Volume 1.11 | Mar 26

Prostate Cell News 1.11, March 26, 2010.
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Infertility Raises Risk of More Aggressive Prostate Cancer
Infertility increases the risk that a man will develop the aggressive, potentially fatal form of prostate cancer, a new study suggests. [Press release from BusinessWeek discussing online prepublication in Cancer]

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Walnuts Could Prevent Prostate Cancer, Research Finds
Researchers found that mice which were fed on walnuts developed prostate cancers around 50 per cent smaller than a control group which were given soya bean oil instead. [Telegraph Press Release]

Caltech-Led Team Provides Proof in Humans of RNA Interference Using Targeted Nanoparticles
A California Institute of Technology (Caltech)-led team of researchers and clinicians has published the first proof that a targeted nanoparticle, used as an experimental therapeutic and injected directly into a patient’s bloodstream, can traffic into tumors, deliver double-stranded small interfering RNAs, and turn off an important cancer gene using RNA interference. [Press release from The California Institute of Technology discussing online prepublication in Nature]

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Evidence of RNAi in Humans from Systemically Administered siRNA via Targeted Nanoparticles
Data demonstrate that siRNA administered systemically to a human can produce a specific gene inhibition (reduction in mRNA and protein) by an RNAi mechanism of action. [Nature]

Regulation of Minichromosome Maintenance Gene Family by MicroRNA-1296 and Genistein in Prostate Cancer
Here, researchers examined the role of MCM2 in prostate cancer and the effect of microRNA-1296, genistein, and trichostatin A on the MCM complex. [Cancer Res]

MicroRNA-145 Targets BNIP3 and Suppresses Prostate Cancer Progression
Although BNIP3 transcription is controlled by hypoxia-inducible factor 1(alpha) (also elevated in prostate cancer), researchers postulated the posttranscriptional regulation of BNIP3 by miR145 through bioinformatics analysis, and herein researchers experimentally showed that miR145 negatively regulated BNIP3 by targeting its 3′-untranslated region. [Cancer Res]

Isolation, Cultivation and Characterization of Adult Murine Prostate Stem Cells
Here, researchers describe step-by-step procedures on the basis of previous work in their laboratory for the harvesting of primary prostate cells from adolescent male mice by a modified enzymatic procedure; the isolation of an enriched population of prostate stem cells through cell sorting; and the cultivation of prostate stem cells in vitro and characterization of these cells and their stem-like activity, including in vivo tubule regeneration. [Nat Protoc]

Phorbol Ester Phorbol-12-Myristate-13-Acetate Induces Epithelial to Mesenchymal Transition in Human Prostate Cancer ARCaP(E) Cells
Researchers have reported that human prostate cancer ARCaP(E) cells undertake epithelial to mesenchymal transition (EMT) when stimulated by certain soluble factors, and that EMT is regulated by surface receptor-elicited signaling pathways through protein phosphorylation. [Prostate]

5-Azacitidine Restores and Amplifies the Bicalutamide Response on Preclinical Models of Androgen Receptor Expressing or Deficient Prostate Tumors
This study tested the hypothesis that 5-Azacitine may restore and enhance the responsiveness of hormone refractory prostate cancer cells to anti-hormonal therapy on androgen receptor (AR)-expressing (22rv1) and AR-deficient (PC3) cells. [Prostate]

Modeling the Prostate Stem Cell Niche: An Evaluation of Stem Cell Survival and Expansion In Vitro
The goal of this work was to engineer a clinically relevant in vitro model of human prostate stem cells that could be used to interrogate the mechanisms of stem cell control. [Stem Cells Dev]

Molecular Signatures of Prostate Stem Cells Reveal Novel Signaling Pathways and Provide Insights into Prostate Cancer
The global gene expression profiles of adult and fetal murine prostate stem cells were determined to define common and unique regulators whose misexpression might play a role in the development of prostate cancer. [PLoS ONE]


Increased Risk of High-Grade Prostate Cancer Among Infertile Men
Men with male factor infertility were found to have an increased risk of subsequently developing high-grade prostate cancer. Male infertility may be an early and identifiable risk factor for the development of clinically significant prostate cancer. [Cancer]

Prostate Cancer-Specific Mortality and the Extent of Therapy in Healthy Elderly Men with High-Risk Prostate Cancer
The risk of prostate cancer-specific mortality in healthy elderly men may depend on extent of treatment. The authors of this report compared the use of brachytherapy alone with combined brachytherapy, external-beam radiation to the prostate and seminal vesicles, and androgen-suppression therapy in this population. [Cancer]

Impact of Recent Screening on Predicting the Outcome of Prostate Cancer Biopsy in Men With Elevated Prostate-Specific Antigen
Risk models to predict prostate cancer on biopsy, whether they include only prostate-specific antigen (PSA) or other markers, are intended for use in all men of screening age. However, the association between PSA and cancer probably depends on a man’s recent screening history. [Cancer]


GTx and Ipsen Expand Partnership
Ipsen and GTx, Inc. announced the expansion of their partnership for the development and commercialization of toremifene (80 mg) for the reduction of fractures in men with advanced prostate cancer on androgen deprivation therapy (ADT) and toremifene (20 mg) for the prevention of prostate cancer in high risk patients with high grade prostatic intraepithelial neoplasia lesions. [GTx, Inc., Press Release]


It’s The Law of The Land: Health Overhaul Signed
Claiming a historic triumph that could define his presidency, a jubilant Barack Obama signed a massive, nearly $1 trillion health care overhaul that will for the first time cement insurance coverage as the right of every U.S. citizen and begin to reshape the way virtually all Americans receive and pay for treatment. [The White House, United States]

HHS Announces Additional $162 Million in Recovery Act Investment to Advance Widespread Meaningful Use of Health IT
U.S. Department of Health and Human Services (HHS) Secretary Kathleen Sebelius announced awards to help states facilitate health information exchange and advance health information technology (Health IT). [The Department of Health and Human Services, United States]

Instructions for Completion and Peer Review of the Vertebrate Animal Section in NIH Grant Applications and Cooperative Agreements (NOT-OD-10-027) [National Institutes of Health, United States]

Recovery Act: Update on American Recovery and Reinvestment Act Quarterly Reporting Requirements for Non-Competing Continuation Awards and Relinquished Projects; and Guidance to Avoid Common Errors (NOT-OD-10-065)
[National Institutes of Health, United States]

Recovery Act: Reminders on Annual Reporting Requirements and Notice of Revised Financial Closeout Requirements for American Recovery and Reinvestment Act-Funded Administrative Supplements and Competitive Revisions (NOT-OD-10-066) [National Institutes of Health, United States]

Recovery Act: Notice on the Proper Management of Recovery Act Spending to Promote Job Creation and Increase the Pace of Scientific Research; and Policy Limiting Second No-Cost Extensions to Recovery Act Grants (NOT-OD-10-067)
[National Institutes of Health, United States]

Request for Comments on Proposed NIH, Agency for Healthcare Research and Quality and Center of Disease Control Process Change for Electronic Submission of Grant Applications (NOT-OD-10-068) [National Institutes of Health, United States]

Amended NIH Policy on Submission of Late Grant Application Materials Prior to Initial Peer Review (NOT-OD-10-070) [National Institutes of Health, United States]

Modification: This Notice modifies RFA-RM-10-001 (NOT-RM-10-005) [National Institutes of Health, United States]

Modification to RFA-RM-09-019: Institutional Clinical and Translational Science Award (U54) (NOT-RM-10-006) [National Institutes of Health, United States]


American Association for Cancer Research (AACR) 101st Annual Meeting
April 17-21, 2010
Washington, DC, United States

American Urological Association (AUA) 2010 Annual Meeting
May 29-June 3, 2010
San Francisco, United States

International Society for Stem Cell Research (ISSCR) 8th Annual Meeting
June 16-19, 2010
San Francisco, United States

21st Meeting of the European Association for Cancer Research (EACR) 
June 26-29, 2010
Oslo, Norway

United Kingdom National Stem Cell Network (UKNSCN) Third Annual Scientific Conference
July 12-14, 2010
Nottingham, United Kingdom

2010 World Cancer Congress
August 18-21, 2010
Shenzhen, China

Joint Annual Meeting of the International Continence Society (ICS) and International Urogynecological Association (IUGA)
August 23-27, 2010
Toronto, Canada

28th World Congress of Endourology and SWL
September 1-4, 2010
Chicago, United States

35th European Society for Medical Oncology (ESMO) Congress
October 8-12, 2010
Milan, Italy

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.



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