Volume 1.08 | Mar 5

Prostate Cell News 1.08, March 5, 2010.
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events Subscribe  |  Unsubscribe

TOP STORY

Role of Multi-hnRNP Nuclear Complex in Regulation of Tumor Suppressor ANXA7 in Prostate Cancer Cells
In this study, researchers studied Annexin-A7 (ANXA7) regulation in normal prostate versus androgen-sensitive and -resistant prostate cancer cells. [Oncogene]

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SCIENCE NEWS

Drug May Work on Advanced Prostate Cancer
For the first time, an experimental drug has extended the lives of men with advanced prostate cancer who are no longer responding to other treatments and are out of options for fighting the disease, a company-led study found. [CBS News Press Release]

ASCO Genitourinary Cancers Symposium: Novel Urine Test IDs Prostate Cancer
The Prostate Cancer Gene 3 (PCA3) test score at the time of a negative first biopsy predicted a positive rebiopsy two years later with 79.1% specificity and 36.4% sensitivity. [MedPage Today Press Release]

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CURRENT PUBLICATIONS

LABORATORY RESEARCH

Liver X Receptor Activation Downregulates AKT Survival Signaling in Lipid Rafts and Induces Apoptosis of Prostate Cancer Cells
Pharmacological modulation of liver X receptors activity could reduce prostate tumor growth by enhancing apoptosis in a lipid raft-dependent manner. [Oncogene]

Mutant p53 Initiates a Feedback Loop that Involves Egr-1/EGF Receptor/ERK in Prostate Cancer Cells
Mutant p53 initiates a feedback loop that involves ERK1/2-mediated transactivation of Egr-1, which in turn increases the secretion of EGFR ligands and stimulates the EGFR signaling pathway. [Oncogene]

Pooled Analysis of Phosphatidylinositol 3-Kinase Pathway Variants and Risk of Prostate Cancer
Researchers observed a significant association between PIK3C2B and prostate cancer risk, especially for familial, early-onset disease, which may be attributable to insulin-like growth factor-dependent phosphatidylinositol 3-kinase signaling. [Cancer Res]

Hsp27 Promotes Insulin-Like Growth Factor-I Survival Signaling in Prostate Cancer via p90Rsk-Dependent Phosphorylation and Inactivation of BAD
Here, researchers report that Hsp27 expression and phosphorylation levels correlate with insulin-like growth factor-I signaling and castrate-resistant progression in human prostate cancer specimens and cell lines. [Cancer Res]

Downregulation of BiP/GRP78 Sensitizes Resistant Prostate Cancer Cells to Gene-Therapeutic Overexpression of REIC/Dkk-3
The aim of the present study was to determine the molecular mechanisms of resistance to an adenovirus carrying REIC/Dkk-3. [Int J Cancer]

The 4q27 Locus and Familial Prostate Cancer Risk
Researchers investigate a potential association between variants in an autoimmune related region on chromosome 4q27 and prostate cancer risk. This region harbors two cytokine genes, IL-2 and the recently described IL-21. [BMC Cancer]

Inhibition of DHCR24/Seladin-1 Impairs Cellular Homeostasis in Prostate Cancer
The present study aims to investigate the localization and expression of Seladin-1 protein in normal and tumoral human prostatic tissues as well as to explore its role in proliferation and steroid secretion in androgen-dependent (LNCaP) and androgen-independent (DU145) cell lines and in human prostate primary cell culture. [Prostate]

Snail Transcription Factor Regulates Neuroendocrine Differentiation in LNCaP Prostate Cancer Cells
Data provide evidence that Snail transcription factor may promote tumor aggressiveness in the LNCaP cells through multiple processes; induction of epithelial-mesenchymal transition may be required to promote migration, while neuroendocrine differentiation may promote tumor proliferation by a paracrine mechanism. [Prostate]

CLINICAL RESEARCH

Value of Magnetic Resonance Spectroscopy Imaging and Dynamic Contrast-Enhanced Imaging for Detecting Prostate Cancer Foci in Men With Prior Negative Biopsy
The combination of magnetic resonance spectroscopy imaging and dynamic-contrast enhancement magnetic resonance showed the potential to guide biopsy to cancer foci in patients with previously negative trans-rectal ultrasound biopsy. [Clin Cancer Res]

Prospective Comparison of PSA Kinetics Following Two Different Prostate Cancer Brachytherapy Planning Methods: Preoperative and Real-Time Intraoperative Dosimetry Planning
Preoperative planning and intraoperative planning are established 125I-brachytherapy techniques for the treatment of localized prostate cancer. Researchers prospectively compared the effects of each method on reducing PSA levels. [Urol Oncol]

The Influence of Hepatic Function on Prostate Cancer Outcomes After Radical Prostatectomy
Mild hepatic dysfunction was significantly associated with adverse prostate cancer grade, but was not significantly associated with other adverse pathological features or biochemical recurrence in a cohort of men undergoing radical prostatectomy. [Prostate Cancer Prostatic Dis]


INDUSTRY NEWS

Cabazitaxel Increased Survival for Patients with Advanced Hormone-Refractory Prostate Cancer
Sanofi-aventis announced results from a Phase III trial which demonstrated cabazitaxel, an investigational compound, plus prednisone/prednisolone significantly improved overall survival and progression-free survival in patients with metastatic hormone-refractory prostate cancer whose disease progressed following treatment with docetaxel-based chemotherapy. [Sanofi-aventis Press Release]

Molecular Targeting Technologies, Inc. Licenses Cell Targeting Technology from the University of Notre Dame
Molecular Targeting Technologies, Inc., announced that it has obtained an exclusive license from the University of Notre Dame for novel sensing technology developed by Professor Bradley Smith. [Molecular Targeting Technologies Press Release]


POLICY NEWS

Canadian Budget Light on New Research Dollars
Relief was the order of the day for Canadian scientists on Thursday as the federal government brought down its fiscal blueprint for 2010-11. Finance Minister Jim Flaherty moved to partially offset scheduled cuts in the budgets of the nation’s three granting councils, though they’ll still take a blow and there’ll be tighter competition for research operating grants. [Science]

Study Finds Stem Cell Research in the State of Maryland Supports More than 500 Local Jobs and Facilitates $71.3 Million in Business Sales Annually
A recent third party economic development impact study conducted by Sage Policy Group, Inc., entitled “Economic Benefits of Maryland’s Stem Cell Program Already Apparent,” found that Maryland’s Stem Cell Research Fund supports 514 local jobs, with an average salary of $64,000, and facilitates $71.3 million in business sales in the state. [Maryland Stem Cell Research Fund, United States]

Idaho Senate Votes 21-13 for ‘Conscience’ Bill
After a long and emotional debate, Senators voted 21-13 to allow pharmacists, nurses and other health-care workers to opt out of providing assistance for abortions, stem cell therapy, emergency contraception or end-of-life care, if they first tell their employers the procedures violate their conscience. [Idaho Senate, United States]

Indian Council of Medical Research to Set Up Apex Committee to Regulate Stem Cell Research
Indian Council of Medical Research said recently it would soon set up a body to regulate the scientific community on the crucial health research of stem cell therapy. [Indian Council of Medical Research, India]

Suit Possible Over Baby DNA Sent to Military Lab for National Database
An Austin lawyer threatened to pursue a new federal lawsuit after learning that some newborn blood samples in Texas went to the U.S. military for potential use in a database for law enforcement purposes. [The Statesman, United States]

2010 Biological License Application Approvals [Food and Drug Administration, United States]

2009 Biological New Drug Application (NDA) and Abbreviated New Drug Application (ANDA) Approvals [Food and Drug Administration, United States]

Grants for Research in Glomerular Diseases (R01) (PA-10-113) [National Institute of Diabetes and Digestive and Kidney Diseases, United States]

MHRA Seeks Views On Making Information About Medicines Available Online – Your Last Chance to Input [Medicines and Healthcare Products Regulatory Agency, United Kingdom]

Information Sent to Healthcare Professionals in February 2010 About the Safety of Medicines [Medicines and Healthcare Products Regulatory Agency, United Kingdom]

Prescription Medicines Business Process Reform Project: Improved Access to Information (Updated) [Therapeutic Goods Administration, Australia]


EVENTS

American Association for Cancer Research (AACR) 101st Annual Meeting
April 17-21, 2010
Washington, DC, United States

American Urological Association (AUA) 2010 Annual Meeting
May 29-June 3, 2010
San Francisco, United States

International Society for Stem Cell Research (ISSCR) 8th Annual Meeting
June 16-19, 2010
San Francisco, United States

21st Meeting of the European Association for Cancer Research (EACR) 
June 26-29, 2010
Oslo, Norway

United Kingdom National Stem Cell Network (UKNSCN) Third Annual Scientific Conference
July 12-14, 2010
Nottingham, United Kingdom

2010 World Cancer Congress
August 18-21, 2010
Beijing, China


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