof-of-concept clinical trial in the second half of 2010 to evaluate the effectiveness and safety of its oncology drug candidate bafetinib in patients with an advanced form of prostate cancer known as metastatic hormone-refractory prostate cancer. [CytRx Corporation Press Release]

Market Watch: Key Clinical and Regulatory Events in Q2 2010
A US FDA decision on the possible approval of potentially the first therapeutic cancer vaccine – sipuleucel-T (Provenge; developed by Dendreon) for castration-resistant metastatic prostate cancer – is expected by 1 May. [Nature Reviews]


POLICY NEWS

Enhancing Peer Review: Updated Processes for the Review of All Ruth L. Kirschstein National Research Service Award Fellowship Applications (NOT-OD-10-071) [National Institutes of Health, United States]

NIH Will Require the Electronic Submission of Appointment Forms and Termination Notices Via xTrain for Research Training, Fellowship, Education, and Career Awards Beginning January 2011 (NOT-OD-10-072) [National Institutes of Health, United States]

Small Business Innovation Research Award Levels Adjusted to $150,000 (Phase I) and $1,000,000 (Phase II) (NOT-OD-10-079) [National Institutes of Health, United States]

Notice of Change in Expiration Date for Program Announcement on Bioengineering Research Partnerships (PAR-07-352) (NOT-EB-10-001) [National Institutes of Health, United States]

Revision of the Requirements for Constituent Materials (Docket No. FDA-2010-N-0099) [Food and Drug Administration, United States]

Voting and Nonvoting Consumer Representative Members on Public Advisory Committees and Panels; Notice of Public Meeting (Docket No. FDA-2010-N-0001) [Food and Drug Administration, United States]

Determination of Regulatory Review Period for Purposes of Patent Extension; LUSEDRA (Docket Nos. FDA-2009-E-0202 and FDA-2009-E-0204) [Food and Drug Administration, United States]

Revision of Organization and Conforming Changes to Regulations (Docket No. FDA-2010-N-0148) [Food and Drug Administration, United States]

Administrative Practices and Procedures; Good Guidance Practices; Technical Amendment (Docket No. FDA-1999-N-3539) [Food and Drug Administration, United States]

2010 Biological License Application Supplement Noteworthy Approvals [Food and Drug Administration, United States]


EVENTS

American Association for Cancer Research (AACR) 101st Annual Meeting
April 17-21, 2010
Washington, DC, United States

American Urological Association (AUA) 2010 Annual Meeting
May 29-June 3, 2010
San Francisco, United States

International Society for Stem Cell Research (ISSCR) 8th Annual Meeting
June 16-19, 2010
San Francisco, United States

21st Meeting of the European Association for Cancer Research (EACR) 
June 26-29, 2010
Oslo, Norway

United Kingdom National Stem Cell Network (UKNSCN) Third Annual Scientific Conference
July 12-14, 2010
Nottingham, United Kingdom

2010 World Cancer Congress
August 18-21, 2010
Shenzhen, China

Joint Annual Meeting of the International Continence Society (ICS) and International Urogynecological Association (IUGA)
August 23-27, 2010
Toronto, Canada

28th World Congress of Endourology and SWL
September 1-4, 2010
Chicago, United States

35th European Society for Medical Oncology (ESMO) Congress
October 8-12, 2010
Milan, Italy

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.

 

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